Category: 664362-16-7

664362-16-7, 1-Boc-3-Ethynylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INTERMEDIATE 35 (METHOD V); 3-Ethynylpiperidine hydrochloride; To Intermediate 33 (1.50 g, 7.18 mmol) was added HCl (4iVm dioxane, 50 mL). The reaction mixture was stirred at r.t. for 16 h and concentrated in vacuo. Trituration with Et2O gave the title compound (0.91 g, 86%). deltaH (DMSOd6) 9.02 (2H, br. s), 3.38- 3.24 (IH, m), 3.21-3.08 (2H, m), 2.94-2.76 (3H, m), 2.00-1.87 (IH, m), 1.83-1.73 (IH, m), 1.73-1.60 (IH, m), 1.60-1.48 (IH, m).

664362-16-7, The synthetic route of 664362-16-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; UCB PHARMA S.A.; WO2007/141504; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

664362-16-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.664362-16-7,1-Boc-3-Ethynylpiperidine,as a common compound, the synthetic route is as follows.

Hydrochloric acid (gas) (excess) wasbubbled through a mixture of tert-butyl 3-ethynylpiperidine-1-carboxylate (90mg, 0.43 mmol) in dichloromethane (5 mL) at 0oC for 15 minutes. Thesolvent was evaporated under reduced pressure to give the 3-ethynylpiperidinehydrochloride (50 mg, yield: 80%) as white solid which was used directlywithout further purification. MS (M+H)+ = 110.3

664362-16-7 1-Boc-3-Ethynylpiperidine 21963855, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Schwaid, Adam G.; Ruangsiriluk, Wanida; Reyes, Allan R.; Cabral, Shawn; Rajamohan, Francis; Tu, Meihua; Ward, Jessica; Carpino, Philip A.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 1993 – 1996;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem