828243-30-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.828243-30-7,3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid,as a common compound, the synthetic route is as follows.
4-(3-METHYLCARBAMOYLPHERLYL) PIPERIDINE-1-METHYLCARBOXAMIDE : TO a solution of 4-(3-carboxyphenyl)piperidine-1-carboxylic acid tert-butyl ester (1.0 g, 3.27 mmol) in 4 mL of DMF, was added CDI (0.63 g, 3.92 mmol) and the reaction mixture warmed to 60C for two hours. After that time, the mixture was cooled to 0-5C and, a 2 M solution of methylamine in THF (4.91 mL, 9.82 mmol) was added via syringe and the mixture allowed to warm to RT overnight. The mixture was poured into a saturated solution of ammonium chloride, and the product was extracted with ethyl ether (3×50 mL). Organics were washed with water (3X30 mL) and brine (1X15 mL), then dried with magnesium sulfate and concentrated. The dense liquid, crude product, was used into the next step without further treatment. Yield 1.05 g (100%). H NMR (CDCl3, 7.26) 8 1. 48 (s, 9 H), 1.63 (m, 2 H), 1.75 (m, 2 H), 2.69 (m, 1 H), 2.80 (m, 2 H), 3.01 (d, 3 H), 4.23 (br s, 2H), 6.15 (br s, D20,1H), 7.32 (dt, 1H, J = 6. 87, 1.71), 7.34 (t, 1H, J = 6.72), 7.55 (dt, 1H, J = 6.87, 1.71), 7.64 (t, 1H, J= 1.71) ; MS (ES+) m/z 319 (M + H), 341.2 (M + Na).
As the paragraph descriping shows that 828243-30-7 is playing an increasingly important role.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/5395; (2005); A2;,
Piperidine – Wikipedia
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