Category: 72752-52-4

72752-52-4, 2-Piperidinobenzonitrile is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2; 3-methyl-1-(2-(1-piperidinyl)phenyl)butylamine; This amine was obtained from the nitrile intermediate according to protocol B. It was isolated by silica gel chromatography (dichloromethane/methanol 95/5). Yield: 79%

72752-52-4, As the paragraph descriping shows that 72752-52-4 is playing an increasingly important role.

Reference：
Patent; GENFIT; US2006/79696; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72752-52-4,2-Piperidinobenzonitrile,as a common compound, the synthetic route is as follows.

Example 3-6; 2-(2-(1-piperidinyl)phenyl)hexanoic acid; This acid was prepared in 3 steps from 2-(1-piperidinyl)benzonitrile intermediate (see example 2-1). Step 1; 1-(2-(1-piperidinyl)phenyl)pentan-1-ol; Under anhydrous atmosphere, 2-(1-piperidinyl)benzonitrile (15 g, 80.5 mmol) was solubilized in anhydrous THF (75 ml) and freshly prepared butylmagnesium bromide (242 mmol in 100 ml THF) was added. The mixture was refluxed overnight. The crude was then hydrolyzed with water and acidified with 1M HCl until a pH close to 7 was obtained. The resulting ketone was extracted with ethyl acetate, dried with magnesium sulfate (MgSO4), and concentrated. The residue was taken in methanol (150 ml) and the solution was cooled with an ice bath. Sodium borohydride (6.1 g, 161 mmol) was added portionwise at 0 C. and the crude was warmed to room temperature. Upon total ketone consumption (according to TLC), water was added and the expected compound was extracted with ethyl acetate, dried with magnesium sulfate (MgSO4), and concentrated. The expected product was isolated by silica gel chromatography (cyclohexane/ethyl acetate 95/5). Yield: 55%, 72752-52-4

The synthetic route of 72752-52-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; GENFIT; US2006/79696; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72752-52-4,2-Piperidinobenzonitrile,as a common compound, the synthetic route is as follows.

72752-52-4, To a well stirred suspension of magnesium turnings (67.7 g, 2.80 mol) in THF (30 mL), benzyl chloride (l mL) and catalytic amount of iodine was added at 25-30 C. The contents were stirred for 30 min at 35-40 C. Thereafter, a solution of benzyl chloride (306.0 g, 2.40 mol) dissolved in a mixture of THF (150 mL) and toluene (450 mL) was added, mainraining the intemal temperature of reaction mixture in between 35-45 C. Stirred the reaction mixture for another 2h at 35-40 C and cooled to 25-30 C. Thereafter a solution of nitrile 4 (150,0 g, 0.80 mol) dissolved in THF (150 mL) and toluene (450 mL) was added at 25-45 C. The reaction mixture was cooled to 25-30 C and stirred for 16 h at 25-30 C. The above suspension was added over a mixture of aqueous NH4CI (25% wlw, 600 mL) and aqueous ammonia (300 mL) at 5-15 C. The inorganics were removed through filtration and washed with water (250 mL). The organic layer was separated and concentrated under vacuum to obtained 9 (204.4 g).

As the paragraph descriping shows that 72752-52-4 is playing an increasingly important role.

Reference：
Article; Sundaram, Dhanraj T. S. S.; Mitra, Jayati; Rajesh; Islam, Aminul; Prabahar, Koilpillai Joseph; Rao, Battula Venkateswara; Douglas, Sanasi Paul; Synthetic Communications; vol. 45; 18; (2015); p. 2092 – 2098;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

72752-52-4, 2-Piperidinobenzonitrile is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,72752-52-4

General procedure: Intermediates benzylamino (Figures 2) Protocol A: to a solution of 2-substituted benzonitrile (1 eq.) in THF (50 mL for 50 mmol of starting material) was added phenyl magnesium bromide 1 M (2 eq.) at rt under N2 atmosphere. After completion of the imine formation, MeOH was added to quench the excess of Grignard reagent at 0C. Then, reducing agent (either NaBH4/MeOH, Zn/AcOH, Zn/ammonium acetate/am monia/EtOH or ammonium formate/Pd(OH)2/EtOH) (1 .5 eq. – 2 eq.) was added either directly to the reaction mixture or imine intermediate was isolated before. The reaction was stirred at rt or gently heated at 40-60C. The completion of the reaction was monitored by TLC.

The synthetic route of 72752-52-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; GENFIT; DELHOMEL, Jean-Francois; WALCZAK, Robert; MAJD, Zouher; PIHAN, Emilie; BONNET, Pascal; PERSPICACE, Enrico; (198 pag.)WO2016/102633; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72752-52-4,2-Piperidinobenzonitrile,as a common compound, the synthetic route is as follows.

72752-52-4, A mixture of iBuMgBr (2 M in diethyl ether, 1.6 l, 3.2 mol) and toluene (1.6 1) was heated to a temperature of about 87C under nitrogen atmosphere. Then a solution of 2-piperidino-benzonitril (300 g, 1.6 mol) in toluene (1.6 1) was slowly added to the hot mixture within 1h, while maintaining the temperature. Thereafter, the reaction mixture was heated to reflux at a temperature of about 103-105C for 3h. After cooling the mixture to 0C, 1.6 1 of methanol were slowly added to this mixture. The resulting mixture was stirred for another hour at about 0-5C. Then NaBH4 (121 g, 3.2 mol) was added successively within 1h. Thereafter, the mixture was stirred for another hour at 15C and for another 2 hours at room temperature. Then 1.6 1 of THF was added and the mixture was stirred over night. The precipitated salts were filtrated and washed with THF (2 x 400 ml) and water (2 x 1.6 1) twice. The filtrate was dried and evaporated in vacuo to give 352 g of a crude yellow oil, which was then dissolved in 2-propanole (3.2 1). This solution was heated to a temperature of about 50C, at which 180 g of glutaric acid was slowly added. The product precipitated from this solution was stirred for 2h at room temperature and for 2h at 0-5C. After filtration and washing with cold 2-propanole (300 ml), the wet product was dried in a vacuum drier at 60C for 18h, to give 463 g (76%) of the desired product.

72752-52-4 2-Piperidinobenzonitrile 2774355, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Krka Tovarna Zdravil, D.D., Novo Mesto; EP2177221; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

72752-52-4, 2-Piperidinobenzonitrile is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 3-5; 4-methyl-2-(2-(1-piperidinyl)phenyl)pentanoic acid; This acid was synthesized in 3 steps from the intermediate 2-(1-piperidinyl)benzonitrile (see example 2-1). Step 1; 3-methyl-1-(2-(1-piperidinyl)phenyl)butan-1-ol; Under anhydrous atmosphere, 2-(1-piperidinyl)benzonitrile (10 g, 53.7 mmol) was solubilized in anhydrous THF (50 ml). Freshly prepared isobutylmagnesium bromide (83 ml at 3.9 mol/l in THF, 324 mmol) was added and the mixture was refluxed overnight. The mixture was hydrolyzed with water and acidified by a 1M HCl solution until pH 7. The resulting ketone was extracted by ethyl acetate, dried with magnesium sulfate (MgSO4), and evaporated. The residue was solubilized in methanol (100 ml) and the solution was cooled with an ice bath. Sodium borohydride (7.1 g, 188 mmol) was added portionwise at 0 C. and the reaction was slowly warmed to room temperature. Once the ketone was reduced, water was added and the alcohol was extracted by ethyl acetate, dried with magnesium sulfate (MgSO4) and evaporated. The expected product was purified by silica gel chromatography (cyclohexane/ethyl acetate 95/5). Yield: 60%, 72752-52-4

72752-52-4 2-Piperidinobenzonitrile 2774355, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; GENFIT; US2006/79696; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem