Category: 622-26-4

In 2015,Iwasaki, Takanori; Shimizu, Ryohei; Imanishi, Reiko; Kuniyasu, Hitoshi; Kambe, Nobuaki published 《Copper-catalyzed regioselective hydroalkylation of 1,3-dienes with alkyl fluorides and Grignard reagents》.Angewandte Chemie, International Edition published the findings.Synthetic Route of C7H15NO The information in the text is summarized as follows:

Copper complexes generated in situ from CuCl2, alkyl Grignard reagents, and 1,3-dienes play important roles as catalytic active species for the 1,2-hydroalkylation of 1,3-dienes by alkyl fluorides through C-F bond cleavage. The alkyl group is introduced to an internal carbon atom of the 1,3-diene regioselectively, thus giving rise to the branched terminal alkene product.2-(Piperidin-4-yl)ethanol(cas: 622-26-4Synthetic Route of C7H15NO) was used in this study.

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Synthetic Route of C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2013,Iwasaki, Takanori; Takagawa, Hiroaki; Singh, Surya P.; Kuniyasu, Hitoshi; Kambe, Nobuaki published 《Co-Catalyzed Cross-Coupling of Alkyl Halides with Tertiary Alkyl Grignard Reagents Using a 1,3-Butadiene Additive》.Journal of the American Chemical Society published the findings.Computed Properties of C7H15NO The information in the text is summarized as follows:

In the presence of cobalt(II) chloride, lithium iodide, and either 1,3-butadiene or isoprene, alkyl Grignard reagents with β-hydrogen atoms such as tert-butylmagnesium chloride underwent coupling reactions with alkyl tosylates, fluorides, bromides, and iodides such as 1-bromooctane in THF at 50° to give alkanes such as 2,2-dimethyldecane in 55-91% isolated yields or in 58-95% GC yields; sterically congested quaternary carbon centers could be constructed by using tertiary alkyl Grignard reagents. Ester-, amide-, and tetrahydropyran-containing alkyl bromides were compatible with the reaction conditions. Coupling reactions of 6-bromo-1-hexene and cyclopropylmethyl bromide did not yield cyclized product and gave low yields (<4%) of ring-opened products, resp., while reaction in the presence of 9,10-dihydroanthracene gave product in low yield but with complete recovery of dihydroanthracene, implying that the coupling does not occur through radical intermediates. An ionic mechanism with inversion of stereochem. at the reacting site of the alkyl halide is proposed for the coupling reaction based on the stereoselectivity of reaction of a racemic dideuterated phenethyl bromide. The experimental part of the paper was very detailed, including the reaction process of 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Computed Properties of C7H15NO)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Computed Properties of C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Formula: C7H15NOIn 2020 ,《Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c’]dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer’s disease and other tauopathies》 appeared in European Journal of Medicinal Chemistry. The author of the article were Gabellieri, Emanuele; Capotosti, Francesca; Molette, Jerome; Sreenivasachary, Nampally; Mueller, Andre; Berndt, Mathias; Schieferstein, Hanno; Juergens, Tanja; Varisco, Yvan; Oden, Felix; Schmitt-Willich, Heribert; Hickman, David; Dinkelborg, Ludger; Stephens, Andrew; Pfeifer, Andrea; Kroth, Heiko. The article conveys some information:

The compound screening was initiated with a direct staining assay to identify compounds binding to Tau aggregates and not Abeta plaques using human brain sections derived from late stage Alzheimer’s disease donors. The binding of Tau aggregate selective compounds was then quant. assessed with human brain derived paired helical filaments utilizing the label-free Back Scattering Interferometry assay. In vivo biodistribution experiments of selected fluorine-18 labeled compounds were performed in mice to assess brain uptake, brain washout, and defluorination. Compound 11 emerged as the most promising candidate, displaying high in vitro binding affinity and selectivity to neurofibrillary tangles. Fluorine-18 labeled compound 11 showed high brain uptake and rapid washout from the mouse brain with no observed bone uptake. Furthermore, compound 11 was able to detect Tau aggregates in tauopathy brain sections from corticobasal degeneration, progressive supranuclear palsy, and Pick’s disease donors. Thus, 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c’]dipyridine (PI-2014, compound 11) was selected for characterization in a first-in-human study. In addition to this study using 2-(Piperidin-4-yl)ethanol, there are many other studies that have used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Formula: C7H15NO) was used in this study.

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKFormula: C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Zhang, Zhe; Zhang, Zhao-Sheng; Wang, Xiao; Xi, Gao-Lei; Jin, Zhen; Tang, You-Zhi published an article in 2021. The article was titled 《A click chemistry approach to pleuromutilin derivatives, evaluation of anti-MRSA activity and elucidation of binding mode by surface plasmon resonance and molecular docking》, and you may find the article in Journal of Enzyme Inhibition and Medicinal Chemistry.Related Products of 622-26-4 The information in the text is summarized as follows:

A series of pleuromutilin analogs containing substituted 1,2,3-triazole moieties I [R1 = Me, Ph, 3-fluorophenyl, etc.] and II [R2 = R3 = Me, cyclohexyl, etc.] were designed, synthesized and assessed for their in vitro antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA). Initially, the in vitro antibacterial activities of these derivatives against 4 strains of S. aureus (MRSA ATCC 43300, ATCC 29213, AD3, and 144) were tested by the broth dilution method. Most of the synthesized pleuromutilin analogs displayed potent activities. Among them, compounds I [R1 = 2-methylphenyl, 2-nitrophenyl, 4-nitrophenyl] (MIC = 0.5∼1 μg/mL) showed the most effective antibacterial activity and their anti-MRSA activity were further studied by the time-killing kinetics approach. Binding mode investigations by surface plasmon resonance (SPR) with 50S ribosome revealed that the selected compounds all showed obvious affinity for 50S ribosome (KD = 2.32 x 10-8∼5.10 x 10-5 M). Subsequently, the binding of compounds I [R1 = 2-methylphenyl, 4-nitrophenyl] to the 50S ribosome was further investigated by mol. modeling. Compound I [R1 = 2-methylphenyl] had a superior docking mode with 50S ribosome, and the binding free energy of compound was calculated to be -12.0 kcal/mol. In the experiment, the researchers used many compounds, for example, 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Related Products of 622-26-4)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKRelated Products of 622-26-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2016,Babu, J. Sree Ram; Sankar, T. Ravi; Babu, K. Sudhakar; Latha, J. published 《Synthesis, characterization and biological evaluation of some novel disubstituted heterocyclic derivatives》.Journal of Chemical and Pharmaceutical Research published the findings.SDS of cas: 622-26-4 The information in the text is summarized as follows:

Synthesis of some novel di-substituted 1-piperidin-4-yl(3,4-dibromphenyl)-1,3-dihydro-2H-benzimidazol-2-one derivatives (6A-6D) were prepared from com. available 1,2-henylenediamine. Compounds (6A-6D) were tested for Gram pos.: Streptococcus pyogenes and Staphylococcus aureus. Gram neg.: Escherichia coli, Pseudomonas arzenous, Proteus vulgaris, Salmonella typhi bacterial cultures. Compounds 6A-6D were found to be highly active against Streptococcus pyogenes and Escherichia coli. In the experiment, the researchers used many compounds, for example, 2-(Piperidin-4-yl)ethanol(cas: 622-26-4SDS of cas: 622-26-4)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.SDS of cas: 622-26-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2014,Sree Ram Babu, J.; Ravi Sankar, T.; Sudhakar Babu, K.; Latha, J. published 《Synthesis, characterization and biological evaluation of some novel disubstituted heterocyclic derivatives》.Journal of Chemical and Pharmaceutical Research published the findings.Computed Properties of C7H15NO The information in the text is summarized as follows:

Synthesis of disubstituted heterocyclic derivatives I [X = 3,4-(Cl)2; R = piperidin-1-yl, 4-hydroxypiperidin-1-yl, piperidin-4-ylmethanol, 2-(piperidin-4-yl)ethan-1-ol] were prepared from com. available 1,2-henylenediamine. The compounds I were tested for Gram pos.: Streptococcus pyogenes and Staphylococcus aureus. Gram neg.: Escherichia coli, Pseudomonas arzenous, Proteus vulgaris, Salmonella typhi bacterial cultures. The compounds I were found to be highly active against Streptococcus pyogenes and Escherichia coli.2-(Piperidin-4-yl)ethanol(cas: 622-26-4Computed Properties of C7H15NO) was used in this study.

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Computed Properties of C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2013,Sudhakar Babu, K.; Ravi Sankar, T.; Latha, J.; Ram Babu, B.; SwarnaKumari, M. published 《Synthesis and antibacterial activity of some novel 1-piperidin-4-yl-1,3-dihydro-2H-benzimidazol-2-one analogs》.Journal of Applicable Chemistry (Lumami, India) published the findings.Application In Synthesis of 2-(Piperidin-4-yl)ethanol The information in the text is summarized as follows:

Synthesis of some novel 1-piperidin-4-yl-1,3-dihydro-2H-benzimidazol-2-one derivatives were prepared from com. available 1,2-phenylenediamine. These compounds were tested for their antibacterial activity against gram pos. Streptococcus pyogenes and Staphylococcus aureus and against gram neg. Escherichia coli, Pseudomonas arsenous, Proteus vulgaris, Salmonella typhii bacterial cultures. The title compounds were highly active against Streptococcus pyogenes and Escherichia coli. In addition to this study using 2-(Piperidin-4-yl)ethanol, there are many other studies that have used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Application In Synthesis of 2-(Piperidin-4-yl)ethanol) was used in this study.

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKApplication In Synthesis of 2-(Piperidin-4-yl)ethanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2014,Vidadala, Rama Subba Rao; Ojo, Kayode K.; Johnson, Steven M.; Zhang, Zhongsheng; Leonard, Stephen E.; Mitra, Arinjay; Choi, Ryan; Reid, Molly C.; Keyloun, Katelyn R.; Fox, Anna M. W.; Kennedy, Mark; Silver-Brace, Tiffany; Hume, Jen C. C.; Kappe, Stefan; Verlinde, Christophe L. M. J.; Fan, Erkang; Merritt, Ethan A.; Van Voorhis, Wesley C.; Maly, Dustin J. published 《Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes》.European Journal of Medicinal Chemistry published the findings.Synthetic Route of C7H15NO The information in the text is summarized as follows:

Malaria remains a major health concern for a large percentage of the world’s population. While great strides have been made in reducing mortality due to malaria, new strategies and therapies are still needed. Therapies that are capable of blocking the transmission of Plasmodium parasites are particularly attractive, but only primaquine accomplishes this, and toxicity issues hamper its widespread use. In this study, the authors describe a series of pyrazolopyrimidine- and imidazopyrazine-based compounds that are potent inhibitors of PfCDPK4, which is a calcium-activated Plasmodium protein kinase that is essential for exflagellation of male gametocytes. Thus, PfCDPK4 is essential for the sexual development of Plasmodium parasites and their ability to infect mosquitoes. The authors demonstrate that two structural features in the ATP-binding site of PfCDPK4 can be exploited to obtain potent and selective inhibitors of this enzyme. Furthermore, the authors demonstrate that pyrazolopyrimidine-based inhibitors that are potent inhibitors of the in vitro activity of PfCDPK4 are also able to block Plasmodium falciparum exflagellation with no observable toxicity to human cells. This medicinal chem. effort serves as a valuable starting point in the development of safe, transmission-blocking agents for the control of malaria. In the experiment, the researchers used many compounds, for example, 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Synthetic Route of C7H15NO)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKSynthetic Route of C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《A simple, robust and efficient structural model to predict CO2 absorption for different amine solutions: Concern to design new amine compounds》 was published in Journal of Environmental Chemical Engineering in 2020. These research results belong to Raznahan, Mohammad Moein; Riahi, Siavash; Mousavi, Seyed Hamed. Application In Synthesis of 2-(Piperidin-4-yl)ethanol The article mentions the following:

The absorption capacity (AC) and absorption rate (AR) are considered as the two main characteristics in choosing the great amine solutions for carbon dioxide absorption. However, selecting the proper amine-based solution on a vast number of exptl. procedures is unaffordable regarding cost and time. Accordingly, studying and modeling amine structures and discovering the relationship between structural parameters and the AC and AR values of amine compounds are of great necessity. The Quant. Structure-Property Relationship (QSPR) method, which is considered as an efficient procedure, is used for predicting carbon dioxide absorption by amine solutions The present study was performed on two different groups of amine solutions, including chained and non-ring-shaped structures for group 1 and major ring-shaped structures for group 2. Then, linear and nonlinear models were applied to create QSPR models, resp. The values of the square of the correlation coefficient (R2) for linear and nonlinear models were 0.753 and 0.985, as well as 0.895 and 0.954 for groups 1 and 2, resp. The results demonstrated that applying a nonlinear model is more efficient and accurate than the linear model for predicting absorption. Further, the prediction of the CO2 absorption value is achievable with high precision for groups 1 and 2 using only 1 and 2 descriptors, resp. In this paper, new amine mols. were designed based on their primary structures and the reported descriptor. Finally, the constructed compounds were found to have better AR and AC compared to initial structures. In the experimental materials used by the author, we found 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Application In Synthesis of 2-(Piperidin-4-yl)ethanol)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Application In Synthesis of 2-(Piperidin-4-yl)ethanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2019,Proceedings of the National Academy of Sciences of the United States of America included an article by Hong, W. David; Benayoud, Farid; Nixon, Gemma L.; Ford, Louise; Johnston, Kelly L.; Clare, Rachel H.; Cassidy, Andrew; Cook, Darren A. N.; Siu, Amy; Shiotani, Motohiro; Webborn, Peter J. H.; Kavanagh, Stefan; Aljayyoussi, Ghaith; Murphy, Emma; Steven, Andrew; Archer, John; Struever, Dominique; Frohberger, Stefan J.; Ehrens, Alexandra; Hubner, Marc P.; Hoerauf, Achim; Roberts, Adam P.; Hubbard, Alasdair T. M.; Tate, Edward W.; Serwa, Remigiusz A.; Leung, Suet C.; Qie, Li; Berry, Neil G.; Gusovsky, Fabian; Hemingway, Janet; Turner, Joseph D.; Taylor, Mark J.; Ward, Stephen A.; O’Neill, Paul M.. Electric Literature of C7H15NO. The article was titled 《AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis》. The information in the text is summarized as follows:

Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼ 157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the lack of a safe drug that can kill the adult filaria (macrofilaricide). Previous proof-of-concept human trials have demonstrated that depleting > 90% of the essential nematode endosymbiont bacterium, Wolbachia, using antibiotics, can lead to permanent sterilization of adult female parasites and a safe macrofilaricidal outcome. AWZ1066S is a highly specific anti-Wolbachia candidate selected through a lead optimization program focused on balancing efficacy, safety and drug metabolism/pharmacokinetic (DMPK) features of a thienopyrimidine/quinazoline scaffold derived from phenotypic screening. AWZ1066S shows superior efficacy to existing anti-Wolbachia therapies in validated preclin. models of infection and has DMPK characteristics that are compatible with a short therapeutic regimen of 7 days or less. This candidate mol. is well-positioned for onward development and has the potential to make a significant impact on communities affected by filariasis. The experimental process involved the reaction of 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Electric Literature of C7H15NO)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Electric Literature of C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem