845267-78-9, tert-Butyl 2,4-dioxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of 2,4-dioxo-piperidine-l-carboxylic acid tert-butyl ester (40 g, 187.58 mmol) in carbon tetrachloride (500 mL) was added N-bromosuccinimide (33.38 g, 187.58 mmol) portionwise keeping the reaction temperature in the range of 10C-15C. The mixture was further stirred at 10C-15C for 2 hours. The reaction mixture was allowed to warm to room temperature and the solvents evaporated in vacuo. The residue thus obtained was dissolved in AcOEt and washed with H20. The organic layer was separated, dried (Na2S04), filtered and the solvent evaporated in vacuo to yield 30 g (55%) of racemic intermediate 2 that was used in the next step without further purification.
845267-78-9 tert-Butyl 2,4-dioxopiperidine-1-carboxylate 23730999, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; MACDONALD, Gregor, James; TRESADERN, Gary, John; TRABANCO-SUAREZ, Andres, Avelino; PASTOR-FERNANDEZ, Joaquin; WO2011/73347; (2011); A1;,
Piperidine – Wikipedia
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