Category: 5773-58-0

5773-58-0, 3-Methylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5773-58-0

3-Methylpiperidin-4-one (1.34 g, 11.9 mmol) was dissolved in dichloromethane (30 ml), Et3N (6.12 ml) was added followed by 4-chlorobenzyl bromide (2.46 g, 12 mmol) and the reaction mixture was stirred at room temperature over night, partitioned between dichloromethane and water. The organic layer was dried over Na2SO4, filtered and the filtrate was concentrated in vacuo. The residue was dissolved in pyridine (30 ml), NH2OH HCl (1.53 g) was added and the mixture was stirred at room temperature over night, partitioned between ethyl acetate and water. The organic layer was washed with water, dried over Na2SO4, filtered and the filtrate was concentrated in vacuo to give l-(4- chlorobenzyl)-3-methylpiperidin-4-one-oxime (2.1 g). 1H-NMR (CDCl3, 400 MHz): 58.39 (br.s, IH); 7.28 (s, 4H); 3.47 (m, 2H); 3.00 (m, IH); 2.77 (m, 2H); 2.58 (m, IH); 2.26 (m, 2H); 2.05 (dd, J= 9.2, 11.0 Hz, IH); 1.08 (d, J= 6.6 Hz, 3H). APCI-MS : m/z 253 (MH+).

5773-58-0 3-Methylpiperidin-4-one 12284277, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ASTRAZENECA AB; WO2007/53082; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

5773-58-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5773-58-0,3-Methylpiperidin-4-one,as a common compound, the synthetic route is as follows.

A solution of N-(7-chloropyrazolo[ 1 ,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2- yl)benzamide (2D, 50 mg,0.151 mmol) and 3-methylpiperidin-4-one (34 mg,0.302 mmol) in NMP (0.950 mL) was stirred at 850C overnight. After cooling to room temperature, the mixture was diluted with a few drops of DMSO and methanol, and was then purified by preparatory HPLC, 30-55% ( MeCN/H2O gradient + 0.01% TFA). Lyophilization of the combined fractions gave the titled compound as a white solid (34 mg, 56%). 1H NMR (400 MHz, DMSO-J6) delta ppm 1.02 (d, J=6.57 Hz, 3 H) 1.46 (s, 6 H) 2.74 – 2.97 (m, 2 H) 3.30 (t, J=I 1.87 Hz, 1 H) 3.57 – 3.69 (m, 1 H) 4.56 – 4.70 (m, 2 H) 6.38 (d, J=2.27 Hz, 1 H) 7.48 (s, 1 H) 7.60 (d, J=8.59 Hz, 2 H) 8.00 (d, J=8.59 Hz, 2 H) 8.13 (d, J=2.27 Hz, 1 H) 10.93 (s, 1 H). ESI-MS: m/z 408.2 (M+H)+.

As the paragraph descriping shows that 5773-58-0 is playing an increasingly important role.

Reference：
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2009/123986; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem