Category: 53617-35-9

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 53617-35-9, molcular formula is C9H18N2O, introducing its new discovery. Recommanded Product: 4-Morpholinopiperidine

A new series of monocyclic pseudopeptide tachykinin NK-2 receptor antagonists has been derived from the lead compound MEN11558. A synthesis for these molecules sharing the same intermediate was designed and performed. The replacement of the succinic moiety with an aspartic acid and the functionalization of its amino group with a wide variety of substituents led to very potent and selective NK-2 antagonists. Best results were obtained through the insertion in position 12 of an amino group with R configuration, linked by a short spacer to a saturated nitrogen heterocycle (morpholine, piperidine, or piperazine). The study led to compounds 54 and 57, endowed with high in vivo potency at very low doses and long duration of action in animal models of bronchoconstriction. In particular 54 and 57 completely inhibited NK-2 agonist induced bronchoconstriction in guinea pig after intratracheal administration at subnanomolar doses (ED50 = 0.27 nmol/kg and 0.15 nmol/kg, respectively).

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Recommanded Product: 4-Morpholinopiperidine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 53617-35-9

Reference：
Piperidine – Wikipedia,
Piperidine | C5H9795N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: 4-Morpholinopiperidine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 53617-35-9, Name is 4-Morpholinopiperidine, molecular formula is C9H18N2O. In a Patent, authors is £¬once mentioned of 53617-35-9

A preparation method of leti nepal (by machine translation)

The invention discloses a method for preparing leti nepal. The method of the invention to 2 – (4 – bromo – 3 – hydroxy-phenyl) acetic acid ethyl ester as the raw material, with the trifluoromethyl anhydride to trifluoromethanesulfonic acid esterification reaction, to obtain the trifluoromethanesulfonic acid ester compound; then with the other raw materials 4 – (4 – piperidinyl) morpholine substitution reaction, to obtain 2 – {4 – bromo – 3 – [4 – (morpholine – 4 – yl) piperidine – 1 – yl] phenyl} ethyl acetate; then the double-methylation reaction and hydrolysis reaction, the obtained 2 – {4 – bromo – 3 – [4 – (morpholine – 4 – yl) piperidine – 1 – yl] phenyl} – 2 – methyl propionic acid with malonic acid butyl uncle Shan condensation reaction, to obtain 4 – {4 – bromo – 3 – [4 – (morpholine – 4 – yl) piperidine – 1 – yl] phenyl} – 4 – methyl – 3 – oxo-pentanoic acid tert-butyl; through the use of classical reaction Fischer indole synthesis method, carbonyl and phenyl hydrazine in the next cyclization to form the indole acid catalysis mother nucleus, and finally through the cyclization reaction, sediment and catalytic coupling reaction, to prepare the leti nepal, the route method is reasonable in design, cheap, reaction condition is easy to effectively control. (by machine translation)

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 53617-35-9, help many people in the next few years.Recommanded Product: 4-Morpholinopiperidine

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H9722N – PubChem

 

Application of 53617-35-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.53617-35-9, Name is 4-Morpholinopiperidine, molecular formula is C9H18N2O. In a Patent£¬once mentioned of 53617-35-9

A preparation method of the midbody leti Nepal (by machine translation)

The invention discloses a leti Nepal intermediate 1, 1 – dimethyl – 6 – ethyl – 7 – [4 – (morpholine – 4 – yl) piperidine – 1 – yl] – 3, 4 – dihydro – 2 – naphthalenone preparation method. The method will be 6 – ethyl – 7 – methoxy – 3, 4 – dihydro – 2 – naphthalenone with iodomethane to carry out double-methylation reaction; the obtained 1, 1 – dimethyl – 6 – ethyl – 7 – methoxy – 3, 4 – dihydro – 2 – naphthalenone in hydrobromic acid aqueous solution in the hydrolysis reaction; the obtained 1, 1 – dimethyl – 6 – ethyl – 7 – hydroxy – 3, 4 – dihydro – 2 – naphthalenone with the trifluoromethyl anhydride to trifluoromethanesulfonic acid esterification reaction; the obtained 1, 1 – dimethyl – 6 – ethyl – 1, 2, 3, 4 – tetrahydro – 2 – oxo – 7 – naphthyl three fluorine armor sulfonic acid ester with 4 – (4 – piperidinyl) morpholine substitution reaction, to obtain 1, 1 – dimethyl – 6 – ethyl – 7 – [4 – (morpholine – 4 – yl) piperidine – 1 – yl] – 3, 4 – dihydro – 2 – naphthalenone. The preparation step of the method is relatively short, the operation is simplified, and the cost is low, is an environmental friendly technology method, is suitable for industrial production. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 53617-35-9

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H9726N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Product Details of 53617-35-9, Which mentioned a new discovery about 53617-35-9

Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists

Melanin concentrating hormone (MCH) is an important mediator of energy homeostasis and plays a role in metabolic and CNS disorders. The modeling-supported design, synthesis and multi-parameter optimization (biological activity, solubility, metabolic stability, hERG) of novel quinazoline derivatives as MCHR1 antagonists are described. The in vivo proof of principle for weight loss with a lead compound from this series is exemplified. Clusters of refined hMCHR1 homology models derived from the X-ray structure of the beta2-adrenergic receptor, including extracellular loops, were developed and used to guide the design.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 53617-35-9, help many people in the next few years.Product Details of 53617-35-9

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H9759N – PubChem