Category: 600-05-5

Related Products of 600-05-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2,3-Dibromopropionic acid, is researched, Molecular C3H4Br2O2, CAS is 600-05-5, about Bifunctional catalysts. V. Reconjugation of Δ5-cholestenone. Author is Kergomard, A.; Renard, M. F..

Dihaloacetic and -propionic acids catalyze the reconjugation of cholest-5-en-3-one (I). The reconjugation of I is also catalyzed by mixtures of triethylamine and phenols. The acid catalysis involves 2 mols. acid/mol. I, and the distance between the active sites (carbonyl O and C-5) is 5 Å. The enthalpy and entropy of activation are 11 ± 2 kcal/mole and -38 ± 4esu for I in benzene containing trichloroacetic acid.

《Bifunctional catalysts. V. Reconjugation of Δ5-cholestenone》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,3-Dibromopropionic acid)Related Products of 600-05-5.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Delsuc, Marc A.; Levy, George C. published an article about the compound: 2,3-Dibromopropionic acid( cas:600-05-5,SMILESS:O=C(O)C(Br)CBr ).Quality Control of 2,3-Dibromopropionic acid. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:600-05-5) through the article.

The deconvolution of J-coupling patterns in NMR by iterative maximum entropy processing is demonstrated. Both the in-phase and the antiphase coupling patterns are considered. The deconvolution of the coupling pattern, either for one value of the coupling constant or for a range of coupling constants is shown. The method can be used for improving the signal-to-noise ratio for known coupling patterns by removing the coupling structure, as well as for extracting coupling constants from an unknown spectrum. Examples are shown both in ID (dimensional) NMR and in slicewise processing of 2D spectra.

《The application of maximum entropy processing to the deconvolution of coupling patterns in NMR》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,3-Dibromopropionic acid)Quality Control of 2,3-Dibromopropionic acid.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Vinyl polymers. X. Polymers of the α-haloacrylic acids and their derivatives》. Authors are Marvel, C. S.; Dec, Joseph; Cooke, H. G. Jr.; Cowan, John Charles.The article about the compound:2,3-Dibromopropionic acidcas:600-05-5,SMILESS:O=C(O)C(Br)CBr).HPLC of Formula: 600-05-5. Through the article, more information about this compound (cas:600-05-5) is conveyed.

cf. C. A. 34, 7863.8. Passing Cl into a mixture of 2265 g. tech. Me acrylate and 1 l. MeOH at a temperature below 40° for 5-6 h. gives 85% of the Me ester (I) of III, b21 72-5°; Br gives 85-8% of the Me ester (II) of IV, b22 96-8°. Refluxing 175 g. of I and 500 cc. 20% HCl for 5 h. and extracting with 3 100-cc. portions of CHCl3 give a 65% yield of crude ClCH2CHClCO2H (III); II gives 72% of BrCH2CHBrCO2H (IV) on hydrolysis with 48% HBr. With SOCl2 III gives 53% of the acid chloride (V), b16 52-4°, and IV gives 77% of the acid chloride (VI), b18 81-4°. With excess of the proper alc. (heating at 100° for 10 min.) V gives the following esters of III: sec-Bu, b25 65-6°, nD20 1.4423, d2020 1.150, 88%; cyclohexyl, b2 95-7°, nD20 1.4752, 91%; β-chloroethyl, b22 123-6°, nD20 1.4739. VI gives the esters of IV: sec-Bu, b26 130-5°, nD20 1.4855, d2020 130-2°, 89%; cyclohexyl, b2 130-2°, nD20 1.5139, 93%. PhOH and C5H5N with V yield 41% of the Ph ester of III, b18 130-5°, nD20 1.5262; VI gives 45.5% of the Ph ester of IV, b2 132-5°, nD20 1.5598. The α-haloacrylates were prepared by heating about 0.07 mol of the above esters and 0.10 mol of quinoline, quinaldine or PhNEt2 at 100° for 10 min. in a N atm. α-Chloroacrylic esters: Et, b18 51-3°, nD20 1.4384, 81%; sec-Bu, b23 73-3.5°, nD20 1.4360, 58%; cyclohexyl, b2 51-2°, nD20 1.4735, 69%; Ph, b8 91-3°, nD20 1.5808, 25%; β-chloroethyl, b20 94-6°, nD20 1.4729, 45%. α-Bromoacrylic esters: sec-Bu, b23 80-2°, nD20 1.4660, d2020 1.303, 72%; cyclohexyl, b4 100-6°, nD20 1.4954, 54%; Ph, b2 95-6°, nD20 1.5480, 46%. These esters polymerize on standing at room temperature for 2-3 wk, on heating at 100° for 20-30 min., by the action of UV light for 6-8 h., in the presence of Bz2O2, etc. In bulk polymerization experiments clear, hard glassy products were obtained; the polymers precipitated from dioxane by ether or alc. are white powders. Poly-α-chloroacrylic esters: Et, decomposes 160-70°, n25 1.502; sec-Bu, decomposes 160-5°, n25 1.500; cyclohexyl, decomposes 210-35°, n25 1.532; Ph, decomposes 160-8°; β-chloroethyl, decomposes 230-40°, n25 1.533. α-Br derivatives: Et, decomposes 125-30°; sec-Bu, decomposes 150-60°, n25 1.542; cyclohexyl, decomposes 140-50°, n25 1.547; Ph, decomposes 175-85°, n25 1.612. CH2:CClCO2H (VII) results in 62% yield by adding dropwise 110 g. of I to 275 g. Ba(OH)2.8H2O and 500 cc. H2O, stirring 2 h. and adding 62.5 g. concentrated H2SO4 in 125 cc. H2O, extracting with 5 200-cc. portions of ether containing hydroquinone and crystallizing from petr. ether. CH2:CBrCO2H (VIII) similarly results in 70% yield from II. Illumination of 75 g. VII in 500 cc. anhydrous ether for 3 days gives 55 g. of the polymer (IX), m. about 300°; it is soluble in cold H2O and forms clear, tough films. Addition of 0.1 g. Bz2O2 to 10 g. VII at 70° causes polymerization in 15 min. (5.5 g. of IX); boiling 10 g. IX with 50 cc. H2O gives a gel, hardening to an easily pulverizable mass, which analyzes for C3H2O2; it is apparently a cross-linked lactone with some HO groups. Dropwise addition of 25 g. of ClCH2CHClCOCl to 25 g. of PhNEt2 at 85° and 70-80 mm. gives 37% of the chloride, of VII, b78 45-8°, nD20 1.4689; illumination in CCl4 for 3 days gives 67% of the polymer, m. 210-25°; the film from 1 g. in 10 cc. H2O resembles that of IX. The polymer of VIII is relatively unstable and loses HBr rapidly at room temperature ClCH2CH2COCl (50 g.) and 35 g. HOC2H4Cl give 62 g. (92%) of β-chloroethyl β-chloropropionate, b20 109-11°, nD20 1.4600; treatment with quinoline at 150-60° for 20 min. gives 53% of β-chloroethyl acrylate, b20 64-6°, nD20 1.4490; the polymer is a soft rubbery material which did not harden on longer illumination.

《Vinyl polymers. X. Polymers of the α-haloacrylic acids and their derivatives》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,3-Dibromopropionic acid)HPLC of Formula: 600-05-5.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The effects of groups on the reaction rate. Reaction of α,β-dibromides with sodium iodide》. Authors are Davis, Tenney L.; Heggie, Robert.The article about the compound:2,3-Dibromopropionic acidcas:600-05-5,SMILESS:O=C(O)C(Br)CBr).Recommanded Product: 600-05-5. Through the article, more information about this compound (cas:600-05-5) is conveyed.

The rates of reaction at several temperatures of NaI in alc. with the dibromides of certain unsaturated aliphatic compounds and in Me2CO with the dibromides of substituted chalcones were measured. Good 2nd-order constants were obtained in all cases except those involving MeCHBrCH2Br and PrCHBrCH2Br. Constants of the 1st order were also unsatisfactory for these cases. The reaction of α,β-dibromopropionic acid with NaI was much faster in Me2CO than in alc. In the aliphatic series compounds containing electron-attracting groups reacted much faster than those containing groups which tend to supply electrons. Substituted chalcone dibromides reacted more rapidly than simple chalcone dibromide. The energy of activation, E, was calculated for several reactions and the probability factors were calculated from the equation, K = PZe-E/RT. The Me, Pr and CH2OH groups increased E; the CO2Et and CO2H groups decreased E; 2 CO2H groups had more effect than one; the effect of one CO2H was greater than the opposing effect of a Me group. A CO2H group reduced P; a 2nd CO2H group increased P, but not to the value possessed by the compound containing H instead of CO2H.

Different reactions of this compound(2,3-Dibromopropionic acid)Recommanded Product: 600-05-5 require different conditions, so the reaction conditions are very important.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Determination of the relative signs of proton-proton spin a coupling constants》. Authors are McLauchlan, K. A..The article about the compound:2,3-Dibromopropionic acidcas:600-05-5,SMILESS:O=C(O)C(Br)CBr).Electric Literature of C3H4Br2O2. Through the article, more information about this compound (cas:600-05-5) is conveyed.

cf. CA 57, 306d, 13322d. Three different methods, accurate analysis, double irradiation, and doublequantum spectra, by which the relative signs of proton-proton spin coupling constants can be determined, are discussed. In particular, each is applied to the 1,2-dibromopropionic acid mol. which contains geminate and vicinal couplings of opposite sign. The double-quantum spectrum gave the relative signs in a particularly simple manner.

The article 《Determination of the relative signs of proton-proton spin a coupling constants》 also mentions many details about this compound(600-05-5)Electric Literature of C3H4Br2O2, you can pay attention to it, because details determine success or failure

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 600-05-5, is researched, Molecular C3H4Br2O2, about Mutagenic activation of tris(2,3-dibromopropyl)phosphate: the role of microsomal oxidative metabolism, the main research direction is Salmonella mutation tris dibromopropylphosphate; mutagen metabolic activation flame retardant.Related Products of 600-05-5.

The flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) [126-72-7] was converted to products which were mutagenic for Salmonella typhimurium TA 100 in the presence of rat liver microsomes, NADPH, and O. Other bromopropyl compounds were also mutagenic; 2,3-dibromopropene [513-31-5] and 2,3-dibromopropionic acid [600-05-5] were directly mutagenic, whereas 2,3-dibromopropanol [96-13-9] and tris(2-bromopropyl)phosphate [31858-09-0] were weakly mutagenic after addition of liver microsomes and cofactors. Typical in vivo and in vitro inhibitors of cytochrome P-450 inhibited Tris-BP mutagenicity. The effects of inducers of cytochrome P-450 on Tris-BP mutagenicity was dependent on the concentration of mutagen and microsomal protein in the assay, indicating complexity in the kinetics involved when dealing with possible multiple paths that lead to mutagenicity. Addition of glutathione strongly inhibited Tris-BP mutagenicity. Tris-BP may be oxidized to a reactive electrophile, possibly the 2-keto derivative, which could react with nucleophilic groups in DNA and thus lead to mutagenic events.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 600-05-5, is researched, SMILESS is O=C(O)C(Br)CBr, Molecular C3H4Br2O2Journal, Pramana called Quantum entanglement in the NMR implementation of the Deutsch-Jozsa algorithm, Author is Arvind; Dorai, Kavita; Kumar, Anil, the main research direction is quantum entanglement NMR implementation Deutsch Jozsa algorithm; computing quantum NMR bromopropionic acid.Recommanded Product: 600-05-5.

A scheme to execute an n-bit Deutsch-Jozsa (DJ) algorithm using n qubits was implemented for up to three qubits on an NMR quantum computer. For the 1- and the two-bit Deutsch problem, the qubits do not get entangled, and the NMR implementation is achieved without using spin-spin interactions. It is for the three-bit case, that the manipulation of entangled states becomes essential. The interactions through scalar J-couplings in NMR spin systems were exploited to implement entangling transformations required for the three bit DJ algorithm.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Preparation of esters of acrylic acid》. Authors are Kobeko, P. P.; Koton, M. M.; Florinskii, F. S..The article about the compound:2,3-Dibromopropionic acidcas:600-05-5,SMILESS:O=C(O)C(Br)CBr).Application In Synthesis of 2,3-Dibromopropionic acid. Through the article, more information about this compound (cas:600-05-5) is conveyed.

KHSO4 200, anhydrous Na2SO4 40 g. and dry glycerol 129 cc. were heated in a 1-l. Cu flask, provided with a condenser for removal of acrolein and a dropping funnel for addition of glycerol, until acrolein appeared in the condenser; then 500 cc. more dry glycerol was added by drops for 5-6 hrs. at 200°. To the acrolein obtained was added Br in ether by drops for 3 hrs., while the reaction mixture was cooled; the product was heated on a water bath. The CH2BrCHBrCHO was oxidized with HNO3 (d. 1.41) while cooling in ice-NaCl mixture The liquid was evaporated, the product was filtered out, washed with cold HNO3 (d. 1.41) and heated in a water bath to remove the residue of HNO3. The CH2BrCHBrCO2H was esterified with EtOH, BuOH, and iso-AmOH, resp., in the presence of HCl. Et ester, b. 211-14°; Bu ester, b4 105°, b12 135-7°; iso-Am ester b2 110-12°, b12 125-30°. The esters were debrominated by adding their emulsions (100 cc. of ester and 20 cc. of 20% H2SO4) by drops to EtOH and Zn shavings and heating at 78-80° for 4 hrs. The product after removal of the solids was washed with ether and with water, and then was treated in the usual way. The yield of acrylic esters was 75.8%: Et, b. 98-9°, b12 49° d20 0.9125; Bu, b. 128-30°, b12 66-8°, d20 0.9141; iso-Am, b. 149-51°, b12 73-5°, d20 0.9160. The esters were polymerized at high temperature and on standing in the presence of light at room temperature

The article 《Preparation of esters of acrylic acid》 also mentions many details about this compound(600-05-5)Application In Synthesis of 2,3-Dibromopropionic acid, you can pay attention to it, because details determine success or failure

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

SDS of cas: 600-05-5. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,3-Dibromopropionic acid, is researched, Molecular C3H4Br2O2, CAS is 600-05-5, about Phase-sensitive two-dimensional HMQC and HMQC-TOCSY spectra obtained using double pulsed-field-gradient spin echoes. Author is Mackin, Gilbert; Shaka, A. J..

A new and promising method for recording phase-sensitive HMQC and HMQC-TOCSY spectra of mols. with natural-abundance C-13 isotopes is described. It avoids phase modulation of the NMR signals obtained with conventional coherence-transfer pathway selection using pulsed field gradients and results in an improvement in sensitivity. The spectra can be processed according to standard States-Haberkorn-Ruben methods, making the incorporation of gradients transparent to routine users. Strong unwanted proton signals from the C-12 isotopomers are attenuated by a double-gradient BIRD pulse at the beginning of the pulse sequences, resulting in high-quality spectra. By incorporating carefully designed purging sequences, high-resolution proton multiplets were obtained.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2,3-Dibromopropionic acid, is researched, Molecular C3H4Br2O2, CAS is 600-05-5, about Fourier transform double-resonance NMR on two- and three-spin systems, the main research direction is NMR Fourier transform strong coupling.Reference of 2,3-Dibromopropionic acid.

The flip angle dependence of the line intensities in gated double-resonance FT NMR experiments on the stongly coupled spin systems 2,3-dibromothiophene, 1,2,3-trichlorobenzene, vinyl acetate, and 2,3-dibromopropionic acid follow the theory of S. Shaublin, A. Hohener, and R. R. Ernest (1974). A general method for anal. of the flip-angle-dependent intensities in terms of spin level population differences is described, and it is demonstrated that the variation of line intensities with flip angle is sensitive to the relative signs of spin-spin couplings and to the mechanism of spin relaxation.

After consulting a lot of data, we found that this compound(600-05-5)Reference of 2,3-Dibromopropionic acid can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem