Category: 52763-21-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52763-21-0,Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

Step 1. Preparation of ethyl 1-benzyl-3-hydroxypiperidine-4-carboxylate (i-16b).A solution of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate, HC1 salt (20.0 g, 67.2 mmol) in MeOH (200 ml) in a 500 ml 3-neck flask equipped with thermocouple was cooled to 0C,followed by the additon of sodium borohydride (7.62 g, 201 mmol) portionwise over a period of 75 mm, avoiding excessive gas evolution. After addition, the mixture was stirred at room temperature for 2.5 hr. The mixture was cooled to 0C, quenched dropwise with 200 ml H20 and extracted into EtOAc. The combined organics were washed with water followed by brine, dried over Na2SO4, filtered and concentrated in vacuo to give ethyl 1-benzyl-3-hydroxypiperidine-4-carboxylate. LCMS (ESI) calc?d for C15H21N03 [M+H]: 264, found:264.

52763-21-0, The synthetic route of 52763-21-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; BARR, Kenneth Jay; MACLEAN, John; ZHANG, Hongjun; BERESIS, Richard Thomas; WO2014/28600; (2014); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

52763-21-0, Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,52763-21-0

General procedure: To a solution of sodium methoxide (25 wt-% in methanol) (67.6 mL, 296 mmol) and methanol (70 mL) at 25 C was added formamidine acetate (11.00 g, 106 mmol) and then ethyl N-benzyl-3-oxo-4-piperidine carboxylate hydrochloride (25.16 g, 84 mmol). The resulting mixture was stirred at 25 C for 20 h. The mixture was cooled to 0 C. Water (90mL) was added, followed by the dropwise addition of acetic acid (6.05 mL, 106 mmol), and the reaction mixture was stirred at 25 C for another 3 h. The mixture was reduced in volume under vacuum until most of the methanol had been removed. The suspension was filtered. The solids were washed with water and thendried under vacuum to afford 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one (16.10 g, 79 %) as an off-white solid; LC/MS:m/z 242.06 (M + H)+, 0.598 min (method 12). 1H-NMR (500 MHz, CDCl3) delta12.61 (br s, 1 H), 7.99 (s, 1 H), 7.38-7.26 (m, 5 H),3.73 (m, 2 H), 3.50 (m, 2 H), 2.74 (m, 2 H), 2.66 (m, 2 H).

The synthetic route of 52763-21-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Swidorski, Jacob J.; Liu, Zheng; Yin, Zhiwei; Wang, Tao; Carini, David J.; Rahematpura, Sandhya; Zheng, Ming; Johnson, Kim; Zhang, Sharon; Lin, Pin-Fang; Parker, Dawn D.; Li, Wenying; Meanwell, Nicholas A.; Hamann, Lawrence G.; Regueiro-Ren, Alicia; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 160 – 167;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52763-21-0,Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

Preparation 29: Ethyl 1-benzyl-3-oxo-4-(prop-2-en-1-yl)piperidine-4-carboxylate (P29)A mixture of potassium ferf-butoxide (3.77 g, 33. 58 mmol) in THF (100 m L) was stirred at RT for 0.5 h. The resulting milky solution was cooled to 0 C, and then Ethyl l-benzyl-3-oxopiperidine-4-carboxylate hydrochloride (5 g, 16.79 mmol) was added portion wise keeping the internal temperature below 5 C. The mixture was then warmed to RT and further stirred for 1 h, resulting in a yellow solution. After cooling to 0 C, allyl bromide (1.6 mL, 18.47 mmol) was added dropwise. The reaction mixture was warmed to RT and stirred overnight. The reaction solution was cooled to 0 C, and 50 m L of saturated N H4CI solution was added. After extraction and phase separation, the aqueous phase was extracted twice with 100 mL of EA. The combined organic phases were washed with 100 m L of saturated NaCI solution and dried; the solvent was evaporated under reduced pressure and the obtained crude material was purified by FC on silica gel (eluent: Cy to Cy/AcOEt 80/20) to give ethyl l-benzyl-3-oxo-4-(prop-2-en- l-yl)piperidine-4-carboxylate (p29, 4.23 g, y= 84%) as a yellow oil.MS (ES) (m/z): 302.23 [M+H]+., 52763-21-0

52763-21-0 Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride 2723880, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; SHIRE INTERNATIONAL GMBH; SEMERARO, Teresa; TARSI, Luca; MICHELI, Fabrizio; LUKER, Tim; CREMONESI, Susanna; (122 pag.)WO2016/42451; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem