Category: 7037-49-2

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 7037-49-2, name is 3-(Piperidin-4-yl)propan-1-ol, introducing its new discovery. Computed Properties of C8H17NO

Type 5 17beta-hydroxysteroid dehydrogenase (17beta-HSD5), also known as aldo-keto reductase 1C3 (AKR1C3), is a member of the aldo-keto reductase superfamily of enzymes and is expressed in the human prostate. One of the main functions of 17beta-HSD5 is to catalyze the conversion of the weak androgen, androstenedione, to the potent androgen, testosterone. The concentration of intraprostatic 5alpha-dihydrotestosterone (DHT) in patients following chemical or surgical castration has been reported to remain as high as 39% of that of healthy men, with 17beta-HSD5 shown to be involved in this androgen synthesis. Inhibition of 17beta-HSD5 therefore represents a promising target for the treatment of castration-resistant prostate cancer (CRPC). To investigate this, we conducted high-throughput screening (HTS) and identified compound 2, which displayed a structure distinct from known 17beta-HSD5 inhibitors. To optimize the inhibitory activity of compound 2, we first introduced a primary alcohol group. We then converted the primary alcohol group to a tertiary alcohol, which further enhanced the inhibitory activity, improved metabolic stability, and led to the identification of compound 17. Oral administration of compound 17 to castrated nude mice bearing the CWR22R xenograft resulted in the suppression of androstenedione (AD)-induced intratumoral testosterone production. Compound 17 also demonstrated good isoform selectivity, minimal inhibitory activity against either CYP or hERG, and enhanced pharmacokinetic and physicochemical properties.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 7037-49-2 is helpful to your research. Computed Properties of C8H17NO

Reference：
Piperidine – Wikipedia,
Piperidine | C5H8179N – PubChem

 

Related Products of 7037-49-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.7037-49-2, Name is 3-(Piperidin-4-yl)propan-1-ol, molecular formula is C8H17NO. In a Article，once mentioned of 7037-49-2

Inhibition of the cell cycle kinase, cyclin-dependent kinase-4 (Cdk4), is expected to provide an effective method for the treatment of proliferative diseases such as cancer. The pyrido[2,3-d]-pyrimidin-7-one template has been identified previously as a privileged structure for the inhibition of ATP-dependent kinases, and good potency against Cdks has been reported for representative examples. Obtaining selectivity for individual Cdk enzymes, particularly Cdk4, has been challenging. Here, we report that the introduction of a methyl substituent at the C-5 position of the pyrido[2,3-d]pvrimidin-7-one template is sufficient to confer excellent selectivity for Cdk4 vs other Cdks and representative tyrosine kinases. Further optimization led to the identification of highly potent and selective inhibitors of Cdk4 that exhibit potent antiproliferative activity against human tumor cells in vitro. The most selective Cdk4 inhibitors were evaluated for antitumor activity against MDA-MB-435 human breast carcinoma xenografts in mice.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 7037-49-2 is helpful to your research. Related Products of 7037-49-2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H8201N – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 7037-49-2, name is 3-(Piperidin-4-yl)propan-1-ol, introducing its new discovery. Application In Synthesis of 3-(Piperidin-4-yl)propan-1-ol

A piperidine derivative of general formula (I) or a pharmaceutically acceptable salt thereof: STR1 wherein STR2 is any of several specified aromatic-containing groups; X is selected from one of several hetero atom-containing groups or C2 alkylene or a cyano-containing group; and Q is phenyl, cyclohexyl, piperidinyl, tetrahydropyranyl, pyridyl, pyrrolyl, N-methylpyrrolyl, thienyl, furyl, 1-hexyl, or cyano; from 1 to 3 hydrogen atoms in Q may be independently substituted by alkyl of from 1 to 3 carbon atoms, perfluoroalkyl of from 1 to 3 carbon atoms, acylamino of from 1 to 6 carbon atoms, perfluoroacylamino of from 1 to 3 carbon atoms, alkoxy of from 1 to 3 carbon atoms, alkanesulfonylamino of from 1 to 3 carbon atoms, perfluoroalkanesulfonylamino of from 1 to 3 carbon atoms, acetoxy of from 1 to 3 carbon atoms, aminocarbonyl, aminosulfonyl, fluoro, chloro, cyano, hydroxy, nitro, amino, imidazolylmethyl, cinnamoylamino, p-fluorobenzoyl, cyanomethyl, cyanoethyl, methoxyacetoxy, alkoxycarbonyl of from 1 to 3 carbon atoms; 1 is an integer of from 0 to 1; m is an integer of from 0 to 1; n is an integer of from 0 to 6. The derivatives are useful as antiarrhythmic agents.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 7037-49-2 is helpful to your research. Application In Synthesis of 3-(Piperidin-4-yl)propan-1-ol

Reference：
Piperidine – Wikipedia,
Piperidine | C5H8214N – PubChem

 

Application of 7037-49-2, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 7037-49-2, Name is 3-(Piperidin-4-yl)propan-1-ol,introducing its new discovery.

PROCESS FOR THE PREPARATION OF OXADIAZOLES

Process for the preparation of oxadiazoles, useful as intermediates in the preparation of biologically active molecules.

If you¡¯re interested in learning more about 4837-90-5, below is a message from the blog Manager. Application of 7037-49-2

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H8196N – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 7037-49-2, name is 3-(Piperidin-4-yl)propan-1-ol, introducing its new discovery. name: 3-(Piperidin-4-yl)propan-1-ol

N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR beta AGONISTS, COMPOSITIONS, AND THEIR USE

Provided herein are certain substituted N-aryl and N-heteroaryl piperidine compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, L, R4, L1, Q, R5 and R 6 are as defined. The said novel compounds, and pharmaceutically acceptable compositions comprising a compound thereof, may be useful as Liver X-beta receptor(LXRbeta) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory disease and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer’s disease.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 7037-49-2 is helpful to your research. name: 3-(Piperidin-4-yl)propan-1-ol

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H8195N – PubChem

 

Electric Literature of 7037-49-2, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 7037-49-2, name is 3-(Piperidin-4-yl)propan-1-ol. In an article£¬Which mentioned a new discovery about 7037-49-2

[4-(Benzo[B]Thiophen-2-Yl) Pyrimidin-2-Yl]-Amine Derivatives As Ikk-Beta Inhibitors For The Treatment Of Cancer And Inflammatory Diseases

The present invention provides compounds of Formula I: useful in the treatment of cancer and inflammatory diseases.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.7037-49-2. In my other articles, you can also check out more blogs about 7037-49-2

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H8187N – PubChem