Category: 59234-40-1

Mitsakos, Voula; Dobson, Renwick C. J.; Pearce, F. Grant; Devenish, Sean R.; Evans, Genevieve L.; Burgess, Benjamin R.; Perugini, Matthew A.; Gerrard, Juliet A.; Hutton, Craig A. published an article on January 15 ,2008. The article was titled 《Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Synthetic Route of C7H11NO4 The information in the text is summarized as follows:

Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and an important antibiotic target. The specificity of a range of heterocyclic product analogs against DHDPS from three pathogenic species, Bacillus anthracis, Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, and the evolutionarily related N-acetylneuraminate lyase, has been determined The results suggest that the development of species-specific inhibitors of DHDPS as potential antibacterials is achievable. In the experiment, the researchers used many compounds, for example, Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1Synthetic Route of C7H11NO4)

Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Synthetic Route of C7H11NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

COA of Formula: C7H11NO4On September 15, 1993 ,《Characterization of [35S]lanthionine ketimine specific binding to bovine brain membranes》 was published in Biochemical and Biophysical Research Communications. The article was written by Dupre, S.; Fontana, M.; Costa, M.; Pecci, L.; Ricci, G.; Cavallini, D.. The article contains the following contents:

[35S]Lanthionine ketimine binds specifically and with high affinity to bovine brain membranes. This binding has been studied in detail. It is reversible, not occurring at an uptake site or at a metabolizing enzyme and depending only weakly on ionic strength; it is affected by thiol reagents. [35S]Lanthionine ketimine specific binding is displaced only by other ketimines and by catecholamines, but not by more selective adrenergic ligands; binding parameters are reported. [3H]Adrenaline but not [3H]dihydroalprenolol is partially displaced by lanthionine ketimine. With bovine brain preparations a significant stimulation of basal adenylate cyclase activity by lanthionine ketimine is observedCis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1COA of Formula: C7H11NO4) was used in this study.

Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.COA of Formula: C7H11NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ohtani, Bunsho; Kusakabe, Satoshi; Okada, Katsumi; Tsuru, Shigeto; Nishimoto, Sei-ichi; Amino, Yusuke; Izawa, Kunisuke; Nakato, Yoshihiro; Matsumura, Michio; Nakaoka, Yasuhiro; Nosaka, Yoshio published their research in Journal of the Chemical Society, Perkin Transactions 2 on February 28 ,2001. The article was titled 《Photocatalytic stereoselective N-cyclization of 2,6-diaminopimelic acid into piperidine-2,6-dicarboxylic acid by an aqueous suspension of activated cadmium(II) sulfide particles》.Electric Literature of C7H11NO4 The article contains the following contents:

Photoirradiation at a wavelength of >300 nm of a deaerated suspension of cadmium(II) sulfide (CdS) particles in an aqueous solution of a mixture of stereoisomers of 2,6-diaminopimelic acid [DAP; (S,S):(R,S):(R,R) = 1:2:1] produced piperidine-2,6-dicarboxylic acid (PDC) via a redox-combined mechanism including oxidation and reduction by pos. holes and photoexcited electrons, resp. Both the yield and trans:cis ratio of PDC markedly depended on the kinds of CdS photocatalysts, their pre-treatment, and the loading of fine platinum (or its oxide) particles. A CdS photocatalyst prepared by heat treatment of a com. powder in hexagonal (wurtzite) structure at 1023 K in the presence of a small amount of air gave the highest yield and trans:cis ratio. Analyses of the activated CdS powder by powder x-ray diffraction (XRD), photoluminescence (PL), XPS, ESR, and BET surface area measurements revealed the formation of sulfur vacancies due to heat treatment, which promote the photoinduced cadmium metal (Cd0) deposition. The Cd0, deposited in situ on the CdS surface and detected by reduction of methylviologen, may act as a reduction site for photoexcited electrons toward a cyclic Schiff base intermediate produced by oxidation of DAP with pos. holes followed by deamination and intramol. condensation. Optically pure (R,R)- or (S,S)-PDCs were prepared successfully by photocatalytic reaction with the activated CdS particles using (R,R)- or (S,S)-DAPs, indicating that stereoselective conversion of organic compounds can be achieved via photocatalytic reaction under controlled conditions. The results came from multiple reactions, including the reaction of Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1Electric Literature of C7H11NO4)

Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Electric Literature of C7H11NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Safety of Cis-piperidine-2,6-dicarboxylic acidOn October 31, 1982 ,《The excitatory actions of a series of piperidine dicarboxylates on central neurons of the rat, snail, leech, and horseshoe crab and on crab neuromuscular junction》 was published in Comparative Biochemistry and Physiology, C: Comparative Pharmacology. The article was written by King, D. J.; McBain, Anne E.; Jais, M. Mat; Roberts, C. Jane; Collins, J. F.; Wheal, H. V.; Walker, R. J.. The article contains the following contents:

The 2,3- [46026-75-9], 2,4- [84211-45-0], 2,5- [84619-48-7], and 2,6-piperidine dicarboxylates [59234-40-1] were devoid of direct or indirect effects of the Helix neuron; the 2,5-analog mimicked the actions of L-glutamate (I) [56-86-0] on Limulus neurons, and these were inhibited by I. All 4 piperidines mimicked the actions of I on Hirudo and rat neurons and Eupagurus muscle. All were weak agonists on rat neurons, whereas on Hirudo neurons the 2,5-analog was the most potent; on the Eupagurus muscle the 2,3- and 2,6-analogs were the most potent. All 4 piperidines potentiated the action of I on rat and Hirudo neurons and on Eupagurus leg muscle and of muscle excitatory junction potentials. Thus, there are probably differences between I receptors used in the study, and the preferred conformation for I on crab leg muscle may be the partially folded one and that for Hirudo neurons is more extended. The experimental part of the paper was very detailed, including the reaction process of Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1Safety of Cis-piperidine-2,6-dicarboxylic acid)

Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Safety of Cis-piperidine-2,6-dicarboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Mitsakos, Voula; Dobson, Renwick C. J.; Pearce, F. Grant; Devenish, Sean R.; Evans, Genevieve L.; Burgess, Benjamin R.; Perugini, Matthew A.; Gerrard, Juliet A.; Hutton, Craig A. published an article on January 15 ,2008. The article was titled 《Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Name: Cis-piperidine-2,6-dicarboxylic acid The information in the text is summarized as follows:

Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and an important antibiotic target. The specificity of a range of heterocyclic product analogs against DHDPS from three pathogenic species, Bacillus anthracis, Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, and the evolutionarily related N-acetylneuraminate lyase, has been determined The results suggest that the development of species-specific inhibitors of DHDPS as potential antibacterials is achievable. In the experiment, the researchers used many compounds, for example, Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1Name: Cis-piperidine-2,6-dicarboxylic acid)

Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Name: Cis-piperidine-2,6-dicarboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

COA of Formula: C7H11NO4On September 15, 1993 ,《Characterization of [35S]lanthionine ketimine specific binding to bovine brain membranes》 was published in Biochemical and Biophysical Research Communications. The article was written by Dupre, S.; Fontana, M.; Costa, M.; Pecci, L.; Ricci, G.; Cavallini, D.. The article contains the following contents:

[35S]Lanthionine ketimine binds specifically and with high affinity to bovine brain membranes. This binding has been studied in detail. It is reversible, not occurring at an uptake site or at a metabolizing enzyme and depending only weakly on ionic strength; it is affected by thiol reagents. [35S]Lanthionine ketimine specific binding is displaced only by other ketimines and by catecholamines, but not by more selective adrenergic ligands; binding parameters are reported. [3H]Adrenaline but not [3H]dihydroalprenolol is partially displaced by lanthionine ketimine. With bovine brain preparations a significant stimulation of basal adenylate cyclase activity by lanthionine ketimine is observedCis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1COA of Formula: C7H11NO4) was used in this study.

Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.COA of Formula: C7H11NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Recommanded Product: 59234-40-1On October 31, 1982 ,《The excitatory actions of a series of piperidine dicarboxylates on central neurons of the rat, snail, leech, and horseshoe crab and on crab neuromuscular junction》 was published in Comparative Biochemistry and Physiology, C: Comparative Pharmacology. The article was written by King, D. J.; McBain, Anne E.; Jais, M. Mat; Roberts, C. Jane; Collins, J. F.; Wheal, H. V.; Walker, R. J.. The article contains the following contents:

The 2,3- [46026-75-9], 2,4- [84211-45-0], 2,5- [84619-48-7], and 2,6-piperidine dicarboxylates [59234-40-1] were devoid of direct or indirect effects of the Helix neuron; the 2,5-analog mimicked the actions of L-glutamate (I) [56-86-0] on Limulus neurons, and these were inhibited by I. All 4 piperidines mimicked the actions of I on Hirudo and rat neurons and Eupagurus muscle. All were weak agonists on rat neurons, whereas on Hirudo neurons the 2,5-analog was the most potent; on the Eupagurus muscle the 2,3- and 2,6-analogs were the most potent. All 4 piperidines potentiated the action of I on rat and Hirudo neurons and on Eupagurus leg muscle and of muscle excitatory junction potentials. Thus, there are probably differences between I receptors used in the study, and the preferred conformation for I on crab leg muscle may be the partially folded one and that for Hirudo neurons is more extended. The experimental part of the paper was very detailed, including the reaction process of Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1Recommanded Product: 59234-40-1)

Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Recommanded Product: 59234-40-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ohtani, Bunsho; Kusakabe, Satoshi; Okada, Katsumi; Tsuru, Shigeto; Nishimoto, Sei-ichi; Amino, Yusuke; Izawa, Kunisuke; Nakato, Yoshihiro; Matsumura, Michio; Nakaoka, Yasuhiro; Nosaka, Yoshio published their research in Journal of the Chemical Society, Perkin Transactions 2 on February 28 ,2001. The article was titled 《Photocatalytic stereoselective N-cyclization of 2,6-diaminopimelic acid into piperidine-2,6-dicarboxylic acid by an aqueous suspension of activated cadmium(II) sulfide particles》.Computed Properties of C7H11NO4 The article contains the following contents:

Photoirradiation at a wavelength of >300 nm of a deaerated suspension of cadmium(II) sulfide (CdS) particles in an aqueous solution of a mixture of stereoisomers of 2,6-diaminopimelic acid [DAP; (S,S):(R,S):(R,R) = 1:2:1] produced piperidine-2,6-dicarboxylic acid (PDC) via a redox-combined mechanism including oxidation and reduction by pos. holes and photoexcited electrons, resp. Both the yield and trans:cis ratio of PDC markedly depended on the kinds of CdS photocatalysts, their pre-treatment, and the loading of fine platinum (or its oxide) particles. A CdS photocatalyst prepared by heat treatment of a com. powder in hexagonal (wurtzite) structure at 1023 K in the presence of a small amount of air gave the highest yield and trans:cis ratio. Analyses of the activated CdS powder by powder x-ray diffraction (XRD), photoluminescence (PL), XPS, ESR, and BET surface area measurements revealed the formation of sulfur vacancies due to heat treatment, which promote the photoinduced cadmium metal (Cd0) deposition. The Cd0, deposited in situ on the CdS surface and detected by reduction of methylviologen, may act as a reduction site for photoexcited electrons toward a cyclic Schiff base intermediate produced by oxidation of DAP with pos. holes followed by deamination and intramol. condensation. Optically pure (R,R)- or (S,S)-PDCs were prepared successfully by photocatalytic reaction with the activated CdS particles using (R,R)- or (S,S)-DAPs, indicating that stereoselective conversion of organic compounds can be achieved via photocatalytic reaction under controlled conditions. The results came from multiple reactions, including the reaction of Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1Computed Properties of C7H11NO4)

Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Computed Properties of C7H11NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem