Category: 7006-50-0

7006-50-0, 4-(Methylamino)-1-benzylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7006-50-0, b) 18.9 g of 1-benzyl-4-methylaminopiperidine as the oil prepared according to a) are taken up in 250 ml of methanol and combined with 8.3 g of cyclopropanecarboxaldehyde and 11.3 g of sodium cyanoborohydride. The mixture is stirred for 5 hours at 40-50 C., then for about another 16 hours at ambient temperature. It is then acidified with 2 N hydrochloric acid, evaporated to dryness in vacuo and the residue is taken up in water. It is washed with ether, made alkaline with concentrated sodium hydroxide solution and extracted with ether/ethyl acetate. The organic extract is dried over sodium sulphate and freed from the solvents in vacuo. 22.7 g 1-benzyl-4-(cyclopropylmethyl-methyl-amino)-piperidine are obtained as a yellowish oil.

As the paragraph descriping shows that 7006-50-0 is playing an increasingly important role.

Reference：
Patent; Pairet, Michel; Pieper, Michael P.; Meade, Christopher J. M.; US2002/169181; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7006-50-0,4-(Methylamino)-1-benzylpiperidine,as a common compound, the synthetic route is as follows.

7006-50-0, To a solution of the 1H-indazole-5-carboxylic acid (281 mg, 1.73 mmol) obtained in Reference Example 1 in N,N-dimethylformamide (10 ml) were added 1-benzyl-N-methylpiperidin-4-amine (390 mg, 1.91 mmol), triethylamine (0.29 ml, 2.08 mmol), 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide monohydrochloride (499 mg, 2.60 mmol) and hydroxybenzotriazole (281 mg, 2.08 mmol), and the resulting mixture was stirred overnight at room temperature. An aqueous sodium hydrogencarbonate solution was added to the reaction solution, followed by extraction with chloroform, and the organic layer was dried over anhydrous magnesium sulfate. The solvent was concentrated under reduced pressure and the resulting residue was purified by a silica gel column chromatography (eluent: chloroform/ethyl acetate ? chloroform/methanol) to obtain N-(1-benzylpiperidin-4-yl)-N-methyl-1H-indazole-5-carboxamide (502 mg, 83%).1H-NMR (DMSO-d6) delta; 1.61 (2H, m), 1.78 (2H, m), 2.83 (5H, m), 3.39 (2H, s), 7.29 (6H, m), 7.57 (1H, d, J=8.5Hz), 7.78 (1H, s), 8.12 (1H, s), 13.22 (1H, s).

As the paragraph descriping shows that 7006-50-0 is playing an increasingly important role.

Reference：
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1403255; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

7006-50-0, 4-(Methylamino)-1-benzylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 15; 2- (3-chlorophenoxy)-N-methyl-N- [1- ( {1- [4- (tritluoromethyl) phenyl]-1H-pyrrol-3- yl} methyl) piperidin-4-yl] acetamide; i) N- (I-benzylpiperidin-4-yl)-2-chloro-N-methylacetamide; Chloroacetyl chloride (1. 1 mL, 14 mmol) was added dropwise to a stirred solution of 1- benzyl-N-methylpiperidin-4-amine (2.5 g, 12 mmol, prepared as described by Russell, M. G. N. et al. J. Med. Chem, 1999, 42, 4981) in DCM (50 mL) at 0 C. The mixture was stirred for 1 h at rt. whereupon additional DCM (100 mL) was added and the organic phase was washed with NaHCO3 (50 mL, aq. , sat. ), dried over MgS04 and concentrated to give 3.4 g (quant. ) of the title compound as a thick slightly yellow oil which was used in the next step without further purification. ‘H NMR (DMSO-d6, complex rotameric mixture, * denotes minor rotamer peaks) 8 7.20- 7. 38 (m, 5H), 4. 40* (s, 2H), 4.35 (s, 2H), 4.18 (m, 1H), 3. 58* (m, 1H), 3. 48* (s, 2H), 3.47 (s, 2H), 2.88 (br s, 1H), 2.84 (s, 3H), 2. 72* (s, 3H), 1.95-2. 12 (m, 2H), 1.56-1. 84 (m, 3H), 1.43 (m, 2H). MS (ESI) 281.3 (M + H+)., 7006-50-0

The synthetic route of 7006-50-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ASTRAZENECA AB; WO2005/90330; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7006-50-0,4-(Methylamino)-1-benzylpiperidine,as a common compound, the synthetic route is as follows.

7006-50-0, b) 18.9 mug of 1-benzyl-4-methylaminopiperidine as the oil prepared according to a) are taken up in 250 ml of methanol and combined with 8.3 g of cyclopropanecarboxaldehyde and 11.3 g of sodium cyanoborohydride. The mixture is stirred for 5 hours at 40-50 C., then for about another 16 hours at ambient temperature. It is then acidified with 2 N hydrochloric acid, evaporated to dryness in vacuo and the residue is taken up in water. It is washed with ether, made alkaline with concentrated sodium hydroxide solution and extracted with ether/ethyl acetate. The organic extract is dried over sodium sulphate and freed from the solvents in vacuo. 22.7 g 1-benzyl-4-(cyclopropylmethyl-methyl-amino)-piperidine are obtained as a yellowish oil.

The synthetic route of 7006-50-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Boehringer Ingelheim Pharma GmbH & Co. Kg; US2005/148562; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7006-50-0,4-(Methylamino)-1-benzylpiperidine,as a common compound, the synthetic route is as follows.,7006-50-0

Preparation 21; N-(1-Benzy(piperidin-4-yl)-N-methyipyridin-2-amine A mixture of 4-methylamino-1-benzylpiperidine; [(1.5g, 6.2mmol), J. Med. Chem. 39, 3769-89; 1996] 1-bromopyridine (0.98g, 6.2mmol), sodium tert-butoxide (0.68g, 7.3mmol), 1,3-bis(diphenylphosphino)propane (102mg, 0.24mmol) and tris (dibenzylideneacetone)dipalladium(O) (113mg, 0.12mmol) in toluene (20mL) was heated under reflux for 4 hours. Tlc analysis showed that there was still starting material present and so further bromopyridine (0.49g, 3.1 mmol), tris (dibenzylideneacetone)dipalladium(0) (113mg, 0.12mmol), bis(diphenylphosphino)propane (102mg, 0.24mmol) and sodium tert-butoxide (0.68g, 7.3mmol) were added and heating continued for a further 3 hours. The mixture was then diluted with dichloromethane and washed with brine. The organic solution was dried over magnesium sulfate and concentrated in vacuo and the residue was purified by column chromatography on silica gel, eluting with dichloromethane: methanol: 0. 88 ammonia, 90: 10:1 to afford the title compound in 40% yield, 0.69g.

7006-50-0 4-(Methylamino)-1-benzylpiperidine 4136128, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/105779; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem