Category: 845909-49-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.845909-49-1,Ethyl 4-fluoropiperidine-4-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.,845909-49-1

Intermediate B2(IIQ: 4-Fluoro-1 -(tetrahydro-pyran-4-yl)-piperidine-4-carboxylic acid ethyl esterTo a 250 mL RB were added compound B2(l) ethyl 4-fluoropiperidine-4- carboxylate, hydrochloride (1.25 g, 5.91 mmol, 1.0 eq), CH2CI2 (20 mL), 4- oxotetrahydropyranone B2(ll) (0.61 mL, 6.50 mmol, 1.10 eq), and glacial HOAc (0.340 mL, 5.91 mmol, 1.0 eq). After being stirred at rt for 5 to 10 min, sodium triacetoxyborohydride (2.02 g, 9.45 mmol, 1.60 eq) was added in one portion. A cloudy solution was obtained. After being stirred at rt for 12 h, the reaction mixture was diluted with 150 mL Et2O and 200 mL NaOH (1 M aqueous). The resulting suspension was stirred at rt for 1 h. The organic layer was collected, washed with 200 mL brine, dried over Na2SO4, filtered, and concentrated to afford 320 mg of the desired product, 4- fluoro-1-(tetrahydro-pyran-4-yl)-piperidine-4-carboxylic acid ethyl ester B2(IIO in 21 % yield as a colorless oil. 1H NNR (400 MHz, CDCI3, ppm) delta 1.30 (t, J = 7.08, 3H), 1.56- 1.66 (m, 2H), 1.74-1.78 (m, 2H), 1.94-2.21 (m, 4H), 2.46-2.55 (m, 3H), 2.82-2.85 (m, 2H), 3.38 (ddd, J = 1.52, 11.84, 11.84, 2H), 4.03 (dd, J = 4.28, 11.08, 2H), 4.24 (q, J = 7.05 Hz, 2H); 19F NMR (376 Hz, CDCI3, ppm) delta -166.94.

845909-49-1 Ethyl 4-fluoropiperidine-4-carboxylate hydrochloride 24729616, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER INC.; WO2008/125945; (2008); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

845909-49-1, Ethyl 4-fluoropiperidine-4-carboxylate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

845909-49-1, Intermediate BKIII): 1-Cyclobutyl-4-fluoro-piperidine-4-carboxylic acid ethyl esterTo a 250 mL round bottle was added compound B1 (P ethyl 4-fluoropiperidine-4- carboxylate, hydrochloride (1.25 g, 5.91 mmol, 1.0 eq), CH2CI2 (40 mL), cyclobutanone B1 (II) (1.30 g, 7.68 mmol, 1.30 eq), and glacial HOAc (0.338 mL, 5.91 mmol, 1.0 eq). After stirring at rt for 5 to 10 min, sodium triacetoxyborohydride (2.00 g, 9.45 mmol, 1.60 eq) was added in one portion. A cloudy solution was obtained. The reaction mixture was stirred at rt for 2 h. To the reaction mixture, 100 mL aqueous NaOH (1 M) was added, and the resulting suspension was stirred at rt for 10 min. The reaction was extracted with EtOAc (150 mL). The organic layer was collected, washed with brine (200 mL), dried over Na2SO4, filtered, and concentrated to afford the desired product, BKIII), as a colorless oil. The crude product was cleaned and subjected to the next step without purification (see next step for the overall reaction yield). 1H NNR (400 MHz, CDCI3, ppm) delta 1.28 (t, J = 7.20 Hz, 3H), 1.64-1.73 (m, 2H), 1.82-1.99 (m, 4H), 2.01-2.21 (m, 6H), 2.72-2.80 (m, 3H), 4.22 (q, J = 7.2 Hz, 2H); 19F NMR (376 Hz, CDCI3, ppm) delta – 166.83.

The synthetic route of 845909-49-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER INC.; WO2008/125945; (2008); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem