Category: 66207-08-7

Miles, Timothy J. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2011 | CAS: 66207-08-7

N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane (cas: 66207-08-7) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Product Details of 66207-08-7

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases was written by Miles, Timothy J.;Axten, Jeffrey M.;Barfoot, Christopher;Brooks, Gerald;Brown, Pamela;Chen, Dongzhao;Dabbs, Steven;Davies, David T.;Downie, David L.;Eyrisch, Susanne;Gallagher, Timothy;Giordano, Ilaria;Gwynn, Michael N.;Hennessy, Alan;Hoover, Jennifer;Huang, Jianzhong;Jones, Graham;Markwell, Roger;Miller, William H.;Minthorn, Elizabeth A.;Rittenhouse, Stephen;Seefeld, Mark;Pearson, Neil. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Product Details of 66207-08-7 This article mentions the following:

We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this series and advanced studies on compound 8. Compound 8 possesses good pharmacokinetics, broad spectrum antibacterial activity and demonstrates oral efficacy in a rat lung infection model. In the experiment, the researchers used many compounds, for example, N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane (cas: 66207-08-7Product Details of 66207-08-7).

N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane (cas: 66207-08-7) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Product Details of 66207-08-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Schramm, Heiko et al. published their research in Synthesis in 2009 | CAS: 66207-08-7

N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane (cas: 66207-08-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Name: N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane

Straightforward and scalable synthesis of orthogonally protected 3,7-diazabicyclo[4.1.0]heptane was written by Schramm, Heiko;Pavlova, Maria;Hoenke, Christoph;Christoffers, Jens. And the article was included in Synthesis in 2009.Name: N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane This article mentions the following:

Orthogonally N-protected (Boc and Cbz) 3,4-aziridinopiperidine is a versatile building block for the synthesis of 4-substituted 3-aminopiperidines, which are compounds with a high potential for biol. activity. A multigram synthesis over five steps, starting with extraordinarily simple materials (pyridine and benzyl chloride), was developed. In the experiment, the researchers used many compounds, for example, N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane (cas: 66207-08-7Name: N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane).

N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane (cas: 66207-08-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Name: N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Newhouse, Bradley J. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2011 | CAS: 66207-08-7

N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane (cas: 66207-08-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Recommanded Product: N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane

Non-oxime pyrazole based inhibitors of B-Raf kinase was written by Newhouse, Bradley J.;Hansen, Joshua D.;Grina, Jonas;Welch, Mike;Topalov, George;Littman, Nicole;Callejo, Michele;Martinson, Matthew;Galbraith, Sarah;Laird, Ellen R.;Brandhuber, Barbara J.;Vigers, Guy;Morales, Tony;Woessner, Rich;Randolph, Nikole;Lyssikatos, Joseph;Olivero, Alan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Recommanded Product: N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane This article mentions the following:

The synthesis and biol. evaluation of non-oxime pyrazole based B-Raf inhibitors is reported. Several oxime replacements have been prepared and have shown excellent enzyme activity. Further optimization of fused pyrazole 2a led to compound 38 (I), a selective and potent B-Raf inhibitor. In the experiment, the researchers used many compounds, for example, N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane (cas: 66207-08-7Recommanded Product: N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane).

N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane (cas: 66207-08-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Recommanded Product: N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem