Category: 87120-72-7

Tikhomirov, Alexander S.’s team published research in European Journal of Medicinal Chemistry in 2020 | CAS: 87120-72-7

tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Quality Control of tert-Butyl 4-aminopiperidine-1-carboxylate

《Amides of pyrrole- and thiophene-fused anthraquinone derivatives: a role of the heterocyclic core in antitumor properties》 was written by Tikhomirov, Alexander S.; Litvinova, Valeria A.; Andreeva, Daria V.; Tsvetkov, Vladimir B.; Dezhenkova, Lyubov G.; Volodina, Yulia L.; Kaluzhny, Dmitry N.; Treshalin, Ivan D.; Schols, Dominique; Ramonova, Alla A.; Moisenovich, Mikhail M.; Shtil, Alexander A.; Shchekotikhin, Andrey E.. Quality Control of tert-Butyl 4-aminopiperidine-1-carboxylate And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

A new series of naphtho[2,3-f]indole-3-carboxamides I [R1 = Me; R2 = (3S)-3-aminopyrrolidin-1-yl, ((3S)-pyrrolidin-3-yl)amino, 4-amino-1-piperidyl, etc.; X = NH, NMe, NBn, etc.;] and anthra[2,3-b]thiophene-3-carboxamides I [R1 = H, X = S] was synthesized via coupling the resp. acids with cyclic diamines and dissected the role of the heterocyclic core in antitumor properties. New compounds demonstrated a submicromolar antiproliferative potency close to doxorubicin (Dox) against five tumor cell lines of various tissue origin. In contrast to Dox, the new compounds were similarly cytotoxic for HCT116 colon carcinoma cells (wild type p53) and their isogenic p53 knockout counterparts. Compound I [R1 = Me; R2 = (3S)-3-aminopyrrolidin-1-yl; X = NH] formed more affine complexes with DNA duplex than furan and thiophene analogs, a property that could be translated into a stronger inhibition of topoisomerase 1 mediated DNA unwinding. At tolerable doses the water soluble derivative I [R1 = Me; R2 = (3S)-3-aminopyrrolidin-1-yl; X = NH] significantly inhibited tumor growth (up to 79%) and increased the lifespan (153%) of mice bearing P388 lymphoma transplants. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7Quality Control of tert-Butyl 4-aminopiperidine-1-carboxylate)

tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Quality Control of tert-Butyl 4-aminopiperidine-1-carboxylate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Wang, Xuefeng’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2019 | CAS: 87120-72-7

tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Reference of tert-Butyl 4-aminopiperidine-1-carboxylate

The author of 《Photoredox-catalyzed synthesis of sulfones through deaminative insertion of sulfur dioxide》 were Wang, Xuefeng; Kuang, Yunyan; Ye, Shengqing; Wu, Jie. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Reference of tert-Butyl 4-aminopiperidine-1-carboxylate The author mentioned the following in the article:

Katritzky salts were used as the alkyl radical precursors with the insertion of sulfur dioxide under photoredox catalysis. This transformation first enables direct generation of various alkylsulfonyl radicals by photoinduced single electron reduction, leading to diverse dialkyl sulfones in good to excellent yields. A radical pathway was proposed under visible-light induced conditions with the insertion of sulfur dioxide. In the experiment, the researchers used tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7Reference of tert-Butyl 4-aminopiperidine-1-carboxylate)

tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Reference of tert-Butyl 4-aminopiperidine-1-carboxylate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Analyzing the synthesis route of 87120-72-7

The synthetic route of 87120-72-7 has been constantly updated, and we look forward to future research findings.

87120-72-7, tert-Butyl 4-aminopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

87120-72-7, Method G:Example G-1 : [1 -(4-Acryloylamino-benzenesulfonyl)-piperidin-4-yl]-carbamic acid benzyl ester4-Benzyloxycarbonylamino-piperidine-1 -carboxylic acid tert-butyl ester[00456] Diisopropylethylamine (0.9ml, 5.5mmol) was added in one portion to a stirred solution of 4-amino-piperidine-1 -carboxylic acid tert-butyl ester (1 .0g, 5.0mmol) in THF (10ml) at room temperature. To this mixture was added benzyl chloroformate (0.78ml, 5.5mmol) drop wise and the mixture was stirred at room temperature under a nitrogen atmosphere for 18 hours. After this time the mixture was diluted with ethyl acetate (50ml) and washed with water (100ml), saturated NaHCO3 (100ml) and HCl (100ml, 2M). The organic layer was separated, dried (MgSO ), filtered and concentrated under vacuum. The resulting residue was purified by flash column chromatography (elution: 50% heptane, 50% ethyl acetate) to give the title compound (1 .2g, 73% yield) as a colourless oil. Tr = 2.08 min m/z (ES+) (M+ Na+) 357.

The synthetic route of 87120-72-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHDI, INC.; DOMINGUEZ, Celia; WITYAK, John; PRIME, Michael; COURTNEY, Stephen; YARNOLD, Christoper; BROOKFIELD, Frederick; MARSTON, Richard; MACDONALD, Douglas; WO2011/60321; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem