Category: 71985-80-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71985-80-3,1-Methylpiperidine-4-carboxylic acid hydrochloride,as a common compound, the synthetic route is as follows.

Example A10; N-[[3-(4-amino-1-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-7-yl)phenyl]methyl]-1-methyl-4-piperidinecarboxamide; A mixture of A9.3 (13 mg; 0.03 mmol), 1-methylpiperidine-4-carboxylic acid hydrochloride salt (8 mg; 0.04 mmol), EDC (12 mg; 0.06 mmol), 1-hydroxybenztriazole (6 mg; 0.04 mmol) and diisopropylethylamine (0.028 ml; 0.15 mmol) in MDF (0.5 ml) was heated to 60 C. for 0.5 hrs. After the volatiles were removed in vacuo, the residue was dissolved in a small volume of TFA and heated to 60 C. for 2 hrs. After removing the volatiles in vacuo, the residue was purified by preparative HPLC to afford 15 mg (94%) of A10 as a light yellow solid. 1H-NMR (DMSO-d6) delta: 8.74 (2H, brs), 8.64 (1H, t, J=5.5 Hz), 8.48 (1H, s), 7.77 (1H, s), 7.73 (1H, d, J=8 Hz), 7.68 (1H, s), 7.50 (1H, t, J=7.5 Hz), 7.33 (1H, d, J=8 Hz), 4.37 (2H, d, J=5.5 Hz), 4.04 (1H, s), 3.47 (2H, m) 2.97 (2H, m), 2.78 (4H, m), 1.95 (2H, m), 1.80 (2H, m). HPLC (A): 99%, ret. time 1.10 min., LC/MS (M+H)+=435.32.

71985-80-3, As the paragraph descriping shows that 71985-80-3 is playing an increasingly important role.

Reference：
Patent; Pitts, William J.; Das, Jagabandhu; Qiu, Yuping; Spergel, Steven H.; US2006/178393; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71985-80-3,1-Methylpiperidine-4-carboxylic acid hydrochloride,as a common compound, the synthetic route is as follows.

71985-80-3, Example 8; Synthesis of 2-(benzhvdryl(methylamino)-l-(4-((l-methylpiperidin-4- yl)(phenyl)methyl)piperazin-l-yl)ethanone (compound no. 14); A. Synthesis of (l-methylpiperidin-4-yl)(phenyl)methanone[0096] l-Methylpiperidine-4-carboxylic acid hydrochloride salt 10 g (55.7mmol) was added to thionyl chloride (25 ml) and stirred at room temperature until the solid dissolved completely. The reaction mixture was stirred for another 20 minutes and concentrated. The product was used for the next step without further purification.[0097] To a cooled suspension of anhydrous aluminum chloride (20 g, 75 mmol) in benzene 30 ml at 00C was added l-methylpiperidine-4-carboxylic acid chloride in small portions and the resulting mixture was refluxed for 3 hours. The reaction mixture was then cooled down by adding to ice water. The organic phase was discarded. The aqueous solution was washed with 2×50 ml ethyl ether, basified with potassium hydroxide pellet slowly to pH >10 and extracted with ethyl ether 4×50 ml. The combined ethereal solution was dried over sodium sulfate and concentrated to give 9.5 g of desired product in 84% yield.

The synthetic route of 71985-80-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NEUROMED PHARMACEUTICALS LTD.; WO2007/71035; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

71985-80-3, 1-Methylpiperidine-4-carboxylic acid hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

71985-80-3, N-Methylisonipecotic acid hydrochloride ( 0.5 g) was dissolved in dry SOC12 (1.5 mL). The mixture was then heated at 80 C for 2 hours under argon. Cooling and evaporation to dryness afforded a yellow solid which was used without further purification.

The synthetic route of 71985-80-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; TAXIS PHARMACEUTICALS, INC.; LAVOIE, Edmond J.; PARHI, Ajit; PILCH, Daniel S.; ZHANG, Yongzheng; KAUL, Malvika; WO2014/74932; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71985-80-3,1-Methylpiperidine-4-carboxylic acid hydrochloride,as a common compound, the synthetic route is as follows.

Procedure J Example 90: N-{4-[1,3-benzoxazol-2(3H)-ylidene(cyano)methyl]-2-pyrimidinyl}-2- METHYL-4-PIPERIDINECARBOXAMIDE To a suspension of (2-AMINO-4-PYRIMIDINYL) (1, 3-benzoxazol-2 (3H)-YLIDENE) ethanenitrile (100.00 mg; 0.40 mmol), 1-METHYL-PIPERIDINE-4-CARBOXYLIC acid HCl (107.25 MG ; 0.60 mmol) and 2-CHLORO-1-METHYLPYRIDINIUM iodide (203.37 MG ; 0.80 mmol) in THE (4.00 ML) was added DIEA (0.34 ML ; 1.99 mmol) and the resulting suspension was heated up to 150C under microwave conditions during 900s (normal absorption, 9 bar). After ON standing at 4C, the precipitate formed was filtered off and washed thoroughly with THE then water. After drying at 40C for 2 days, the solid was taken up in DCM to which TFA was added Ether in excess was added and the precipitate obtained was filtered off and washed with ether (3x) then dried under vacuum at 40C. The solid was purified by preparative HPLC to afford after lyophilisation the title compound as a yellow fluffy solid (19%). 1H NMR (METHANOL-D4) 5 : 8.15-7. 95 (m, 1H), 7.47-7. 10 (m, 4H), 6. 83-6. 65 (m, 1H), 3.65- 3. 30 (m, 4H), 3. 16-3. 08 (m, 3H), 3.07-2. 90 (M, 1H), 2.42-1. 90 (M, 4H) M (ES): 375.1 ; M+(ES) : 377.1 ; HPLC (max plot) 98. 1% ; Rt : 2. 00min.

71985-80-3, The synthetic route of 71985-80-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2005/26159; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

71985-80-3, 1-Methylpiperidine-4-carboxylic acid hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

71985-80-3, 1-Methylpiperidine-4-carboxylic acid hydrochloride salt 10 g (55.7 mmol) was added to thionyl chloride (25 ml) and stirred at room temperature until the solid dissolved completely. The reaction mixture was stirred for another 20 minutes and concentrated. The product was used for the next step without further purification. 1-Methylpiperidine-4-carboxylic acid hydrochloride salt 10 g (55.7 mmol) was added to thionyl chloride (25 ml) and resulting mixture stirred at room temperature until the solid dissolved completely. The reaction mixture was stirred for another 20 minutes and concentrated. The product was used for the next step without further purification.; EXAMPLE 5 Synthesis of N-benzhydryl-4-((4-chlorophenyl)(1-methylpiperidin-4-yl)methyl)piperazine-1-carboxamide A. Synthesis of 1-Methylpiperidine-4-carboxylic acid chloride 1-Methylpiperidine-4-carboxylic acid hydrochloride salt 10 g (55.7 mmol) was added to thionyl chloride (25 ml) and resulting mixture stirred at room temperature until the solid dissolved completely. The reaction mixture was stirred for another 20 minutes and concentrated. The product was used for the next step without further purification.

71985-80-3 1-Methylpiperidine-4-carboxylic acid hydrochloride 2760043, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; NeuroMed Technologies Inc.; US2006/63775; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

71985-80-3, 1-Methylpiperidine-4-carboxylic acid hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

71985-80-3, 0-(1 H-BENZOTRIAZOL-1-YL)-N, N, N’, N’-tetramethyluronium hexafluorophosphate (395 mg, 1.04 MMOL) was added to a solution of 1-methylpiperidine-4-carboxylic acid hydrochloride (210 mg, 1.04 MMOL) in dichloromethane (10 ml) and the solution stirred for 30 minutes. The amine from example 4 (200 mg, 0.52 MMOL) was added and the reaction mixture was stirred at room temperature for 18 hours. The mixture was washed with aqueous sodium carbonate solution and the organic solution was dried over magnesium sulphate. The solution was evaporated under reduced pressure and the crude product was purified by column chromatography on silica gel using ethyl acetate: methanol : 0. 88 ammonia (90: 10: 1) as eluant, to afford the title compound as a white solid (195 mg). APCI MS M/Z 506 [MH] +

As the paragraph descriping shows that 71985-80-3 is playing an increasingly important role.

Reference：
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/74291; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

71985-80-3, 1-Methylpiperidine-4-carboxylic acid hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

71985-80-3, EXAMPLE 234; J/V-r4-(6.6-Dimethyl-4-oxo-4.5.6.7-tetrahvdrori,31thiazolor5.4-clpyridin-2-ylV3.4- dihydro-2H- 1 ,4-benzoxazin-7-yl]- 1 -methylpiperidine-4-carboxamide; To a stirred solution of Example 233 (0.049 g, 0.15 mmol), 2-(lH-benzotriazol-l- yl)-l,l,3,3-tetramethyluronium hexafluorophosphate (0.111 g, 0.29 mmol) and 1 -methyl – piperidine-4-carboxylic acid hydrochloride (0.034 g, 0.19 mmol) in DMF (0.5 mL) was added DIPEA (0.06 mL, 0.35 mmol). The reaction mixture was stirred at r.t. for 16 h. MeCN (1 mL) and water (1 mL) were added. The insoluble material was filtered, and the filtrate concentrated in vacuo. Purification by preparative etaPLC (Method 6) gave the title compound (0.035 g, 51%) as a yellow solid. deltaeta (CD3OD) 7.91 (IH, d, J9.0 Hz), 7.37 (IH, d, J 2.3 Hz), 7.11 (IH, dd, J 8.9 and 2.3 Hz), 4.40-4.30 (2H, m), 4.20-4.09 (2H, m), 3.62 (2H, d, J 12.6 Hz), 3.17-3.02 (2H, m), 2.92 (3H, s), 2.89 (2H, s), 2.76-2.60 (IH, m), 2.34-1.91 (4H, m), 1.39 (6H, s). Exchangeable protons were not observed. LCMS (ES+) 456.21 (M+H)+, RT 1.80 minutes (Method I).

The synthetic route of 71985-80-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; UCB PHARMA S.A.; WO2008/1076; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

71985-80-3, 1-Methylpiperidine-4-carboxylic acid hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,71985-80-3

Example 252; 1 -Methyl-piperidine-4-carboxylic acid ((S)-I -{2-[6-cyano-3-(4-methoxy- benzenesulfonyl)-2-oxo-2,3-dihydro-benzoimidazol-1 -yl]-2 -phenyl -acetyl}- pyrrolidin-3-yl)-amide; compound with trifluoroacetic acid; A mixture of i-methylpiperidine-4-carboxylic acid hydrochloride (16 mg, 0.09 mmol), 1-hydroxybenzotriazole (15 mg, 0.11 mmol) and PS-carbodiimide resin (Argonaut; 1.25 mmol/g; 72 mg, 0.09 mmol) in CH2CI2 (3 ml.) was agitated for 10 min at room temperature. Then, 3-[2-((S)-3-amino-pyrrolidin-1 -yl)-2-oxo-1 -phenyl-ethyl]-1 -(4- methoxy-benzenesulfonyl)-2-oxo-2,3-dihydro-1 H-benzoimidazole-5-carbonitrile (40 mg, 0.08 mmol) was added and the reaction mixture was agitated at room temperature overnight. To this was then added MP-carbonate resin (Argonaut; 3.08 mmol/g; 73 mg, 0.23 mmol) and the reaction mixture was agitated for another 2 hours, filtered and concentrated in vacuo. The residue was purified by preparative RP-HPLC (eluent: gradient from 10% to 80% acetonitrile in water, 0.1% trifluoroacetic acid as modulator) to afford 1 -methyl-piperidine-4-carboxylic acid ((S)- 1-{2-[6-cyano-3-(4-methoxy-benzenesulfonyl)-2-oxo-2,3-dihydro-benzoimidazol-1-yl]- 2-phenyl-acetyl}-pyrrolidin-3-yl)-amide; compound with trifluoroacetic acid (13 mg, 21%) as a white solid.1H-NMR (500 MHz, DMSOd6): delta 1.61-2.04 (m, 5H), 2.15-2.33 (m, 1 H), 2.77 (m, 3H), 2.90 (m, 2H), 3.11 (m, 1 H), 3.27 (m, 1 H), 3.42-3.98 (m, 6H), 3.87 (s, 3H), 6.32-6.42 (m, 1 H), 6.97-7.10 (m, 1 H), 7.20 (dd, 9.1 Hz, 2.4 Hz, 2H), 7.22-7.30 (m, 2H), 7.39 (m, 3H), 7.61-7.65 (m, 1 H), 7.97 (dd, 8.5 Hz, 4.7 Hz, 1 H), 7.99-8.03 (m, 2H). MS (API-ES, pos) m/z = 657.20 [M+H]+.

As the paragraph descriping shows that 71985-80-3 is playing an increasingly important role.

Reference：
Patent; ABBOTT GMBH & CO. KG; WO2008/25736; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

71985-80-3,71985-80-3, 1-Methylpiperidine-4-carboxylic acid hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 91 (0.5 g, 4.1 mmol) in DMF (37 mL) was added diisopropylethylamine (2.54 mL, 14.6 mmol) 92 (0.5 g, 4.1 mmol) and PyBOP (2.53 g, 4.87 mmol). The mixture was stirred at rt for 17 h, TLC (MeOH) showed two major components. The reaction solution was diluted with water and the aquesous layer was extracted with EtOAc. The organic extracts were combined, dried (MgSO4), filtered and concentratetd in vacuo to afford an oil. The crude was purified by flash column chromatography to afford 93 (0.9 g, 90%).

71985-80-3 1-Methylpiperidine-4-carboxylic acid hydrochloride 2760043, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Infinity Pharmaceuticals, Inc.; US2006/25460; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

71985-80-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71985-80-3,1-Methylpiperidine-4-carboxylic acid hydrochloride,as a common compound, the synthetic route is as follows.

N-Methylisonipecotic acid hydrochloride (0.5 g) was dissolved in dry SOCl2 (1.5 mL) The mixture was then heated at 80 C. for 2 hours under argon. Cooling and evaporation to dryness afforded a yellow solid which was used without further purification.

71985-80-3 1-Methylpiperidine-4-carboxylic acid hydrochloride 2760043, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; LaVoie, Edmond J.; Parhi, Ajit; Pilch, Daniel S.; Zhang, Yongzheng; Kaul, Malvika; US2015/133465; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem