Category: 5773-58-0

Meenal, K. Mrs. published the artcileThallium(III) acetate oxidation of some substituted-4-piperidones: a kinetic and mechanistic study, COA of Formula: C6H11NO, the main research area is oxidation piperidone thallium 3 kinetics.

Kinetics of oxidation of 4-piperidone, 3-methyl-2,6-diphenyl-4-piperidone, 3-alkyl-, and 3,3- and 3,5-dimethylpiperidone with Tl3+ in aqueous acetic acid in the presence of sulfuric acid at constant ionic strength (μ = 2.25 M) at 30-55° have been investigated. The reactions obey second order kinetics. Dependence on acidity is unity added sodium sulfate does not have any effect. Activation parameters have been calculated and the structure-reactivity relationships discussed. A mechanism involving fast enolization step is postulated.

Journal of the Indian Chemical Society published new progress about Oxidation. 5773-58-0 belongs to class piperidines, name is 3-Methylpiperidin-4-one, and the molecular formula is C6H11NO, COA of Formula: C6H11NO.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Tomoda, Shuji published the artcileOrigin of π-facial diastereoselection in hydride reduction of piperidones. The importance of ground-state effects, Recommanded Product: 3-Methylpiperidin-4-one, the main research area is facial stereoselectivity hydride reduction piperidinone FMO steric effect.

The exterior frontier orbital extension model (the EFOE Model) strongly suggested that the ground-state conformation (steric effects) and the anisotropic frontier orbital (LUMO) extension over π-faces may be the origin of the π-facial diastereoselection in hydride reductions of substituted piperidones.

Chemistry Letters published new progress about Conformation. 5773-58-0 belongs to class piperidines, name is 3-Methylpiperidin-4-one, and the molecular formula is C6H11NO, Recommanded Product: 3-Methylpiperidin-4-one.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Mayer, Brian P. published the artcileStatistical analysis of the chemical attribution signatures of 3-methylfentanyl and its methods of production, Category: piperidines, the main research area is forensic chem attribution signature methylfentanyl; 3-methylfentanyl; Chemical attribution signature; Chemical forensics; Forensic attribution; Machine learning; Opioid.

Chem. attribution of the origin of an illegal drug is a key component of forensic efforts aimed at combating illicit and clandestine manufacture of drugs and pharmaceuticals. The results of these studies yield detailed information on synthesis byproducts, reagents, and precursors that can be used to identify the method of manufacture In the present work, chem. attribution signatures (CAS) associated with the synthesis of the analgesic 3-methylfentanyl, N-(3-methyl-1-phenethylpiperidin-4-yl)-N-phenylpropanamide, were investigated. Eighteen crude samples from six synthesis methods were generated, the anal. of which was used to identify signatures (i.e., chem. compounds) that were important in the discrimination of synthetic route. These methods were carefully selected to minimize the use of scheduled precursors, complicated laboratory equipment, number of steps, and extreme reaction conditions. Using gas and liquid chromatogs. combined with time-of-flight mass spectrometry (GC-QTOF and LC-QTOF) over 160 distinct species were monitored. Anal. of this combined data set was performed using modern machine learning techniques capable of reducing the size of the data set, prioritizing key chem. attribution signatures, and identifying the method of production for blindly synthesized 3-methylfentanyl materials.

Talanta published new progress about Drugs of abuse. 5773-58-0 belongs to class piperidines, name is 3-Methylpiperidin-4-one, and the molecular formula is C6H11NO, Category: piperidines.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Sharma, Pankaj published the artcileOne-Pot Synthesis of Substituted Piperidinones and 3,4-Dihydropyrimidinones Using a Highly Active and Recyclable Supported Ionic Liquid Phase Organocatalyst, Product Details of C6H11NO, the main research area is piperidinone dihydropyrimidinone preparation silica supported ionic liquid organocatalyst.

1-Ethyl-3-methylimidazolium Et sulfate was synthesized and its supported ionic liquid phase form was prepared and used as an organocatalyst for the synthesis of substituted piperidinones and 3,4-dihydropyrimidinones. The ionic liquid was characterized by 1H NMR, 13C NMR, and mass spectrometry. The catalyst is novel, stable, completely heterogeneous, and recyclable for several times and can be easily recovered by filtration. It was characterized with SEM, TEM, TGA, and energy-dispersive x-ray spectroscopy techniques. The workup procedures are very simple, and products were obtained in good-to-excellent yields with reasonable purities without the need for further chromatog. purification

Australian Journal of Chemistry published new progress about Ionic liquids. 5773-58-0 belongs to class piperidines, name is 3-Methylpiperidin-4-one, and the molecular formula is C6H11NO, Product Details of C6H11NO.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Pillay, M. Krishna published the artcileConformational analysis of heterocyclic systems: part-III conformational analysis of substituted N-acetypiperidin-4-ones, Computed Properties of 5773-58-0, the main research area is acetypiperidinone conformational analysis NMR.

The conformations of various substituted N-acetylpiperidin-4-ones have been analyzed by IR, 1H NMR and 13C NMR data. On the basis of these results, acetyl group adopting a coplanar orientation with the dynamically averaged plane of the ring is proposed. The energy barrier ΔG# for the rotation of the acetyl group has been evaluated.

Indian Journal of Heterocyclic Chemistry published new progress about Acetyl group. 5773-58-0 belongs to class piperidines, name is 3-Methylpiperidin-4-one, and the molecular formula is C6H11NO, Computed Properties of 5773-58-0.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Hanson, Ronald L. published the artcileEnzymatic reduction of α-substituted ketones with concomitant dynamic kinetic resolution, Related Products of piperidines, the main research area is aminoketone reduction dynamic kinetic resolution; aminoalc enantioselective diastereoselective preparation.

Racemic α-substituted ketones were converted to the corresponding chiral alcs. with high diastereo- and enantioselectivities using enzymic reduction with concomitant dynamic kinetic resolution Reductions of N-protected α-amino ketones by microorganisms and com. enzymes provided N-protected α-amino alcs. Choice of buffer was found to be a crucial factor for the successful reduction and simultaneous dynamic resolution of an α-Me ketone to the corresponding chiral alc.

Journal of Molecular Catalysis B: Enzymatic published new progress about Diastereoselective synthesis. 5773-58-0 belongs to class piperidines, name is 3-Methylpiperidin-4-one, and the molecular formula is C6H11NO, Related Products of piperidines.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5773-58-0,3-Methylpiperidin-4-one,as a common compound, the synthetic route is as follows.,5773-58-0

The crude product from Step A above (14 g, 0.124 mol) was dissolved in DCM (500 mL) and treated with di-tert-butyl dicarbonate (32 g, 0.15 mol). The reaction mixture was stirred at rt for 2 h then N, N-dimethylethylene diamine (2 ML) was added and the and the reaction mixture was stirred for another 30 min. The reaction mixture was washed with 5% citric acid, saturated NAHCO3 solution and brine, dried over MGS04, filtered, and concentrated to give 20.7 g of desired PRODUCT. 1H NMR (500 MHz, CDC13) : 8 4.18 (m, 2H), 3.22 (m, 1H), 2.80 (m, 1H), 2.55 (m, 1H), 2.42 (m, 2H), 1.47 (s, 9H), 1.02 (d, 3H).

5773-58-0 3-Methylpiperidin-4-one 12284277, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; MERCK & CO., INC.; WO2004/41777; (2004); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

5773-58-0, 3-Methylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5773-58-0, The mixture of compound A0056-1 (115 mg, 1.02 mmol), compound 1 (323 mg, 1.53 mmol) and H2O (0.3 mL) was stirred overnight (about 18 hours) at room temperature. Thin-layer chromatography was used to monitor the reactions progress. The reaction mixture was quenched by extraction with ethyl acetate, followed by a washing with water and brine. The quenched reaction mixture was dried with anhydrous sodium sulfate and concentrated under vacuum to afford 300 mg of crude product as yellow oil. The crude product was purified via column chromatography to obtain 20 mg of the title product as colorless oil (yield: 6%) . The structure was confirmed by 1H NMR and MS.

The synthetic route of 5773-58-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; PAIN THERAPEUTICS, INC.; WO2010/51374; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

5773-58-0, 3-Methylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5773-58-0, 13.3: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate; 6.8 g of 3-methylpiperidin-4-one, 16.7 ml of triethylamine, 19.6 g of di-t-butyl dicarbonate and 0.7 g of dimethylaminopyridine are placed in a mixture of 300 ml of THF and 30 ml of water. Stirring is maintained at ambient temperature for 18 h. After evaporation of the THF, the reaction medium is treated with a saturated aqueous potassium hydrogen sulphate solution to a pH of 1, and then extraction is carried out with ethyl acetate until the aqueous phase is completely depleted. The organic phase is then washed with a saturated aqueous potassium hydrogen sulphate solution, and then with a saturated aqueous sodium hydrogen carbonate solution and, finally, with a saturated aqueous sodium chloride solution. After drying over MgSO4 and concentration to dryness, the crude obtained is chromatographed on silica gel, elution being carried out with a 98/2 dichloromethane/methanol mixture. 10.3 g of tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate are obtained.

As the paragraph descriping shows that 5773-58-0 is playing an increasingly important role.

Reference：
Patent; SANOFI-AVENTIS; US2007/191364; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5773-58-0,3-Methylpiperidin-4-one,as a common compound, the synthetic route is as follows.

1-(3-Chloropyridin-2-yl)-3-methylpiperidin-4-one was prepared by dissolving 19.2 g 3-methylpiperidin-4-one (168.9 mmol) and 25 g of Compound of Formula A (168.9 mmol) in DMSO (400 mL) under a nitrogen atmosphere to form a reaction mixture. The reaction mixture was stirred at 85 C for 12 hours. Therefter, the solvent was removed under reduced pressure. The residue was purified by column chromatography on a silica gel column, using a gradient of from 10:90 to 98:2 (by volume) ethyl acetate:hexane as an eluent, to provide 9 g of l-(3-chloropyridin-2-yl)-3-methylpiperidin-4-one., 5773-58-0

The synthetic route of 5773-58-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; EURO-CELTIQUE, S.A.; WO2005/4866; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem