Category: 635713-68-7

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Formula: C12H15N3O, Which mentioned a new discovery about 635713-68-7

The invention relates to the CGRP antagonists of general formula (I), wherein A and R1 to R3 are defined as indicated in claim 1, the tautomers, diastereomers, enantiomers, hydrates, mixtures and salts thereof, the hydrates of the salts, especially the physiologically acceptable salts thereof with inorganic or organic acids, medicaments containing said compounds, the use thereof, and methods for the production thereof

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Related Products of 635713-68-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.635713-68-7, Name is 1’H-Spiro[piperidine-4,4′-quinazolin]-2′(3’H)-one, molecular formula is C12H15N3O. In a Patent，once mentioned of 635713-68-7

The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

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Application of 635713-68-7, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.635713-68-7, Name is 1’H-Spiro[piperidine-4,4′-quinazolin]-2′(3’H)-one, molecular formula is C12H15N3O. In a article，once mentioned of 635713-68-7

We report the synthesis of rigid spirocyclic systems as conformationally constrained variants of the Ala-Phe-NH2 dipeptide amide C-terminus of the calcitonin gene-related peptide (CGRP). CGRP receptor antagonists containing these moieties displayed potent affinity, functional antagonism and excellent oxidative stability. Structure-activity relationship studies demonstrated the relative importance of hydrogen bond donor/acceptor functionalities and the preferred orientation of an aromatic ring. Antagonists showed potent and full reversal of CGRP-induced dilation of ex vivo human intracranial arteries.

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Piperidine – Wikipedia,
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Chemistry is traditionally divided into organic and inorganic chemistry. name: 1’H-Spiro[piperidine-4,4′-quinazolin]-2′(3’H)-one. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 635713-68-7

The present invention relates to novel CGRP antagonists of the general formula (I) in which U, V, X, Y, R1, R2, R3 are defined as described below, the tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts thereof, and the hydrates of the salts, particularly the physiologically compatible salts thereof having inorganic or organic acids or bases, pharmaceuticals comprising said compounds, the use thereof, and the method for the production thereof.

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Reference：
Piperidine – Wikipedia,
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