Category: 88495-54-9

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid, molecular formula is C11H19NO4. In an article, author is Ezzatzadeh, Elham,once mentioned of 88495-54-9, Product Details of 88495-54-9.

A novel one-pot three-component synthesis of benzofuran derivatives via Strecker reaction: Study of antioxidant activity

A three-component Strecker-type reactions was applied for the synthesis of benzofuran derivatives through the reaction of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone (euparin), primary amines and trimethylsilyl cyanide (TMSCN) in the presence of catalytic amount of ZnO-nanorods (ZnO-NR) and piperidine in acetonitrile at room temperature. The method has proved to be synthetically simple, and effective with high atom economy and yield. The catalyst also revealed significant reusability. Moreover, the antioxidant activity and free radical scavenging capacity of the newly synthesized such as 4a, 4c, 6a and 6c was screened using free radical scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays and compared with hydroxytoluene (BHT) and tert-butylhydroquinone (TBHQ). These compounds exhibit good DPPH radical scavenging and ferric reducing antioxidant power (FRAP) assays.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Application of 88495-54-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid, SMILES is O=C([C@@H]1CN(C(OC(C)(C)C)=O)CCC1)O, belongs to piperidines compound. In a article, author is Celik, Ismail, introduce new discover of the category.

Evaluation of Activity of Some 2,5-Disubstituted Benzoxazole Derivatives against Acetylcholinesterase, Butyrylcholinesterase and Tyrosinase: ADME Prediction, DFT and Comparative Molecular Docking Studies

In this study, p-tert-butyl at position 2 and acetamide bridged 4-substituted piperazine/piperidine at position 5 bearing benzoxazole derivatives were evaluated for their in vitro inhibitory activity against AChE, BChE and Tyrosinase, which are important targets in reducing the adverse effects of Alzheimer’s disease. The most active 1 g inhibited the BChE at a concentration of 50 mu M by 54 +/- 0.75%. Molecular docking studies of the compounds against BChE (PDB: 4BDS) were performed with Schrodinger and AutoDock Vina and the results were compared. Schrodinger docking scores were found to be more consistent. Estimated ADME profiles and bioactivity scores of the compounds were calculated and found to be compatible with Lipinski and other limiting rules. Geometric optimization parameters, MEP analysis and HUMO and LUMO quantum parameters of the most active 1 g were calculated by using DFT/B3LYP theory and 6-311 G (d,p) base set and results was viewed.

Application of 88495-54-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 88495-54-9 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Application In Synthesis of (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid, SMILES is O=C([C@@H]1CN(C(OC(C)(C)C)=O)CCC1)O, belongs to piperidines compound. In a article, author is Romero-Ibanez, Julio, introduce new discover of the category.

Concise and Environmentally Friendly Asymmetric Total Synthesis of the Putative Structure of a Biologically Active 3-Hydroxy-2-piperidone Alkaloid

An asymmetric total synthesis of stereoisomers of a putative structure of 3-hydroxy-2-piperidone alkaloid derivative is described. This route is not only concise and efficient but also is achieved under an environmentally friendly approach. To this end, a direct and double C-H oxidation reaction of simple benzylated piperidine and Baker’s yeast reduction of a carbonyl group allowed the rapid access to the optically enriched ( S )-1-benzyl-3-hydroxy-2-piperidone in only three steps. The NMR data agreed with those obtained in the first total synthesis (and in discrepancy with the natural product), however, optical rotation did not match with both neither the natural and synthetic material.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 88495-54-9. Application In Synthesis of (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid, SMILES is O=C([C@@H]1CN(C(OC(C)(C)C)=O)CCC1)O, in an article , author is Ghatpande, Nitin G., once mentioned of 88495-54-9, Application In Synthesis of (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid.

A brief overview on recent advances in spiro[chromane-2,4 ‘-piperidine]-4 (3H)-one-functionalized compounds in medicinal chemistry research

The spiro[chromane-2,4′-piperidine]-4(3H)-one is an important pharmacophore. It is a structural component in many drugs, drug candidates (or lead compounds) and various biochemical reagents. This review demonstrated an impressive progress in syntheses of spiro[chromane-2,4′-piperidine]-4(3H)-one-derived compounds in the recent years and focuses on features of their biological relevance’s. The prospects for the development of new biologically active substances containing a spiro[chromane-2,4’-piperidine]-4(3H)-one pharmacophore are analyzed and briefly discussed in terms of its structure, reaction, mechanism, scope and potential utility.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid, molecular formula is C11H19NO4, belongs to piperidines compound, is a common compound. In a patnet, author is Zhang, Jianbo, once mentioned the new application about 88495-54-9, Safety of (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid.

Catalytic Access to Bridged Sila-N-heterocycles from Piperidines via Cascade sp(3) and sp(2) C-Si Bond Formation

Described herein is the development of an unprecedented route to bridged sila-N-heterocycles via B(C6F5)(3)-catalyzed cascade silylation of N-aryl piperidines with hydrosilanes. Mechanistic studies indicated that an outer-sphere ionic path is operative to involve three sequential catalytic steps having N-silyl piperidinium borohydride as a resting species: (i) dehydrogenation of the piperidine ring, (ii) beta-selective hydrosilylation of a resultant enamine intermediate, and (iii) intramolecular dehydrogenative sp(2) C-H silylation.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 88495-54-9. The above is the message from the blog manager. Safety of (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid. In a document, author is Javid, Jamila, introducing its new discovery. Category: piperidines.

Comparative conventional and microwave assisted synthesis of heterocyclic oxadiazole analogues having enzymatic inhibition potential

A comparative microwave assisted and conventional synthetic strategies were applied to synthesize heterocyclic 1,3,4-oxadiazole analogues as active anti-enzymatic agents. Green synthesis of compound1was achieved by stirring 4-methoxybenzenesulfonyl chloride (a) and ethyl piperidine-4-carboxylate (b). Compound1was converted into respective hydrazide (2) by hydrazine and then into 1,3,4-oxadiazole (3) by CS(2)on reflux. The electrophiles,N-alkyl/aralkyl/aryl-2-bromopropanamides (6a-p) were synthesized and converted toN-alkyl/aralkyl/aryl-2-propanamide derivatives (7a-p) by reaction with3under green chemistry. Microwave assisted method was found to be effective relative to conventional method.C-13-NMR,H-1-NMR and IR techniques were availed to corroborate structures of synthesized compounds and then subjected to screening against lipoxygenase (LOX), alpha-glucosidase, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. A number of compounds presented better potential against these enzymes. The most active compounds against LOX and alpha-glucosidase enzymes were subjected to molecular docking study to explore their interactions with the active sites of the enzymes.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 88495-54-9 help many people in the next few years. Category: piperidines.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid, molecular formula is C11H19NO4. In an article, author is Liu, Huixia,once mentioned of 88495-54-9, Application In Synthesis of (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid.

Crystal structure of 5-methyl-3-phenyl-1-tosyl-1,2,3,4-tetrahydropyridine, C19H21NO2S

C19H21NO2S, orthorhombic, Pbca (no. 61), a =16.792(5) angstrom, b = 9.153(3) angstrom, c = 22.809(6) angstrom, V = 3505.8(16) angstrom(3), Z = 8, R-gt(F) = 0.0622, wR(ref)(F-2) = 0.1494, T = 296(2) K.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid, molecular formula is , belongs to piperidines compound. In a document, author is Gurevich, K. G., Recommanded Product: (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid.

Synthesis and Anti-Aggregation Activity of 2-[3-Methyl-1-Ethylxanth-8-Ylthio]Acetate Salts Containing Thietanyl and Dioxothietanyl Rings

Reactions of 2-[1-ethyl-3-methyl-7-(thietan-3-yl)- and 2-[1-ethyl-3-methyl-7-(1,1-dioxothietan-3-yl)xanth- 8-ylthio]acetic acids with amines (diethylamine, monoethanolamine, diethanolamine, triethanolamine, piperidine, cyclohexylamine, and benzylamine) gave 42 – 89% yields of 2-[1-ethyl-3-methyl-xanth-8-ylthio]- acetate salts containing thietanyl and dioxothietanyl rings. The structures of the synthesized compounds were confirmed using IR and PMR spectroscopy. The synthesized compounds exhibited anti-aggregation activity.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid, SMILES is O=C([C@@H]1CN(C(OC(C)(C)C)=O)CCC1)O, in an article , author is Sumesh, Remani Vasudev, once mentioned of 88495-54-9, Computed Properties of C11H19NO4.

Pyrano[2,3-f]pyrazolo[3,4-b]quinoline-3-carbonitriles: A three-component synthesis and AChE inhibitory studies

The one-pot three-component reaction of 3-methyl-1-phenyl-1,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one, aromatic aldehydes, and malononitrile in the presence of piperidine in ethanol has been carried out. The reaction proceeded through domino Knoevenagel condensation – Michael addition – O-cyclization sequence of reactions in a single transformation affording structurally intriguing novel pyrano[2,3-f]pyrazolo[3,4-b]quinoline-3-carbonitriles in excellent yields in short reaction time. The high-throughput AChE inhibition studies of these pyrano[2,3-f]pyrazolo[3,4-b]quinoline-3-carbonitriles disclosed one compound with maximum potency with an IC50 value of 2.6 mu M/L. The structure-activity relationship revealed that the pyrano[2,3-f]pyrazolo[3,4-b]quinoline-3-carbonitriles bearing alkyl or alkoxy substituted phenyl ring at C-4 exhibited more potency than the compounds with halogen-substituted phenyl ring.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 88495-54-9, you can contact me at any time and look forward to more communication. Computed Properties of C11H19NO4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid, SMILES is O=C([C@@H]1CN(C(OC(C)(C)C)=O)CCC1)O, in an article , author is Teno, Naoki, once mentioned of 88495-54-9, Recommanded Product: 88495-54-9.

Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists

Famesoid X receptor (FXR) plays a major role in the control of cholesterol metabolism. Antagonizing transcriptional activity of FXR is an effective means to treat the relevant metabolic syndrome. Some of antagonists so far have the charged functions; however, they may negatively affect the pharmacokinetics. We describe herein a structure activity relationship (SAR) exploration of nonacidic FXR antagonist 6 focusing on two regions in the structure and biological evaluation of nonacidic 10 with the characteristic N-acylated piperidine group obtained from SAR studies. As the robust affinity to FXR is feasible with our nonacidic analogue, 10 is among the most promising candidates for in vivo testing.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem