Category: 79421-45-7

Application of 79421-45-7, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 79421-45-7, Name is 1-(4-Nitrophenyl)piperidin-4-ol, molecular formula is C11H14N2O3. In a Article，once mentioned of 79421-45-7

The title compound, C11H14N2O3, is a non-linear optical chromophore. The piperidinol ring is in a chair conformation. The C-N-C fragment of the piperidinol moiety is nearly coplanar with the nitrophenyl ring system. The molecular stacking allows hydrogen bonding between the piperidinol hydroxy group and the nitro group.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application of 79421-45-7, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 79421-45-7, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H17925N – PubChem

Related Products of 79421-45-7, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.79421-45-7, Name is 1-(4-Nitrophenyl)piperidin-4-ol, molecular formula is C11H14N2O3. In a article，once mentioned of 79421-45-7

Provided are pyridopyrazine compounds of formula (1), pharmaceutical compositions thereof and methods of use therefore, wherein R1, R2, R3, R4 and m are as defined in the specification.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 79421-45-7, and how the biochemistry of the body works.Related Products of 79421-45-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H17931N – PubChem

Synthetic Route of 79421-45-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 79421-45-7, Name is 1-(4-Nitrophenyl)piperidin-4-ol, molecular formula is C11H14N2O3. In a Article，once mentioned of 79421-45-7

Dimorphic forms of 4-(4-hydroxypiperidinyl)nitrobenzene which are second harmonic generation (SHG) active and inactive are investigated. Crystallization from a variety of solvents clearly demonstrate the preferential formation of the centrosymmetric structure in polar solvents and the noncentrosymmetric structure in nonpolar solvents. Semiempirical quantum chemical calculations including solvation effects on supramolecular fragments of the crystals reveal the solvent selection of the crystalline forms. The potential of this approach to address the general problem of polymorphism in molecular materials is indicated.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Synthetic Route of 79421-45-7, you can also check out more blogs about79421-45-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H17935N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79421-45-7,1-(4-Nitrophenyl)piperidin-4-ol,as a common compound, the synthetic route is as follows.

79421-45-7, A mixture of the yellowish solid (0.90 g, 4.05 mmol) and Pd-C (10%, 120 mg) in MeOH (20 mL) containing aqueous 6N HCl (0.20 mL) was hydrogenated under balloon H2 overnight. It was filtered through celite. The filtrate was concentrated in vacuo to give a solid (0.841 g) as l-(4-aminophenyl)piperidin-4-ol.

79421-45-7 1-(4-Nitrophenyl)piperidin-4-ol 613768, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; PORTOLA PHARMACEUTICALS, INC.; WO2009/131687; (2009); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79421-45-7,79421-45-7, 1-(4-Nitrophenyl)piperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 6 Synthesis of Compound 13 [Show Image] Compound 12 (1.50 g, 6.75 mmol) was dissolved in methanol (25 ml), 10% palladium-carbon (150 mg) was added, and the interior of the system was replaced with a hydrogen gas. After stirred at room temperature for 2 hours, the reaction solution was filtered using Celite, and washed with methanol. The filtrate, and the washing solution were combined, and the solvent was distilled off under reduced pressure to obtain Compound 13 (1.28 g, yield 99%). 1H-NMR (CDCl3 / TMS) deltappm: 1.70-1.80 (m, 2H), 2.07 (br, 2H), 2.84 (br, 2H), 3.37 (br, 3H), 3.85 (br, 1H), 6.65 (d, J = 8.4Hz, 2H), 6.91 (br, 2H).

As the paragraph descriping shows that 79421-45-7 is playing an increasingly important role.

Reference£º
Patent; SHIONOGI & CO., LTD.; EP1988077; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79421-45-7, 1-(4-Nitrophenyl)piperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

79421-45-7, The 4-hydroxy-N-(4-nitrophenyl)piperidine (11.1 g, 50 mmol) obtained in Example 1(1) was dissolved in methanol (100 ml) and tetrahydrofuran (50 ml), and 10% palladium-carbon (8.0 g) was added thereto, followed by stirring at room temperature in an atmosphere of hydrogen gas for 7 hours. After the insoluble material was filtered with Celite, the filtrate was concentrated under reduced pressure, diethyl ether was added to the obtained residue, and the precipitate was collected by filtration, thereby obtaining 4-hydroxy-N-(4-aminophenyl)piperidine (9.25 g, 94%) as a reddish-purple solid.1H-NMR (CDCl3): delta (ppm) 1.65-1.77 (m, 2H), 1.94-2.11 (m, 2H), 2.71-2.85 (m, 2H), 3.23-3.92 (m, 5H), 6.64 (d, J=8.9 Hz, 2H), 6.83 (d, J=8.9 Hz, 2H)

79421-45-7 1-(4-Nitrophenyl)piperidin-4-ol 613768, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; TAIHO PHARMACEUTICAL CO., LTD.; US2011/319413; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79421-45-7, 1-(4-Nitrophenyl)piperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of the yellowish solid (0.90 g, 4.05 mmol) and palladium on carbon (Pd(C)) (10%, 120 mg) in methanol (MeOH) (20 mL) containing aqueous 6N HCl (0.20 mL) was hydrogenated under a balloon of H2 overnight. It was then filtered through celite. The filtrate was concentrated in vacuo to give 1-(4-aminophenyl)piperidin-4-ol as a solid (0.841 g)., 79421-45-7

As the paragraph descriping shows that 79421-45-7 is playing an increasingly important role.

Reference£º
Patent; PORTOLA PHARMACEUTICALS, INC.; US2009/54425; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem