Category: 63921-23-3

63921-23-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63921-23-3,1-Phenylpiperidin-4-amine,as a common compound, the synthetic route is as follows.

Example 21 (397mg, lmmol), 1-phenylpiperidin-4-ylamine (176mg, Immol) and silver acetate (167mg, lmmol) in acetonitrile (20ml) were heated at reflux overnight. The reaction mixture was evaporated, purified by column chromatography on silica using 2-10% methanol in dichloromethane as the eluant, followed by mass triggered HPLC purification using an acid based eluant. The free base was liberated using a strong cation exchange cartridge to give the desired compound (40mg). 1H NMR 8 (ppm) 400MHz (CDC13), 1.45-1. 52 (2 H, m), 2.00-2. 13 (4 H, m), 2.32- 2.52 (5 H, m), 2.74-2. 80 (2 H, m), 3.25-3. 31 (2 H, m), 3.37-3. 46 (1 H, m), 3.55-3. 76 (4 H, m), 6.82-6. 93 (5 H, m), 7.14 (1 H, dd, J = 4.7, 7.4Hz), 7.23-7. 27 (2 H, m), 7.48 – 7. 52 (3 H, m), 8.37 (1 H, d, J = 4.3Hz). MSp m/z for MH+ =540.

63921-23-3 1-Phenylpiperidin-4-amine 21193347, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; MERCK SHARP & DOHME LIMITED; WO2005/51390; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

63921-23-3, 1-Phenylpiperidin-4-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

63921-23-3, (1) Preparation of phenyl N-(1-phenyl-4-piperidyl)carbamate pyridine (24 muL) and phenyl chlorocarbonate (32 muL) were added to a solution of 1-phenyl-4-piperidylamine (35 mg) in tetrahydrofuran (1 ML), and the mixture was stirred at room temperature for 12 hours.. The reaction mixture was poured into saturated aqueous sodium bicarbonate, and extracted with ethyl acetate.. The organic layer was dried over anhydrous magnesium sulfate and concentrated.. The residue was purified by column chromatography on silica gel (ethyl acetate/chloroform = 1/1) to give the title compound (37 mg).

The synthetic route of 63921-23-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1415986; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

63921-23-3, 1-Phenylpiperidin-4-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

This example illustrates the preparation of (1-benzyl-piperidin-4-yl)-carbamic acid 2-[7-(4-fluoro-phenoxy)-2,5-dioxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-3-methyl-butyl ester. Alcohol 63 was obtained according to steps a-e described in Example 21. Alcohol 63 (0.11 g, 0.3 mmol) in DCM (1 mL) was treated with p-nitrophenylchloroformate (0.12 g, 0.6 mmol.) and 4-methylmorpholine (0.12 g, 1.2 mmol) for 3 h at 0 C., then the reaction was quenched with sodium bicarbonate and extracted with EtOAc. The organic layer was washed with sodium bicarbonate and brine, dried and concentrated to yield 0.15 g carbonate 69, which was allowed to react with 4-amino-1-benylpiperidine to yield the title compound.

63921-23-3, As the paragraph descriping shows that 63921-23-3 is playing an increasingly important role.

Reference：
Patent; Amgen Inc.; US2006/199796; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem