Category: 54012-73-6

Downstream synthetic route of 54012-73-6

The synthetic route of 54012-73-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54012-73-6,Piperidin-3-amine,as a common compound, the synthetic route is as follows.

The steps will be a 2, 3 – diphenyl maleic anhydride (125g) and 3 – amino piperidine (50.1g) mixing, adding 1L dichloromethane, stirring at room temperature for 1 hour, the solvent is removed. Residue by adding acetic anhydride and sodium acetate mixture, heating to reflux 2 hours, after the reaction is complete, cooling, adding water and ethyl acetate extraction, to obtain the compound of formula d (150.5g, yield 90.6%)., 54012-73-6

The synthetic route of 54012-73-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Borui Bio-pharmaceutical (Suzhou) Co., Ltd.; Yuan Jiandong; (12 pag.)CN103450201; (2017); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

New learning discoveries about 54012-73-6

The synthetic route of 54012-73-6 has been constantly updated, and we look forward to future research findings.

54012-73-6,54012-73-6, Piperidin-3-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The steps will be a 3 – amino piperidine (50.1g) soluble in the 2L of in DMF, by adding 1, 2 – diphenyl vinylidene carbonate (119.1g), triethylamine (1L), for ice water bath stirring to the reaction is complete (about 30min) after, adding ethyl acetate, the combined organic layer, dried with anhydrous sodium sulfate, to remove the organic solvent. The resulting product is dissolved in the 1L trifluoroacetic in, as for 20 C stirring for 2 hours, concentrated in vacuo, to remove the surplus trifluoro acetic acid, to obtain a product of formula Chinese (148.5g, yield 92.3%)

The synthetic route of 54012-73-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Borui Bio-pharmaceutical (Suzhou) Co., Ltd.; Yuan Jiandong; (12 pag.)CN103450201; (2017); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Simple exploration of 54012-73-6

The synthetic route of 54012-73-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54012-73-6,Piperidin-3-amine,as a common compound, the synthetic route is as follows.

54012-73-6, In a sample bottle with stopper with a volume of 20 ml,1.00 g (10.0 mmol) of racemic 3-aminopiperidine,2.65 g (10.0 mmol) of N-p-toluyl-D-glutamic acid,5.55 g of methanol,And 0.97 g of water, and the mixture was heated to 60 C. for dissolution,10 mg of N-p-toluyl-D-glutamate of (S) -3-aminopiperidine was added.After cooling to 10 C.,After filtering the precipitated crystals,And dried to obtain 1.57 g of a salt.The optical purity of 3-aminopiperidine contained in the salt was 95.5% e. E. (S form).A portion of this salt was collected to quantify 3-aminopiperidine,The content rate is 27.5%This salt,It was confirmed to be a 1: 1 salt of 3-aminopiperidine and Np-toluyl-D-glutamic acid.Yield 43%.

The synthetic route of 54012-73-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TORAY FINE CHEMICALS CO LTD; FUJINO, TOSHIHIRO; HIRAGA, HISAFUMI; (9 pag.)JP5838590; (2016); B2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Downstream synthetic route of 54012-73-6

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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54012-73-6,Piperidin-3-amine,as a common compound, the synthetic route is as follows.

General procedure: To the solution of a corresponding amine (1.8 mmol) in DMF (5 mL) was added K2CO3 (2.0 mmol). The reaction mixture was stirred at room temperature for 30 min. After the addition of 2,6-dichloropyrazine (1.3 mmol) the reaction mixture was further stirred at room temperature for 15 h. After removal of solvent under reduced pressure, the precipitates formed by a treatment of residue with DCM:methanol (95:5) mixture was filtered off. Het-Cl was obtained by the removal of solvent in vaccuo and used for next reaction without further purification.

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Reference£º
Article; More, Kunal N.; Hong, Victor S.; Lee, Ahyeon; Park, Jongsung; Kim, Shin; Lee, Jinho; Bioorganic and Medicinal Chemistry Letters; vol. 28; 14; (2018); p. 2513 – 2517;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem