Category: 84762-70-9

On June 30, 1990, Nemeryuk, M. P.; Sedov, A. L.; Ryabokon, N. A.; Ershova, Yu. A.; Sokolova, A. S.; Losev, A. G.; Chernov, V. A.; Safonova, T. S. published an article.Application In Synthesis of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine The title of the article was 4(5)-Substituted 1,2,3-triazole-5(4)-carboxylic acid derivatives: synthesis and antitumor activity. And the article contained the following:

The title compounds [I, X = e.g., CO2Me, C(:NH)SMe, piperidino- or morpholino(imino)methyl, and Y = SMe, Cl, CN, OMe, SCH2Ph, 1-methyl-1-isobutyl-4-nitroimidazolyl-5-thio) were prepared by the diazotization of aminopyrimidines. The structure of the products was dependent on the type of substituents present and the conditions of carrying out the reaction. The compounds had antitumor activity both in vitro and in vivo. The highest activity was shown by I (X = CO2Me, Y = 2-nitro-5-acetyl-3-thienylthio) or X = C(:NH)NMe2 and Y = OMe). I had low toxicity. The experimental process involved the reaction of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine(cas: 84762-70-9).Application In Synthesis of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine

The Article related to triazolecarboxylate derivative preparation antitumor, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Application In Synthesis of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On June 30, 1990, Nemeryuk, M. P.; Sedov, A. L.; Ryabokon, N. A.; Ershova, Yu. A.; Sokolova, A. S.; Losev, A. G.; Chernov, V. A.; Safonova, T. S. published an article.Application In Synthesis of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine The title of the article was 4(5)-Substituted 1,2,3-triazole-5(4)-carboxylic acid derivatives: synthesis and antitumor activity. And the article contained the following:

The title compounds [I, X = e.g., CO2Me, C(:NH)SMe, piperidino- or morpholino(imino)methyl, and Y = SMe, Cl, CN, OMe, SCH2Ph, 1-methyl-1-isobutyl-4-nitroimidazolyl-5-thio) were prepared by the diazotization of aminopyrimidines. The structure of the products was dependent on the type of substituents present and the conditions of carrying out the reaction. The compounds had antitumor activity both in vitro and in vivo. The highest activity was shown by I (X = CO2Me, Y = 2-nitro-5-acetyl-3-thienylthio) or X = C(:NH)NMe2 and Y = OMe). I had low toxicity. The experimental process involved the reaction of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine(cas: 84762-70-9).Application In Synthesis of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine

The Article related to triazolecarboxylate derivative preparation antitumor, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Application In Synthesis of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On January 31, 1985, Levkovskaya, L. G.; Sazonov, N. V.; Grineva, N. A.; Mamaeva, I. E.; Serochkina, L. A.; Safonova, T. S. published an article.COA of Formula: C9H13ClN4 The title of the article was Study of nitrogen- and oxygen-containing heterocycles. 42. Pyrimido[4,5-b]- and pyrido[2,3-b]-1,4-benzoxazepines. And the article contained the following:

Oxazepines I (R = H, Cl, R1X = N, CH, ClCH, R2 = NHCH2Ph, NHPh, piperidino, morpholino, NH2, Cl, OH, 1-methylpiperazinyl, H) were prepared in 25-95% yields by cyclocondensation of pyridines or pyrimidines II wiwth 5,2-R3YC6H3CHO in DMF containing NaH. Reduction of I by NaBH4 in absolute EtOH gave 76-100% of the corresponding 5,6-dihydro derivatives The experimental process involved the reaction of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine(cas: 84762-70-9).COA of Formula: C9H13ClN4

The Article related to benzopyridooxazepine, benzopyrimidooxazepine, pyridooxazepine benzo, pyrimidooxazepine, oxazepine pyrido pyrimido, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.COA of Formula: C9H13ClN4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On October 7, 1982, Sazonov, N. V.; Grineva, N. A.; Safonova, T. S. published a patent.Safety of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine The title of the patent was Pyrimido[4,5-b][1,4]benzoxazepine derivatives. And the patent contained the following:

I (R = Cl, OH, NH2, benzyl- or phenyl-substituted amino, N-methylpiperazino, R1 = H; R = butyl- or benzyl-substituted amino, morpholino, piperidino, R1 = Br; R = morpholino, R1 = NO2) were prepared by treating aminochloropyrimidines II with hydroxybenzaldehydes III (or alk. salts) in DMF or toluene at 100-20°. The experimental process involved the reaction of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine(cas: 84762-70-9).Safety of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine

The Article related to pyrimidobenzoxazepine amino, benzoxazepine pyrimido, oxazepine pyrimidobenz, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Safety of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On January 31, 1986, Nemeryuk, Michal P.; Sedov, Andrej L.; Safonova, Tamara S.; Cerny, Antonin; Krepelka, Jiri published an article.Category: piperidines The title of the article was Transformations of substituted 5-aminopyrimidines under conditions of diazotization. And the article contained the following:

Diazotization of aminopyrimidines I (R = H; R1 = SMe, SCH2Ph, OMe, H, OH; R2 = OMe, Cl, OH, etc.) gave triazoles II (R3 = CO2Me, COSMe, COSCH2Ph, CONH2, etc.). Under similar conditions diaminopyrimidines I [R = NH2, R1 = SCH2C6H4R4-4 (R4 = NO2, CO2Et, CONHCHMe2, H), R2 = Me] gave pyrimidotriazine N-oxides III. The experimental process involved the reaction of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine(cas: 84762-70-9).Category: piperidines

The Article related to aminopyrimidine diazotization, triazole, pyrimidotriazine oxide alkylthio, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On July 31, 1995, Nemeryuk, M. P.; Sedov, A. L.; Safonova, T. S.; Shvarts, G. Ya.; Faiermark, I. F.; Mashkovskii, M. D. published an article.COA of Formula: C9H13ClN4 The title of the article was Synthesis and pharmacological properties of 4(5)-substituted 5(4)-amidino-1,2,3-triazoles. And the article contained the following:

Title compounds I [R1 = R2 = Me; R1R2 = (CH2)5, (CH2)2O(CH2)2; R3 = Cl, MeO, PhCH2S, 3,4-Cl2C6H3CH2S] were prepared by diazotization of 4-(dialkylamino)-5-aminopyrimidines II in aqueous HCl. Triazole I [R1R2 = (CH2)2O(CH2)2; R3 = Cl] showed antihypertensive effect in rats at dose 10 mg/kg. It also showed low toxicity with LD50 > 1000 mg/kg. The experimental process involved the reaction of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine(cas: 84762-70-9).COA of Formula: C9H13ClN4

The Article related to amidinotriazole antihypertensive preparation, diazotization dialkylamino aminopyrimidine, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.COA of Formula: C9H13ClN4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem