Category: 72831-89-1

Nomoto, Yuji; Obase, Hiroyuki; Takai, Haruki; Hirata, Tadashi; Teranishi, Masayuki; Nakamura, Joji; Kubo, Kazuhiro published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Studies on cardiotonic agents. I. Synthesis of some quinazoline derivatives》.Electric Literature of C13H16N2O The author mentioned the following in the article:

A series of quinazoline derivatives with various 4-heterocyclylpiperidino groups at the 4-position was synthesized and tested for cardiotonic activity in anesthetized dogs. E.g., reaction of 6-acetamido-4-chloro-7-methoxyqinazoline and 4-(2-oxo-1-imidazolidinyl)piperidine gave quinazoline derivative I. Among them, several 6,7-dimethoxyquinazoline derivatives showed potent cardiotonic activity. In the part of experimental materials, we found many familiar compounds, such as 3-(Piperidin-4-yl)indolin-2-one(cas: 72831-89-1Electric Literature of C13H16N2O)

3-(Piperidin-4-yl)indolin-2-one(cas: 72831-89-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Electric Literature of C13H16N2O

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthetic Route of C13H16N2OOn September 30, 1983 ,《New antihypertensive agents. III. Synthesis and antihypertensive activity of some arylalkyl piperidines carrying a heterocycle at the 4-position》 was published in Chemical & Pharmaceutical Bulletin. The article was written by Obase, Hiroyuki; Nakamizo, Nobuhiro; Takai, Haruki; Teranishi, Masayuki; Kubo, Kazuhiro; Shuto, Katsuichi; Kasuya, Yutaka; Shigenobu, Koki; Hashikami, Makiko. The article contains the following contents:

Arylalkyl piperidines carrying a heterocycle at the 4-position of piperidine e.g. I, II, III, and IV were prepared and the hypotensive activities of the products examined Thus, 2-indolinone was treated with 1-benzyl-4-piperidinone followed by hydrogenolysis to give 4-(2-oxoindolin-3-yl)piperidine which was treated with 2-bromo-3′,4′-methylenedioxyacetophenone to give IV. Compound I had the highest hypotensive activity in anesthetized normotensive rats (-78 mmHg, 30 mg/kg, i.p.) and compound II showed the strongest hypotensive activity (-95 mmHg, 30 mg/kg p.o) in unanesthetized spontaneously hypertensive rats. Only III produced a considerable decrease in blood pressure in both animal models. In the experiment, the researchers used 3-(Piperidin-4-yl)indolin-2-one(cas: 72831-89-1Synthetic Route of C13H16N2O)

3-(Piperidin-4-yl)indolin-2-one(cas: 72831-89-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Synthetic Route of C13H16N2O

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Salvino, Joseph M.; Kumar, N. Vasant; Orton, Edward; Airey, John; Kiesow, Terence; Crawford, Kenneth; Mathew, Rose; Krolikowski, Paul; Drew, Mark; Engers, Darren; Krolinkowski, David; Herpin, Tim; Gardyan, Michael; McGeehan, Gerald; Labaudiniere, Richard published their research in Journal of Combinatorial Chemistry on December 31 ,2000. The article was titled 《Polymer-Supported Tetrafluorophenol: A New Activated Resin for Chemical Library Synthesis》.COA of Formula: C13H16N2O The article contains the following contents:

A new tetrafluorophenol activated resin that facilitates the use of 19F NMR to quantitate loading is presented. This new resin provides a useful tool for acylation, and a novel activated polymeric sulfonate ester to generate sulfonamides. This activated resin reacts with a wide scope of N-nucleophiles including primary and secondary amines, and anilines. This new activated resin methodol. provides a powerful tool for pure single-compound library synthesis. In addition to this study using 3-(Piperidin-4-yl)indolin-2-one, there are many other studies that have used 3-(Piperidin-4-yl)indolin-2-one(cas: 72831-89-1COA of Formula: C13H16N2O) was used in this study.

3-(Piperidin-4-yl)indolin-2-one(cas: 72831-89-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. COA of Formula: C13H16N2O

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem