Category: 71985-80-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71985-80-3,1-Methylpiperidine-4-carboxylic acid hydrochloride,as a common compound, the synthetic route is as follows.,71985-80-3

(iv) Methyl [3-({[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9- yl)propyl][(l-methylpiperidin-4-yl)carbonyl]amino}methyl)phenyl]acetate; 5 The product from step (iii) (O.lg), diisopropyl ethylamine (0.1ml) and l-methylpiperidine-4- carboxylic acid hydrochloride (45mg) were dissolved in NMP (3ml) then etaATU (130mg) added to the mixture. The mixture was stirred at rt for 5h then purified by SCX and RPetaPLC, which afforded the title compound. Yield 70mg.1H NMR delta (DMSO- d6) 7.23 (IH, t), 7.12 (IH, d), 7.03 (IH, s), 7.02 (IH, d), 6.15 (2H, brs), o 4.50 (2H, s), 4.16 (2H, t), 3.65 (2H, t), 3.61 (2H, s), 3.60 (3H, s), 3.25 (2H, t), 2.68 (2H, m),2.10 (3H, s), 1.86- 1.96 (2H, m), 1.63 (5H, m), 1.42 (4H, m), 0.91 (3H, t).MS: APCI (+ve): 568 (M+l).

71985-80-3 1-Methylpiperidine-4-carboxylic acid hydrochloride 2760043, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ASTRAZENECA AB; DAINIPPON SUMITOMO PHARMA CO., LTD; WO2008/4948; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71985-80-3,1-Methylpiperidine-4-carboxylic acid hydrochloride,as a common compound, the synthetic route is as follows.,71985-80-3

48 mg (0.26 mmol) 1-methyl-piperidine-4-carboxylic acid hydrochloride were dissolved in 5 ml thionyl chloride and heated to reflux for 30 min. The excess thionyl chloride was removed by evaporation and the resulting acid chloride dissolved in 5 ml methylene chloride. This solution was added to a solution of 100 mg (0.25 mmol) 3-(3-amino-4-trifluormethoxy-phenyl) -5,5-dimethyl-1-pyridin-4-ylmethyl-imidazolidine-2,4-dione and 111 mg (0. 68mmol) huenig’s base and the mixture was stirred overnight at RT and heated to reflux for 1h. The mixture was poured on saturated sodium bicarbonate solution, extracted with ethylacetate, then dried and evaporated. The residue was was purified by preparative HPLC. (C18 reversed phase column, elution with a water (0.1% trifluoracetic acid) /acetonitrile gradient) Yield: 10 mg MS(ES+): m/e = 520 LC/MS Retention time [min] = 0.86

As the paragraph descriping shows that 71985-80-3 is playing an increasingly important role.

Reference：
Patent; Aventis Pharma S.A.; EP1621536; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem