Category: 622-26-4

New learning discoveries about 2-(Piperidin-4-yl)ethanol

Electric Literature of 622-26-4, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 622-26-4.

Electric Literature of 622-26-4, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 622-26-4, Name is 2-(Piperidin-4-yl)ethanol, SMILES is OCCC1CCNCC1, belongs to piperidines compound. In a article, author is Mohamadpour, Farzaneh, introduce new discover of the category.

Malonic Acid as A Green and Efficient Catalyst for the Mass-scale Synthesis of Pyrrole Medicinal Drugs

A green and naturally biodegradable malonic acid synthesis of highly substituted dihydro-2-oxopyrrole derivatives has been accomplished via one-pot four-condensation of amines (aromatic or aliphatic), dialkyl acetylenedicarboxylate, and formaldehyde under mild reaction conditions. The notable advantages of the present procedure are a green, low cost, and efficient catalyst; operational simplicity; no need for chromatographic purification steps; short reaction times; and good to high yields.

Electric Literature of 622-26-4, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 622-26-4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Analyzing the synthesis route of 622-26-4

622-26-4 2-(Piperidin-4-yl)ethanol 73953, apiperidines compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.622-26-4,2-(Piperidin-4-yl)ethanol,as a common compound, the synthetic route is as follows.

2-(Piperidin-4-yl)ethan-1-ol (3.00 g, 23.22 mmol) was dissolved in 30 mL dichloromethane. Di-tert-butyl dicarbonate (5.22 g, 23.92 mmol) was slowly added portionwise at 15 to 20 C. After that, the reaction mixture was stirred for 20 h at room temperature. The reaction mixture was slowly poured into 50 mL water after the reaction was complete as monitored by TLC. Then, the mixture was extracted with dichloromethane (50 mL¡Á2). The combined organic layer was dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under vacuum to give a residue. The residue was purified by column chromatography (Height: 250 mm, Diameter, 20 mm, 100-200 slica gel, petroleum/ethyl acetate=3:1, 1:1) to afford 2-(1-tert-butoxycarbonyl-4-piperidyl)ethanol (4.89 g, 91.83% yield) as a colorless liquid.

622-26-4 2-(Piperidin-4-yl)ethanol 73953, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; MEDSHINE DISCOVERY INC.; DING, Charles Z.; SUN, Fei; WU, Lifang; DU, Jinhua; KATSU, Yasuhiro; HU, Guoping; LI, Jian; (46 pag.)US2018/148452; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem