Application In Synthesis of 3-(Piperidin-4-yl)benzoic acidOn October 15, 2010 ,《Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Tang, Haifeng; Yan, Yan; Feng, Zhe; de Jesus, Reynalda K.; Yang, Lihu; Levorse, Dorothy A.; Owens, Karen A.; Akiyama, Taro E.; Bergeron, Raynald; Castriota, Gino A.; Doebber, Thomas W.; Ellsworth, Kenneth P.; Lassman, Michael E.; Li, Cai; Wu, Margaret S.; Zhang, Bei B.; Chapman, Kevin T.; Mills, Sander G.; Berger, Joel P.; Pasternak, Alexander. The article contains the following contents:
A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols, e.g. I, were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elevated blood glucose in a murine model of type II diabetes. The results came from multiple reactions, including the reaction of 3-(Piperidin-4-yl)benzoic acid(cas: 766508-67-2Application In Synthesis of 3-(Piperidin-4-yl)benzoic acid)
3-(Piperidin-4-yl)benzoic acid(cas: 766508-67-2) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Application In Synthesis of 3-(Piperidin-4-yl)benzoic acid
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem