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The present invention provides novel substituted alkenyl compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

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Piperidine – Wikipedia,
Piperidine | C5H23853N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, name: 1-Boc-4-(4-Iodo-1H-pyrazol-1-yl)piperidine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 877399-73-0, Name is 1-Boc-4-(4-Iodo-1H-pyrazol-1-yl)piperidine, molecular formula is C13H20IN3O2. In a Patent, authors is ，once mentioned of 877399-73-0

The present invention relates to the use of (R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, a novel c-Met/HGFR inhibitor, for treating abnormal cell growth in mammals. In particular, the invention provides methods of treating mammals suffering from cancer.

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Recommanded Product: 877399-73-0, Which mentioned a new discovery about 877399-73-0

The invention provides a novel substituted alkynyl compound and its pharmaceutically acceptable salt and medicinal preparation, and a use of the novel substituted alkynyl compound and its pharmaceutically acceptable salt and medicinal preparation in adjustment of protein kinase activity and intercellular or intracellular signal response. The invention also relates to a pharmaceutical composition containing the novel substituted alkynyl compound and a method for treating high-proliferative diseases of mammals especially such as human by the pharmaceutical composition.

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The present invention provides compounds of Formula (II) for the treatment of cancer, rheumatoid arthritis and other diseases.

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Piperidine – Wikipedia,
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Synthetic Route of 877399-73-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 877399-73-0, Name is 1-Boc-4-(4-Iodo-1H-pyrazol-1-yl)piperidine, molecular formula is C13H20IN3O2. In a Patent，once mentioned of 877399-73-0

The present invention provides novel substituted alkynyl compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 877399-73-0, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 877399-73-0, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H23852N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. SDS of cas: 877399-73-0. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 877399-73-0

The present disclosure provides hetero-bicyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, hydrates, N-oxides, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by Bruton’s tyrosine kinase (Btk) activity, The disclosure also relates to the process of preparation of compounds of Formula (I). These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Bruton’s tyrosine kinase (Btk), such as inflammatory and/or autoimmune disorder, cell proliferation, rheumatoid arthritis, psoriasis, psoriatic arthritis, transplant rejection, graft-versus-host disease, multiple sclerosis, inflammatory bowel disease, allergic diseases, asthma, type 1 diabetes, myasthenia gravis, hematopoetic disfunction, B-cell malignancies, systemic lupus, erythematosus or other disorders.

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Reference：
Piperidine – Wikipedia,
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Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 877399-73-0. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 877399-73-0

A series of 3-amino-benzo[d]isoxazole-/3-aminoindazole-based compounds were designed, synthesized and pharmacologically evaluated as tyrosine kinase c-Met inhibitors. The SAR study was conducted leading to identification of nine compounds (8d, 8e, 12, 28a-d, 28h and 28i) with IC50s less than 10 nM against c-Met. Compound 28a stood out as the most potent c-Met inhibitor displaying potent inhibitory effects both at enzymatic (IC50 = 1.8 nM) and cellular (IC50 = 0.18 muM on EBC-1 cells) levels. In addition, 28a had a relatively good selectivity compared to a panel of our in-house 14 RTKs.

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Reference of 877399-73-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.877399-73-0, Name is 1-Boc-4-(4-Iodo-1H-pyrazol-1-yl)piperidine, molecular formula is C13H20IN3O2. In a Patent，once mentioned of 877399-73-0

The present invention provides a having the general formula (I) indicated by the structure of the 3 – amino – benzene and five-membered heterocyclic compound, its pharmaceutically acceptable salt or a pharmaceutically acceptable solvate, preparation method thereof, and in preparation for inhibiting tyrosine kinase c – Met activity of the drug in use; in preparation for preventing or treating with in vivo of hepatocyte growth factor receptor (c – Met) related abnormal cell proliferation, the shape change and movement function of diseases associated with and hyperfunction angiogenesis metastasis-related diseases in the use of the drug, especially in preparation for the treatment or prevention of tumor growth and transfer of the use in the medicament. The invention realizes the target compound to c – Met with VEGFR 2 activity of separation, and they retain good c – Met inhibitory activity. (by machine translation)

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H23855N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， name: 1-Boc-4-(4-Iodo-1H-pyrazol-1-yl)piperidine, Which mentioned a new discovery about 877399-73-0

The process is simple raw materials are cheap and 4 – (4 – easily available, and) the reaction selectivity is high to, obtain-halo – 111H 4 -pyraz- 1 1-yl, piperidine – 1 1-yl piperi- 1 1 4 – (tert Mitsunobu- butyl-pH tert 4 – (4 -butyl carboxylate) in a yield of up to. The) yield of tert, butyl peroxycarboxylic acid Boc 4 – (4 – tert-butyl ester is as) high as. above, more and less than or equal, to, about sup. 98.5% .) 4 – (4 . (by machine translation)

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 877399-73-0, molcular formula is C13H20IN3O2, introducing its new discovery. HPLC of Formula: C13H20IN3O2

The invention belongs to the field of chemical medicines, and relates to a [1,2,4]triazine[6,1-a]isoindole compound with ALK/C-MET kinase duplex restraining activity, a pharmaceutical composition containing the compound and application of the compound or the composition in medicine preparation, in particular to hydrochloride and application of the [1,2,4]triazine[6,1-a]isoindole compound. The compound has good dissolubility and stability, and a better option is provided for dosage form research.

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Piperidine – Wikipedia,
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