Category: 896464-16-7

896464-16-7, tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,896464-16-7

Step 1: To a solution of compound 24a (1 equivalent) in dichloromethane, compound 11a (1.5 eq.) was added sequentially.HOAT (1.5 eq.), HATU (2 eq.), DIPEA (6 eq.), stirred at room temperature for 12 hours.The solvent is then sparged off and directly isolated by column chromatography to afford intermediate 24b.

As the paragraph descriping shows that 896464-16-7 is playing an increasingly important role.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Chinese Academy Of Sciences Shanghai Life Sciences Institute; Zhang Ao; Gao Daming; Ni Jiabin; Hu Hongli; Ding Chunyong; (55 pag.)CN107814792; (2018); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

896464-16-7, tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a microwave vessel, a mixture of tert-butyl 2,7-diazaspiro[3 .5 ]nonane-7-carboxylate (85 mg, 0.38 mmol), DIEA (44 jiL, 0.25 mmol), and 4-(6-fluoropyridin-3-yl)-6-(i-methyl-1H- pyrazol-4-yl)pyrazolo[i,5-a]pyridine-3-carbonitrile (Intermediate P6; 40 mg, 0.13 mmol) in DMSO (1 mL) was subjected to microwave irradiation at 125 C for 2 h. After cooling to ambient temperature, the reaction mixture was directly purified by reverse-phase preparative HPLC (10 to 80% acetonitrile/water) to give the title compound (12 mg, 18% yield). MS (apci) m/z = 525.2 (M+H)., 896464-16-7

896464-16-7 tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate 24820512, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ARRAY BIOPHARMA, INC.; ANDREWS, Steven W.; BLAKE, James F.; CHICARELLI, Mark J.; GOLOS, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; (594 pag.)WO2017/11776; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

896464-16-7,896464-16-7, tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add to tert-butyl 2,7-azaspiro[3,5]nonane-7-carboxylate (226 mg, 1.0 mmol) at room temperature4-trifluoromethoxyacetophenone (204 mg, 1.0 mmol) andTetraisopropyl titanate (568 mg, 2.0 mmol) was reacted at 80 C overnight.After cooling to room temperature, sodium cyanoborohydride (188 mg, 3.0 mmol) was added to the mixture, and the mixture was reacted at 40 C for 2 hours.Work-up: extraction with water and extraction with dichloromethane (20 mL x 3).The organic layer was combined, dried over anhydrous magnesium sulfate and evaporated(Ethyl acetate: petroleum ether = 1 : 2) gave pale yellow oil (150 mg).

The synthetic route of 896464-16-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Bio-technology Institute; Liu Mingliang; Wang Apeng; Lv Kai; Tao Zeyu; Ma Chao; Han Bing; Ma Xican; Wang Aoyu; Xu Shijie; (23 pag.)CN110204546; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem