Category: 826-36-8

Sun, Qianqian published the artcileH₂O₂/O₂ self-supplementing and GSH-depleting Ca²⁺ nanogenerator with hyperthermia-triggered, TME-responsive capacities for combination cancer therapy, Name: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2021), 131485, database is CAplus.

The tumor microenvironment (TME) is complex in composition and unique in nature, and is closely related to the growth, invasion and metastasis of tumor cells. Improving and remodeling the TME to return it to a normalized state can fundamentally disrupt the environment and/or nutrient supply on which tumor cells depend. To achieve this goal, based on the unique physicochem. properties and biol. effects of CaO₂, we designed and constructed a Ca²⁺ nanogenerator (named as CaO₂-Cu/ICG@PCM) that enables H₂O₂/O₂ self-supplementation and GSH depletion. The 808 nm laser induces the heat generation of photosensitizer indocyanine green (ICG) to initiate a series of reactions, followed by the production of copper ions, H₂O₂, O₂ and large amounts of Ca²⁺, which can eventually lead to the combined treatment of photodynamic therapy (PDT), chemodynamic therapy (CDT) and calcium overload. Addnl., the reaction process is accompanied by the generation of Ca(OH)₂, which greatly improves the acidic environment of TME and effectively promotes the oxidation process of GSH by H₂O₂, achieving the purpose of remodeling TME. It is worth mentioning that a large amount of free Ca²⁺ accumulating in tumor cells can rapidly initiate the process of calcium overload and calcification, which can not only play a role in tumor suppression, but also assist CT imaging to detect the effect of treatment. Thus, CaO₂-Cu/ICG@PCM could be a promising candidate for bioimaging and tumor therapy.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C8H6F3NO, Name: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Pei, Dan-Ni published the artcileIn situ organic Fenton-like catalysis triggered by anodic polymeric intermediates for electrochemical water purification, COA of Formula: C9H17NO, the publication is Proceedings of the National Academy of Sciences of the United States of America (2020), 117(49), 30966-30972, database is CAplus and MEDLINE.

Organic Fenton-like catalysis was recently developed for water purification, but redox-active compounds have to be ex situ added as oxidant activators, causing secondary pollution problem. Electrochem. oxidation is widely used for pollutant degradation, but suffers from severe electrode fouling caused by high-resistance polymeric intermediates. Herein, the authors develop an in situ organic Fenton-like catalysis by using the redox-active polymeric intermediates, e.g., benzoquinone, hydroquinone, and quinhydrone, generated in electrochem. pollutant oxidation as H2O2 activators. By taking phenol as a target pollutant, the in situ organic Fenton-like catalysis not only improves pollutant degradation, but also refreshes working electrode with a better catalytic stability. Both 1O2 nonradical and A·OH radical are generated in the anodic phenol conversion in the in situ organic Fenton-like catalysis. The authors’ findings might provide a new opportunity to develop a simple, efficient, and cost-effective strategy for electrochem. water purification

Proceedings of the National Academy of Sciences of the United States of America published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, COA of Formula: C9H17NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Sun, Ping published the artcileStrategic combination of N-doped graphene and g-C₃N₄: Efficient catalytic peroxymonosulfate-based oxidation of organic pollutants by non-radical-dominated processes, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Applied Catalysis, B: Environmental (2020), 119005, database is CAplus.

two metal-free materials, N-doped graphene (rGO-N) and g-C₃N₄, were strategically combined to prepare a novel g-C₃N₄/rGO-N composite to activate peroxymonosulfate (PMS). this g-C₃N₄/rGO-N composite had a large sp. surface area and high graphite-rich N content; thus, exhibited excellent catalytic performance due to the synergistic effect of g-C₃N₄ and rGO-N. the oxidative system effectively degraded various pollutants (acid orange 7, orange G, ciprofloxacin, bisphenol A). radical quenching experiments and ESR spectra anal. showed the novel carbonaceous composite could provide PMS-based, non-radical oxidative pollutant degradation unlike previously reported catalysts for observed degradation via a radical-dominated pathway. real-time wastewater treatment experiments demonstrated the oxidative system potential for environmental remediation applications. the combination strategy provided an innovative approach to fabricate binary metal-free carbonaceous catalysts to perform PMS-based, non-radical oxidative pollutant degradation

Applied Catalysis, B: Environmental published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C47H82N4O15, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Park, Seonghun published the artcileUnprecedented porosity transformation of hierarchically porous TiO₂ derived from Ti-Oxo clusters, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Microporous and Mesoporous Materials (2020), 110153, database is CAplus.

Although attaining a high porosity in TiO₂ is critical to enhancing its photocatalytic and photoelec. activities, its synthesis has been challenging owing to the high reactivity of conventional Ti precursors and the laborious template removal process. Thus, we herein report a versatile method for preparing hierarchically porous organic-functionalized TiO₂ (HiPOTs) using Ti-oxo clusters consisting of a rigid reactive ligand, para-aminobenzoate (p-ABA). The presence of p-ABA as a structure-directing template is crucial to obtain microporous structures with sufficiently high yields. The HiPOTs gradually transform from hierarchically micro/mesoporous structures into mesoporous structures during a sol-gel process. The Brunauer-Emmett-Teller surface areas of the HiPOTs range from 242 to 739 m²/g, which are among the highest reported for porous TiO₂ materials. The presence of p-ABA on the HiPOT surface decreases the band gap of TiO₂ to 2.7 eV, and prolonging the sol-gel process releases greater quantities of p-ABA, thereby increasing the band gap and the crystallinity of the anatase phase. Interestingly, unlike conventional TiO₂, which experiences rapid charge recombination, the Ti³⁺ oxidation states of HiPOTs are successfully isolated during UV irradiation and can be applied as a proof of concept to generate reactive oxygen species such as ¹O₂ and ^{â€?/sup>O–₂.}

Microporous and Mesoporous Materials published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Sun, Xiaoqing published the artcileLong-Lasting and Intense Chemiluminescence of Luminol Triggered by Oxidized g-C₃N₄ Nanosheets, Name: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Analytical Chemistry (Washington, DC, United States) (2020), 92(17), 11860-11868, database is CAplus and MEDLINE.

Most of the known chemiluminescence (CL) systems are flash-type, whereas a CL system with long-lasting and strong emission is very favorable for accurate CL quant. anal. and imaging assays. In this work, we found that the oxidized g-C₃N₄ (g-CN_OX) could trigger luminol-H₂O₂ to produce a long-lasting and intense CL emission. The CL emission lasted for over 10 min and could be observed by the naked eye in a dark room. By means of a CL spectrum, X-ray photoelectron spectra, and ESR spectra, the possible mechanism of this CL reaction was proposed. This strong and long-duration CL emission was attributed to the high catalytic activity of g-CN_OX nanosheets and continuous generation of reactive oxygen species from H₂O₂ on g-CN_OX surface. Taking full advantage of the long-lasting CL property of this system, we proposed one “non-in-situ mixing” mode of CL measurement. Compared with the traditional “in-situ mixing” CL measurement mode, this measurement mode was convenient to operate and had good reproducibility. This work not only provides a long-lasting CL reaction but also deepens the understanding of the structure and properties of g-C₃N₄ material.

Analytical Chemistry (Washington, DC, United States) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H11NO4, Name: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Li, Zhuoqian published the artcileActivation of peroxymonosulfate by iron-biochar composites: Comparison of nanoscale Fe with single-atom Fe, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Journal of Colloid and Interface Science (2021), 582(Part_B), 598-609, database is CAplus and MEDLINE.

A convenient and efficient method to fabricate isolated Fe single-atom catalysts deposited on Myriophyllum aquaticum-based biochar (ISA-Fe/MC) is reported for peroxymonosulfate-based organics degradation Firstly, the Fe nanoparticles anchored on the hierarchical porous biochar (nano-Fe/MC) can be obtained by utilizing K₂FeO₄ as a synchronous activation and graphitization agent. Subsequently, ISA-Fe/MC was achieved by HCl etching of nano-Fe/MC to remove the excess Fe nanoparticles. Compared with nano-Fe/MC, ISA-Fe/MC demonstrated outperformed catalytic capacity towards PMS activation for phenol degradation The combination of super high surface area, hierarchical porous structure, graphitization structure and atomically dispersed Fe species should be responsible for prominent catalytic oxidation ability and outstanding resistance to common anions and humic acid. Based on the chem. scavengers, EPR experiments and electrochem. tests, the SO^â€?₄ dominated radical degradation pathway for nano-Fe/MC and electron transfer reigned non-radical degradation pathway for ISA-Fe/MC was revealed. In contrast to nano-Fe/MC, d. functional theory calculations demonstrated the enhanced d. of states around Fermi level in ISA-Fe/MC meaning the increased catalytic performance and more electron transfer between single-atom Fe to adjacent graphitic C and N which could serve as electron transfer channel for PMS activation.

Journal of Colloid and Interface Science published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Kawale, Harshal D. published the artcileProduction of hydrocarbons from a green algae (Oscillatoria) with exploration of its fuel characteristics over different reaction atmospheres, Safety of 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Energy (Oxford, United Kingdom) (2019), 344-355, database is CAplus.

Authors conducted non-catalytic, catalytic, and hydropyrolysis at 550°C temperature and 1 bar pressure to produce biofuels from an ignored algal biomass of Oscillatoria by thermo-chem. degradation study in a tubular reactor having an internal diameter of 25 mm and 300 mm of active length covered by a furnace of a single heating zone. The catalysts used for the catalytic pyrolysis and hydropyrolysis study are TiO₂:ZnO on 1:1 basis. Characterization of bio-oils by Fourier Transform IR Spectroscopy (FTIR) shows substantial variation in functional groups of all three types of bio-oils. Gas Chromatog.-Mass Spectroscopy (GCMS) gives a detailed list of available hydrocarbons in bio-oil samples and proton NMR confirms the functionality of bio-oil by available proton assignments. Scanning Electron Microscope (SEM) and X-ray Diffraction (XRD) shows morphol. and the structural analogy of biochars with respect to biomass. Calorific values of three types of bio-oils ranges from 16.597 to 16.664 MJ/kg; and revealed that this particular biomass has potential as a resource of feedstock with an approx. yield of one-third of biomass on the dry weight basis. The pH of these bio-oils obtained from green algae varies in the range of 8.25 to 6.07 that indicates the less number of oxygenated compounds unlike very low pH bio-oils obtained from other types of biomass feedstock. Addnl., present results revealed that these bio-oils include formative compounds of most popular hydrocarbons, i.e., benzene, toluene and xylene (BTX). Further, they also include furans, phenols, benzaldehyde, guaiacol, caprolactam, styrene, oximes, etc. which can be used as green chems.

Energy (Oxford, United Kingdom) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Safety of 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Aiba, Motohiro published the artcileEffect of bulky 2,6-bis(spirocyclohexyl)-substituted piperidine rings in bis(hindered amino)trisulfide on thermal healability of polymethacrylate networks, Related Products of piperidines, the publication is Materials Advances (2021), 2(23), 7709-7714, database is CAplus.

This paper describes the synthesis of highly sterically hindered piperidinyl trisulfide with four spirocyclohexyl moieties, bis(2,6-bis[spirocyclohexyl]piperidine-1-yl)trisulfide (BIBSCPS-S3), from com. available starting materials in short steps and its application as a dynamic covalent bond for thermally healable polymer networks. Conformational study on the BIBSCPS-S3 moiety in the solid state is performed by single-crystal X-ray diffraction. In bulk, a stress-relaxation experiment reveals that the increase in steric hindrance can not only decrease the activation energy for thermal exchange reactions but also suppress chain-transfer reactions during radical polymerization to some extent. Therefore, the dynamic crosslinking point containing BIBSCPS-S3 moiety can be efficiently incorporated into polymer networks with Et, Bu, or n-hexyl methacrylate monomers, which is in good accordance with the relatively low chain-transfer constants of the BIBSCPS-S3 moiety determined by the Mayo equation. As a result, BIBSCPS-S3-cross-linked poly(n-hexyl methacrylate) exhibits nearly quant. damage healability only by simple hot pressing at 90°C under mild pressure for 24 h.

Materials Advances published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Related Products of piperidines.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Eslahi, Negin published the artcileCorrelation Study Between Biochemical and Molecular Pathways of Trichoderma harzianum Recombinant Strains on Plant Growth and Health, HPLC of Formula: 826-36-8, the publication is Journal of Plant Growth Regulation (2022), 41(4), 1561-1577, database is CAplus.

The genus of Trichoderma are mostly found in soil. Trichoderma species are known as probiotic with biocontrol and biofertilizer activity. They are producers of secondary metabolites like volatile organic compounds (VOCs) with antifungal, antibacterial, and growth promoter properties. Trichoderma VOCs can induce resistance to plant pathogens leading to improved plant growth and health. In this study, we compared the performance of Trichoderma harzianum recombinant strains (T13 and T15), containing chimeric chit42 with Chitin Binding Domain (ChBD) and wild-type (Tw) strain on plant growth promotion. To achieve this goal, the ability of strains in plant growth-promoting (production of IAA and siderophore) and fungal gene expression involved in biocontrol and biofertilizer activity, as well as, VOCs from T. harzianum strains (wild-type and recombinants) by headspace gas chromatog.-mass spectrometry (GC-SPME) have been investigated. In addition, bean seeds were exposed to the T. harzianum strains in a shared atm. In addition to growth indexes (root fresh and dry weight, root length, and lateral root number), expression of root growth-related genes was measured by qTR-PCR. The results showed that recombinant strains had increased ability to produce IAA and siderophore. In addition, T. harzianum genes expression anal. demonstrated an upregulation in biocontrol and biofertilizer-associated genes in T13 and T15 strains. VOCs profile of strains revealed a total of 11, 57, and 29 metabolites from the Tw, T15, and T13, resp. Most of the VOCs produced from T13 and T15 had growth enhancement and biocontrol activity, resp., on the plant. The diversity of VOCs from T. harzianum recombinant strains (T13 and T15) involved in growth-promoting and biocontrol activity, was higher than the Tw strain. These compounds might work synergistically to promote growth, and enhance biocontrol and antifungal activity, and thus, recombinant strains with higher diversity of VOCs might be more effective than Tw. Plant phenotypic characterization and root genes expression showed that the recombinant strains, T13 particularly, were effective in growth-promoting compared to the Tw strain. In this study, we observed a pos. correlation among the production of secondary metabolite and mol. pathways of recombinant strains on plant growth activity. This finding can create a link between basic and applied studies in agriculture.

Journal of Plant Growth Regulation published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, HPLC of Formula: 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Takajo, Tokuko published the artcileBasic investigations of singlet oxygen detection systems with ESR for the measurement of singlet oxygen quenching activities, Synthetic Route of 826-36-8, the publication is Chemical & Pharmaceutical Bulletin (2020), 68(2), 150-154, database is CAplus and MEDLINE.

Singlet oxygen (¹O₂) is highly oxidative and exerts strong cytotoxic effects. We tried to establish the best combination of a singlet oxygen generation system and a detection method with ESR, for measurement of the quenching activities of various substances. The photosensitizing reaction of rose bengal or thermal decomposition of 4-methyl-1,4-etheno-2,3-benzodioxin-1(4H)-propanoic acid (endoperoxide, EP) was used for the generation of ¹O₂, and a sterically hindered secondary amine, 2,2,6,6-tetramethyl-4-piperidone (TEMPD) or 2,2,6,6-tetramethyl-4-piperidinol (TEMP-OH), was used as the ¹O₂ detection probe. These secondary amines were oxidized by ¹O₂ to form stable nitroxide radicals, which were detectable by ESR. TEMPD was found to be readily oxidized by air, causing large background signals in comparison with TEMP-OH. The ESR signal obtained by the irradiation of rose bengal with visible light in the presence of TEMP-OH consisted of two kinds of nitroxide radical overlapping. In contrast, only a single nitroxide signal was observed when TEMP-OH was reacted with ¹O₂ generated from EP. Therefore, the best combination should be EP as the ¹O₂ generator and TEMP-OH as the detection probe. When using this combination, we found that the concentrations of some organic solvents such as DMSO and acetonitrile should be kept constant for reliable quantification, because the concentrations of organic solvents affect the ESR signal intensity.

Chemical & Pharmaceutical Bulletin published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C8H15NO, Synthetic Route of 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem