Category: 851847-62-6

Liu, Gang; Campbell, Brian T.; Holladay, Mark W.; Ford Pulido, Julia M.; Hua, Helen; Gitnick, Dana; Gardner, Michael F.; James, Joyce; Breider, Mike A.; Brigham, Daniel; Belli, Barbara; Armstrong, Robert C.; Treiber, Daniel K. published their research in ACS Medicinal Chemistry Letters on December 13 ,2012. The article was titled 《Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases》.Quality Control of 1-Cyclopropylpiperidin-4-ol The article contains the following contents:

A series of potent, selective platelet-derived growth factor receptor-family kinase inhibitors was optimized starting from a globally selective lead mol. 4 through structural modifications aimed at improving the physiochem. and pharmacokinetic properties, as exemplified by 18b. Further clearance reduction via per-methylation of the α-carbons of a solubilizing piperidine nitrogen resulted in advanced leads 22a and 22b. Results from a mouse tumor xenograft, a collagen-induced arthritis model, and a 7 day rat in vivo tolerability study culminated in the selection of compound 22b (AC710) as a preclin. development candidate. In the experiment, the researchers used 1-Cyclopropylpiperidin-4-ol(cas: 851847-62-6Quality Control of 1-Cyclopropylpiperidin-4-ol)

1-Cyclopropylpiperidin-4-ol(cas: 851847-62-6) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Quality Control of 1-Cyclopropylpiperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Pierson, Pascale David; Fettes, Alec; Freichel, Christian; Gatti-McArthur, Silvia; Hertel, Cornelia; Huwyler, Jorg; Mohr, Peter; Nakagawa, Toshito; Nettekoven, Matthias; Plancher, Jean-Marc; Raab, Susanne; Richter, Hans; Roche, Olivier; Rodriguez Sarmiento, Rosa Maria; Schmitt, Monique; Schuler, Franz; Takahashi, Tadakatsu; Taylor, Sven; Ullmer, Christoph; Wiegand, Ruby published an article in Journal of Medicinal Chemistry. The title of the article was 《5-Hydroxyindole-2-carboxylic Acid Amides: Novel Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity》.HPLC of Formula: 851847-62-6 The author mentioned the following in the article:

Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer. Several pieces of evidence across different species, including primates, underscore the implication of the histamine 3 receptor (H3R) in the regulation of food intake and body weight and the potential therapeutic effect of H3R inverse agonists. A pharmacophore model, based on public information and validated by previous investigations, was used to design several potential scaffolds. Out of these scaffolds, the 5-hydroxyindole-2-carboxylic acid amide appeared to be of great potential as a novel series of H3R inverse agonist. Extensive structure-activity relationships revealed the interconnectivity of microsomal clearance and hERG (human ether-a-go-go-related gene) affinity with lipophilicity, artificial membrane permeation, and basicity. This effort led to the identification of compounds reversing the (R)-α-methylhistamine-induced water intake increase in Wistar rats and, further, reducing food intake in diet-induced obese Sprague-Dawley rats. Of these, the biochem., pharmacokinetic, and pharmacodynamic characteristics of (4,4-difluoropiperidin-1-yl)[1-isopropyl-5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl]methanone 36 are detailed. In addition to this study using 1-Cyclopropylpiperidin-4-ol, there are many other studies that have used 1-Cyclopropylpiperidin-4-ol(cas: 851847-62-6HPLC of Formula: 851847-62-6) was used in this study.

1-Cyclopropylpiperidin-4-ol(cas: 851847-62-6) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. HPLC of Formula: 851847-62-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem