Category: 71486-53-8

Simple exploration of 71486-53-8

The synthetic route of 71486-53-8 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71486-53-8,Methyl 4-oxopiperidine-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

71486-53-8, Referential Example 8 1.94 g of methyl 4-oxo-3-piperidinecarboxylate hydrochloride, 1.68 g of sodium hydrogencarbonate and 1.67 g of ethyl bromoacetate were dissolved in a mixed solvent comprising 32 ml of water and 8 ml of diethyl ether and stirred at room temperature overnight. 50 ml of ethyl acetate was added to the reaction liquid, and the organic layer was separated by liquid-liquid separation. This was dried with sodium sulfate and concentrated. The resulting residue was purified by silica gel column chromatography (using a gradient eluent of chloroform to chloroform/methanol=100/1) to obtain 1.5 g of ethyl 3-methoxycarbonyl-4-oxo-1-piperidineacetate as an oily substance. Mass spectrum (m/z): FAB (Pos) 244(M+ +1) NMR spectrum (CDCl3, TMS internal standard):

The synthetic route of 71486-53-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US5773442; (1998); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Brief introduction of 71486-53-8

The synthetic route of 71486-53-8 has been constantly updated, and we look forward to future research findings.

71486-53-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71486-53-8,Methyl 4-oxopiperidine-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

A mixture of 20 gm (103.3 mMol) methyl 4-oxo-3-piperidinecarboxylate hydrochloride and 75 mL saturated aqueous sodium bicarbonate in 150 mL dichloromethane was stirred vigorously at room temperature. A solution of 24.8 gm (113.6 mMol) di-tert-butyl dicarbonate in 100 mL dichloromethane was then added dropwise over three hours. After stirring at room temperature for about 16 hours, an additional 3.0 gm di-tert-butyl dicarbonate were added and stirring continued for an additional 2 hours. The reaction mixture was then diluted with water and extracted with 2 x 250 mL dichloromethane. The organic phases were combined, dried over magnesium sulfate, and concentrated under reduced pressure to provide 26.2 gm (99percent) of the desired compound as a yellow oil.

The synthetic route of 71486-53-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; EP1204659; (2003); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem