Category: 90226-87-2

Electric Literature of 90226-87-2, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 90226-87-2, Name is (1-Ethylpiperidin-4-yl)methanol, molecular formula is C8H17NO. In a Article，once mentioned of 90226-87-2

A series of benzo[h] [1,6] naphthyridine and azepino[3,2-c] quinoline derivatives were prepared and evaluated to determine the necessary requirements for high affinity on the 5-HT4 receptors and high selectivity versus other receptors. The compounds were synthesized by substituting the chlorine atom of benzonaphthyridines and azepinoquinolines with various N-alkyl-4-piperidinylmethanolates. They were evaluated in binding assays with [3H]GR 113808 as the 5-HT4 receptor radioligand. The affinity values (Ki or inhibition percentages) depended upon the substituent on the aromatic ring on one hand and the substituent on the lateral piperidine chain on the other hand. A chlorine atom produced a marked drop in activity while a N-propyl or N-butyl group gave compounds with nanomolar affinities (1 < Ki < 10 nM). Among the most potent ligands (3a, 4a, 5a), 4a was selected on the basis of its high affinity and selectivity for pharmacological screening and was evaluated in vivo in specific tests. This compound reveals itself as an antagonist/low partial agonist in the COS-7 cells stably expressing the 5-HT4(a) receptor. Derivative 4a also showed in vivo potent analgesic activity in the writhing test at very low doses. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Electric Literature of 90226-87-2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 90226-87-2, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H8226N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of: (1-Ethylpiperidin-4-yl)methanol. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 90226-87-2

Based on the definition of a 5-HT4 receptor antagonist pharmacophore, a series of pyrrolo[1,2-a]thieno[3,2-e] and pyrrolo[1,2-a]thieno[2,3-e] pyrazine derivatives were designed, prepared, and evaluated to determine the properties necessary for high-affinity binding to 5-HT4 receptors. The compounds were synthesized by substituting the chlorine atom of the pyrazine ring with various N-alkyl-4-piperidinylmethanolates. They were evaluated in binding assays with [3H]GR113808 (1) as the 5-HT4 receptor radioligand. The affinity values (Ki or inhibition percentages) were affected by both the substituent on the aromatic ring and the substituent on the lateral piperidine chain. A methyl group on the tricyclic ring produced a marked increase in affinity while an N-propyl or N-butyl group gave compounds with nanomolar affinities. Among the most potent ligands, 34d was selected for further pharmacological studies and evaluated in vivo. This compound acts as an antagonist/weak partial agonist in COS-7 cells stably expressing the 5-HT4(a) receptor and is of great interest as a peripheral antinociceptive agent.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Quality Control of: (1-Ethylpiperidin-4-yl)methanol, you can also check out more blogs about90226-87-2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H8225N – PubChem