5984-56-5,5984-56-5, Piperidine-4-carboxylic acid hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of piperidine-4-carboxylic acid hydrochloride (500 mg, 2.26 mmol) and triethylamine (2.29 g, 22.6 mmol) in 1,2-dichloroethane (50 mL) was added methyl2-(chlorosulfonyl)acetate (1.17 g, 6.78 mmol) at 0 C under nitrogen atmosphere. After stirred at 0 C for 4 hours, the mixture was poured into water (40 mL) and extracted with dichloromethane (50 mL) for three times. The combined organic layers were washed with brine (100 mL) twice, dried over Na2SO4(), filtered and concentrated under reduced pressure to give a residue, which was purified by silica gel columnchromatography (petroleum ether: ethyl acetate = 9 : ito 3 : 1) to give the title compound (475 mg, 65 % yield) as yellow solids. ?H NIVII{ (400 1VIHz, CDC13) 3.92 (s, 2H), 3.79 (s, 3H), 3.75 – 3.70 (m, 2H), 3.04 – 2.98 (m, 2H), 2.39 – 2.32 (m, 1H), 1.98 -1.92 (m, 2H), 1.81 – 1.71 (m, 2H), 1.44 (s, 9H).
The synthetic route of 5984-56-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; JOHNSON & JOHNSON (CHINA) INVESTMENT LTD.; WAN, Zhao-Kui; JIANG, Yimin; DAI, Xuedong; LIU, Qian; CHEUNG, Wing Shun; DENG, Gang; FU, Liqiang; (547 pag.)WO2019/1420; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem