Category: 7149-42-0

7149-42-0,7149-42-0, (1-Methylpiperidin-4-yl)methanamine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The mixture of N-((4-chloro-3-nitrophenyl)sulfonyl)-4-(4-((4′-chloro-5,5-dimethyl- 3,4,5,6-tetrahydro-[l, l’-biphenyl]-2-yl)methyl)piperazin- l-yl)-2-(5-((2- (trimethylsilyl)ethoxy)methyl)pyrazolo[4,3-b]pyrrolo[3,2-e]pyridin- l(5H)-yl)benzamide (200.00 mg, 211.86 mupiiotaomicron, 1.00 eq) and (l-methyl-4-piperidyl)methanamine (81.49 mg, 635.58 //mol, 3.00 eq) were dissolved in CH3CN (10.00 mL), to which DIEA (82.14 mg, 635.58 mupinuomicronChi, 111.00 /L, 3.00 eq) was added in one portion. The resulting mixture was taken up into a microwave tube and heated at 80 C under N2 atmosphere for 2 h. The reacting solution was poured onto silica gel chromatography and eluted with pure DCM to (0281) DCM:MeOH = 5: 1 to afford crude 4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[l, l’- biphenyl]-2-yl)methyl)piperazin- l-yl)-N-((4-(((l-methylpiperidin-4-yl)methyl)amino)-3- nitrophenyl)sulfonyl)-2-(5-((2-(trimethylsilyl)ethoxy)methyl)pyrazolo[4,3-b]pyrrolo[3,2- e]pyridin- l(5H)-yl)benzamide (50.00 mg, 48.27 mupiiotaomicron, 22.79% yield) as a yellow oil which was confirmed by LC-MS.

The synthetic route of 7149-42-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NEWAVE PHARMACEUTICAL INC.; CHEN, Yi; (94 pag.)WO2017/132474; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

7149-42-0, (1-Methylpiperidin-4-yl)methanamine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7149-42-0, A solution of the appropriate chloride (1 eq) (ex: 5-chloro-6-methyl-3-(3- trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1 ,2,3a,4,6-pentaaza-cyclopenta- (ajnaphthalene) and the appropriate amine (3 to 5 eq) (ex: 1-methyl-piperidin-4- ylamine) in nBuOH (15 mL/mmol) was heated up to 180- 185C under microwave irradiation for 5 h – 10 h (or 24 h at 160-180C in a silicon bath). The solvent was evaporated under vacuum and the residue was purified by flash chromatography (Isolute/Flash, Sill, 2.5% MeOH with 7N ammonia in DCM) or by semi-preparative HPLC (Gemini C18 (150 10 mm; 5 m), Solvent A: water with 0.1 % formic acid; Solvent B: acetonitrile with 0.1 % formic acid. Gradient: 40% of A to 0% of A).The NH-BOC-protected amines got deprotected in the reaction conditions and reacted giving a mixture of regioisomers. Amine: (1-methyl-4-piperidinyl)methanamineHPLC-MS (method 1): Rt=2.74 min, [ +H]+m/z 419.2.1H NMR (300 MHz, eOD) delta 8.80 (s, 1 H), 8.46 (d, J = 8.1 , 1 H), 8.34 (s, 1 H), 7.73 (d, J = 7.7, 1 H), 7.60 (t, J = 7.9, 1H), 4.43 – 4.35 (m, 2H), 3.44 (d, J = 12.1, 2H), 3.28 (d, J = 6.9, 2H), 3.19 – 3.14 (m, 2H), 3.00 (t, J = 11.5, 2H), 2.76 (s, 3H), 2.68 (s, 3H), 2.24 (s, 1 H), 2.08 (d, J = 10.8, 2H), 1.51 (d, J = 11.7, 2H).

7149-42-0 (1-Methylpiperidin-4-yl)methanamine 81574, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); GARCIA COLLAZO, Ana Maria; PASTOR FERNANDEZ, Joaquin; BLANCO APARICIO, Carmen; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; RAMOS LIMA, Francisco Javier; HERNANDEZ HIGUERAS, Ana Isabel; SALUSTE, Carl-Gustave Pierre; GONZALEZ CANTALAPIEDRA, Esther; MARTINEZ GONZALEZ, Sonia; SALGADO SERRANO, Antonio; NOYA MARINO, Beatriz; WO2011/80510; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7149-42-0,(1-Methylpiperidin-4-yl)methanamine,as a common compound, the synthetic route is as follows.

7149-42-0, A solution of the appropriate chloride (1 eq) (ex: 5-chloro-6-methyl-3-(3- trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1 ,2,3a,4,6-pentaaza-cyclopenta- (ajnaphthalene) and the appropriate amine (3 to 5 eq) (ex: 1-methyl-piperidin-4- ylamine) in nBuOH (15 mL/mmol) was heated up to 180- 185C under microwave irradiation for 5 h – 10 h (or 24 h at 160-180C in a silicon bath). The solvent was evaporated under vacuum and the residue was purified by flash chromatography (Isolute/Flash, Sill, 2.5% MeOH with 7N ammonia in DCM) or by semi-preparative HPLC (Gemini C18 (150 10 mm; 5 m), Solvent A: water with 0.1 % formic acid; Solvent B: acetonitrile with 0.1 % formic acid. Gradient: 40% of A to 0% of A).The NH-BOC-protected amines got deprotected in the reaction conditions and reacted giving a mixture of regioisomers. Amine: (1-methyl-4-piperidinyl)methylamineHPLC-MS (method 1 ): Rt = 3.28 min, [M+H]+ m/z 492.1. NMR (300 MHz, DMSO-d6) delta 8.58 (s, 1 H), 8.43 (d, J = 7.9 Hz, 1 H), 8.20 (s, 1 H), 7.69 (m, 1 H), 7.49 (m, 1 H), 6.91 (s, 1H), 4.46 (m, 1 H), 3.20 (m, 4H), 2.80 (m, 2H), 2.70 (s, 3H), 2.17 (s, 3H), 1.89 (m, 3H), 1.72 (m, 2H), 1.46 (d, J = 6.2 Hz, 3H), 1.25 (m, 2H).

As the paragraph descriping shows that 7149-42-0 is playing an increasingly important role.

Reference£º
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); GARCIA COLLAZO, Ana Maria; PASTOR FERNANDEZ, Joaquin; BLANCO APARICIO, Carmen; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; RAMOS LIMA, Francisco Javier; HERNANDEZ HIGUERAS, Ana Isabel; SALUSTE, Carl-Gustave Pierre; GONZALEZ CANTALAPIEDRA, Esther; MARTINEZ GONZALEZ, Sonia; SALGADO SERRANO, Antonio; NOYA MARINO, Beatriz; WO2011/80510; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7149-42-0,(1-Methylpiperidin-4-yl)methanamine,as a common compound, the synthetic route is as follows.

7149-42-0, (Z)-4-(((l -Acetyl-6-(methoxycarbonyl)-5-methyl-2-oxoindolin-3-ylidene) (phenyl)methyl)ami no)benzoic acid, trifluoroacetate adduct (Intermediate E) (75 mg,0.128 mmol) and HATU (73.2 mg, 0.192 mmol) in DMF (2 mL) were stirred at rt for 10 mm.Then Hunig?s base (179 p1, 1.02 mmol) and (1-methylpiperidin-4-yl)methanamine (32.9 mg,0.257 mmol) in DMF (0.2 mL) were added. The mixture was stirred at rt for 16 h. Piperidine(127 p1, 1.28 mmol) was added. The mixture was stirred at RT for 4 h and the reaction mixture was partitioned between DCM (25 mL) and saturated aqueous NaHCO3 solution (10 mL). The organic layer was washed with brine (10 mL) and the solvent was evaporated under reduced pressure. The crude product was purified by preparative HPLC (Method A, 20-50% MeCN in water) to afford the title compound (Z)-methyl 5-methyl-3-(((4-(((1 -methyl piperidin-4-yl)methyl)carbamoyl) phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate, formate as a light yellow solid (19 mg, 25%); Rt 1.55 mm (Method 1); mlz 539 (M+H) (ES); 1H NMR O: 1.11-1.28 (2H, overlapping m), 1.53 (1H, m), 1.60-1.73 (2H, overlapping m), 2.13 (3H, 5), 2.15-2.24 (2H, overlapping m), 2.34 (3H, 5), 2.89-3.00 (2H, overlapping m), 3.09 (2H, t), 3.75 (3H, 5), 5.61 (1H, 5), 6.87 (2H, m), 7.36 (1H, 5), 7.52 (2H, m), 7.58-7.69 (5H, overlapping m),8.17 (1H, 5), 8.36 (1H, t), 10.88 (1H, 5), 12.23 (1H, 5).

7149-42-0 (1-Methylpiperidin-4-yl)methanamine 81574, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; RESPIVERT LIMITED; WALTERS, Iain; BIRCH, Louise; COLLINGWOOD, Stephen, Paul; STEVENSON, Christopher, Scott; (110 pag.)WO2017/153748; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

7149-42-0, (1-Methylpiperidin-4-yl)methanamine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7149-42-0, The intermediate 3-cyano-4-(4-methoxy-4-methyl-piperidin-1-yl)-2-oxo-1,2-dihydro-1,7-naphthyridine-6-carboxylic acid (200 mg, 0.58mmol, 1.0eq), was dissolved in anhydrous N, N- dimethylacetamide (2mL), DIPEA (226.3mg, 1.75mmol, 3.0eq) and HATU (333.1mg, 0.88mmol, 1.5eq), was added and stirred at room temperature 0.5 ~ 1h. a solution of (1-methyl-piperidin-4-yl)methanamine (150mg, 1.17mmol, 2.0eq), the reaction at room temperature 1h. LC-MS monitoring starting material still remaining supplemented with (1-methyl-piperidin-4-yl) methanamine (150mg, 1.17mmol, 2.0eq), the reaction was continued 2h, and purified by preparative HPLC (0.1% aqueous trifluoroacetic acid 30:: acetonitrile = 70) to give product (68.8mg, yield: 20.7%).

As the paragraph descriping shows that 7149-42-0 is playing an increasingly important role.

Reference£º
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Li Lin; Yang Xiaoju; (118 pag.)CN109575016; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7149-42-0,(1-Methylpiperidin-4-yl)methanamine,as a common compound, the synthetic route is as follows.

12. Scheme for the Synthesis of 7-29 . Scheme 613. Synthesis of N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy) phenyl imidazofi ,2-blpyridazin-6-amine (Compound 7-29):[0148] To the toluene (5 mL) solvent was added 7-12 (40 mg, 0.128 mmol), (1-methylpiperidin-4-yl)methanamine (24.53 0.191 mmol), ligand (7.53 mg, 0.019 mmol), Pd2(dba)3 (8.76, 9.56 mmol) and NaOfBu (17.40 mg, 0.181 mmol). The resulting reaction mixture was degassed for 10 min under argon and then was heated to reflux overnight (12 h). The crude product was EPO concentration and preparative TLC was performed with 10% MeOH/DCM solvent system afforded 17.6 mg of 7-23 (50%)., 7149-42-0

The synthetic route of 7149-42-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUPERGEN, INC.; WO2008/58126; (2008); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7149-42-0,(1-Methylpiperidin-4-yl)methanamine,as a common compound, the synthetic route is as follows.

General procedure: Exam le: Synthesis of final product 1A mixture of (1-methyl-4-piperidinyl)methanamine (101 mg, 0.78 mmol) and Intermediate 1-42 (100 mg, 0.26 mmol) in DMA (5 mL) was heated at 100 C for 8 h. The solvents were removed in vacuo and the residue was purified by column chromatography (DCM/7N NH3 in MeOH 100:0 to 98:2). The product obtained was triturated from Et20 to afford Final Product 1 (32 mg) as a white solid., 7149-42-0

The synthetic route of 7149-42-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); MCNEENEY, Stephen, Phillip; PASTOR FERNANDEZ, Joaquin; MARTINEZ GONZALES, Sonia; MARTIN HERNANDO, Jose Ignacio; RODRIGUEZ HERGUETA, Antonio; RICO FERREIRA, Maria del Rosario; BLANCO APARICIO, Carmen; WO2013/4984; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem