Brief introduction of 1-Cyclopropylpiperidin-4-one

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Synthetic Route of 62813-01-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.62813-01-8, Name is 1-Cyclopropylpiperidin-4-one, molecular formula is C8H13NO. In a article,once mentioned of 62813-01-8

Substituted benzamide compounds corresponding to formula (I) in which R5, R6, R7, R8, a, b, c, d, t, D and X have defined meanings, a process for their preparation, pharmaceutical compositions comprising such compounds, and a method of using such compounds to treat pain and other conditions mediated at least in part via the bradykinin 1 receptor.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H6496N – PubChem

 

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Synthesis and biological evaluation of allylated mono-carbonyl analogues of curcumin (MACs) as anti-cancer agents for cholangiocarcinoma

A series of new allylated mono-carbonyl curcumin analogues (MACs) were designed and synthesized. In vitro cytotoxic activities of allylated MACs 6a?h together with previously reported analogues 4a?i and 7a?e, were tested against human cholangiocarcinoma cell lines including HUCCA, QBC-939 and RBE. Of all the compounds tested, 6c exhibited potent in vitro antiproliferative activity against the three tested cancer cell lines with IC50values of 8.7, 9.3 and 8.9 muM, respectively. Cell cycle analysis showed that 6c inhibited cell proliferation due to G2/M arrest. Furthermore, mechanistic studies revealed that 6c dose-dependently increased the level of Bax and inhibited the expression of Bcl-2, to induce cancer cell apoptosis. Taken together, this work provides a novel series of anti-cancer candidates for the treatment of cholangiocarcinoma.

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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H6508N – PubChem

 

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 62813-01-8, name is 1-Cyclopropylpiperidin-4-one, introducing its new discovery. 62813-01-8

NOVEL COMPOUNDS

There is provided a compound of formula (I): processes for the manufacture thereof, pharmaceutical compositions thereof and uses in therapy

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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H6479N – PubChem