60407-35-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.60407-35-4,1-Benzylpiperidin-3-amine,as a common compound, the synthetic route is as follows.
A mbdure of sodium (E-3-(1 (3-1dimethylamino,?propyl)-2-methyl-1H-indoI-3-yt)acrylate(200 mg, 0.65 mmol), i-benzylpiperidin-3-amine (104 mg, 0.65 mmol), EDCI (248 mg,1 35 mmol), HOBt (88 mg, 0 65 mmol) and TEA (136 mg, 1 35 rnrnol) in DCM (15 mL)was stirred at room temperature overnight. The reaction mixture was washed with saturated Na2CO3, dried over Na2SO4 and concentrated. The crude product was purified by preparative TLC to give a solid (63 mg, 21 %).1H NMR (400 MHz.. CDCI3): 5 7.96-7.92 (m, 2H), 7.40-7.25 (m, 8H), 7.46 (d, J =15.6 Hz, IH), 4.34 (br s, 1H), 4.23 (1, J = 7.2 Hz, 2H), 3.63 (br s, 2H), 276-2.60 (rn,3H) 2 58 (s, 3H) 2 41-2 32 (m 9H) 2 04-1 97 ,m 2H) 1 90-1 62 (m, 4H) LCMS ma459.1 [M+H]
60407-35-4 1-Benzylpiperidin-3-amine 12275357, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; NOVOGEN LTD; JAMES, Ian; DIXON, Ian; BU, Xian; WO2015/74124; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem