Category: 74852-62-3

VITOTOX bacterial genotoxicity and toxicity test for the rapid screening of chemicals was written by Verschaeve, L.;Van Gompel, J.;Thilemans, L.;Regniers, L.;Vanparys, P.;Van der Lelie, D.. And the article was included in Environmental and Molecular Mutagenesis in 1999.Reference of 74852-62-3 This article mentions the following:

The VITOTOX test is a new bacterial genotoxicity test that was previously shown to be very rapid and sensitive. Initially only one Salmonella typhimurium strain (TA104 recN2-4) was used in the test. In this paper the authors introduce a second strain (TA104pr1) that can be used as an internal control to further enhance the reliability of the test. The authors demonstrate the usefulness of this pr1 strain in genotoxicity and toxicity testing. The authors also report on the results of a study where the VITOTOX test was performed on newly synthesized pharmaceutical compounds, or intermediate products in the synthesis of drug candidates. The authors demonstrate that the test gives identical results when performed independently in two different laboratories and that it correlates well with either the Ames test or SOS chromotest. In the experiment, the researchers used many compounds, for example, 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline (cas: 74852-62-3Reference of 74852-62-3).

4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline (cas: 74852-62-3) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Reference of 74852-62-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Inhibition of angiogenesis by the antifungal drug itraconazole was written by Chong, Curtis R.;Xu, Jing;Lu, Jun;Bhat, Shridhar;Sullivan, David J. Jr.;Liu, Jun O.. And the article was included in ACS Chemical Biology in 2007.Quality Control of 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline This article mentions the following:

Angiogenesis, the formation of new blood vessels, is implicated in a number of important human diseases, including cancer, diabetic retinopathy, and rheumatoid arthritis. To identify clin. useful angiogenesis inhibitors, the authors assembled and screened a library of mostly Food and Drug Administration-approved drugs for inhibitors of human endothelial cell proliferation. One of the most promising and unexpected this was itraconazole, a known antifungal drug. Itraconazole inhibits endothelial cell cycle progression at the G1 phase in vitro and blocks vascular endothelial growth factor/basic fibroblast growth factor-dependent angiogenesis in vivo. In attempts to delineate the mechanism of action of itraconazole the authors found that human lanosterol 14α-demethylase (14DM) is essential for endothelial cell proliferation and may partially mediate the inhibition of endothelial cells by itraconazole. Together, these findings suggest that itraconazole has the potential to serve as an antiangiogenic drug and that lanosterol 14DM is a promising new target for discovering new angiogenesis inhibitors. In the experiment, the researchers used many compounds, for example, 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline (cas: 74852-62-3Quality Control of 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline).

4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline (cas: 74852-62-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Quality Control of 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and in Vitro and in Vivo Structure-Activity Relationships of Novel Antifungal Triazoles for Dermatology was written by Meerpoel, Lieven;Backx, Leo J. J.;Van der Veken, Louis J. E.;Heeres, Jan;Corens, David;De Groot, Alex;Odds, Frank C.;Van Gerven, Frans;Woestenborghs, Filip A. A.;Van Breda, Andre;Oris, Michel;Van Dorsselaer, Pascal;Willemsens, Gustaaf H. M.;Vermuyten, Karen J. P.;Marichal, Patrick J. M. G.;Vanden Bossche, Hugo F.;Ausma, Jannie;Borgers, Marcel. And the article was included in Journal of Medicinal Chemistry in 2005.Recommanded Product: 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline This article mentions the following:

In search for new compounds with potential for clin. use as antifungal agents in dermatol., a series of 12 azole compounds, e.g. I, were synthesized stereospecifically and investigated specifically for their activity against dermatophyte fungal infections in animal models. This panel of azoles was studied in vitro and compared with itraconazole and terbinafine for their antifungal activity using a panel of 24 Candida spp. and 182 dermatophyte isolates. Three azoles (I, II, and III) showed in vitro antifungal potency equivalent to itraconazole, but superior to terbinafine, against a panel of 24 Candida spp. With comparable or lower activity than that of itraconazole and terbinafine against 182 dermatophyte isolates and only rare activity against other pathogenic fungi. However, in vivo I and III, both given orally, demonstrated antifungal activity at least three times greater than itraconazole and were superior compared to terbinafine in M. canis infected guinea pigs. In a mouse model infected by T. mentagrophytes, again III, but not I, showed 5-fold superior activity over itraconazole and terbinafine. Compound II was effective in both models but less effective than itraconazole in these models. On the basis of these promising results, III is currently being clin. investigated for its potential as a novel antifungal agent against dermatophytosis. In the experiment, the researchers used many compounds, for example, 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline (cas: 74852-62-3Recommanded Product: 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline).

4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline (cas: 74852-62-3) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Recommanded Product: 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics