Category: 79098-85-4

Application of 79098-85-4, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 79098-85-4, Name is 3-(Piperidin-4-yl)indolin-2-one hydrochloride, molecular formula is C13H17ClN2O. In a Article，once mentioned of 79098-85-4

We synthesized a series of arylalkyl piperidines (II) carrying a heterocycle at the 4-position of piperidine and examined the hypotensive activities of the products. Compound 23 had the highest hypotensive activity in anesthetized normotensive rats (-78mmHg, 30 mg/kg, i.p.) and compound 12 showed the strongest hypotensive activity (-95 mmHg, 30 mg/kg, p.o.) in unanesthetized spontaneously hypertensive rats. Only compound 16 produced a considerable decrease in blood pressure in both animal models.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application of 79098-85-4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 79098-85-4, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H20878N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79098-85-4,3-(Piperidin-4-yl)indolin-2-one hydrochloride,as a common compound, the synthetic route is as follows.,79098-85-4

EXAMPLE 179 4-(2-Oxo-2,3-dihydroindol-3-yl)-1-(3-phenoxypropyl)piperidine STR215 From a mixture of 4-[2-oxo-2,3-dihydroindol-3-yl)piperidine hydrochloride (198 mg, 0.73 mmol), 3-phenoxy-propyl chloride (476 mg, 2.22 mmol) and K2 CO3 (138 mg) in toluene (15 mL) was obtained 170 mg (70%) of the title compound as a yellow oil, 1 H NMR (CDCl3): 1.42-1.50 (m, 2H), 1.79-2.03 (m, 6H), 2.10-2.15 (m, 1H), 2.47-2.52 (m, 2H), 2.90-3.04 (m, 2H), 3.408 (d, 1H, J=3.5), 7.001 (t, 1H, J=7.5), 7.022 (t, 1H, J=7.5), 7.23-7.29 (m, 3H), 7.909 (s, 1H). The hydrochloride mp 182-3 C.

The synthetic route of 79098-85-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Warner-Lambert Company; Cocensys, Incorporated; US6124323; (2000); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem