Category: 5274-99-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5274-99-7,1-Benzoylpiperidine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

A mixed solution of methyl (2R, 3S)-2-AMINO-3- (LH-INDOL-3- yl) butanoate (1.28 g), 1-benzoylpiperidine-4-carboxylic acid (1.54 g), WSC (1.58 g) and HOBt (1.10 g) in acetonitrile (50 mL) was stirred at room temperature for 16 hrs. The reaction solution was diluted with ethyl acetate, a saturated aqueous solution of sodium carbonate was added and the mixture was subjected to extraction. The extract was purified by silica gel column chromatography (developing solvent: hexane/ethyl acetate = 1/1-1/4-ethyl acetate) to give the title compound as a pale yellow powder (2.01 g, yield 82%). LC/MS (ESI) m/z 448 (M+H+)., 5274-99-7

The synthetic route of 5274-99-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2004/46107; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

5274-99-7, 1-Benzoylpiperidine-4-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5274-99-7, To a mixture of tert-butyl (3-{[(2R, 3S)-2-AMINO-3-(LH- indol-3-yl) butanoyl amino} benzyl) carbamate (0.20 g, 0.47 MMOL), and 1-benzoylpiperidine-4-carboxylic acid (0.12 g, 0.53 mmol), WSC (0.11 g, 0.58 mmol) and HOBt (0.088 g, 0.57 mmol) were added THF (1.0 ML) and acetonitrile (1.0 ML) at room temperature, and the mixture was stirred overnight. To the reaction solution were added saturated aqueous solution of sodium hydrogen carbonate and ethyl acetate and the mixture was subjected to extraction. The organic layer was filtered by passing through a silica gel layer, and concentrated under reduced pressure. The residue was dissolved in dioxane (1.0 mL), and 4N hydrochloric acid-dioxane solution (1.0 ML) was added at room temperature. The mixture was stirred for 30 min. To the reaction solution were added saturated aqueous solution of sodium hydrogen carbonate and a mixed solvent of ethyl acetate-dichloromethane and the mixture was subjected to extraction. The organic layer was dried (MGS04) and concentrated under reduced pressure. The residue was purified by HPLC (acetonitrile/water = 10/90-100/0, containing 0.1% trifluoroacetic acid). A fraction of the object product was concentrated and neutralized with saturated aqueous solution of sodium hydrogen carbonate to give the title compound (0.084 g, yield 33%). LC/MS (ESI) m/z 538 (M+H+).

As the paragraph descriping shows that 5274-99-7 is playing an increasingly important role.

Reference：
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2004/46107; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

5274-99-7, 1-Benzoylpiperidine-4-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixed solution of methyl (2RS, 3SR)-2-amino-3-(1H-indol- 3-yl) butanoate (4.65 g), 1-benzoylpiperidine-4-carboxylic acid (5.13 g), WSC (5.75 g) and HOBt (4.60 g) in tetrahydrofuran (70 ML) WAS stirred at room temperature for 12 hrs. The reaction solution was diluted with ethyl acetate, a saturated aqueous sodium carbonate solution was added and the mixture was subjected to extraction. The organic layer was dried (MGS04) and the solvent was evaporated. The residue was purified by silica gel column chromatography (developing solvent: hexane/ethyl acetate = 1/1-ethyl acetate) to give the title compound as a pale yellow oil (7.86 g, yield 88%). 1H NMR (300 MHz, CDCl3) 8 ppm: 1.47 (d, J = 6.9 Hz, 3 H), 1.63 – 1. 83 (m, 4 H), 2.27-2. 35 (m, 1 H), 2.80-3. 00 (m, 2 H), 3.62-3. 78 (m, 4 H), 4.60 (brs, 1 H), 4.86-4. 96 (m, 1 H), 5.86-6. 02 (m, 1 H), 6.99 (d, J = 3.6 Hz, 1 H), 7.08-7. 20 (m, 2 H), 7.33-7. 40 (m, 6 H), 7.55-7. 60 (m, 1 H), 8.22- 8.28 (m, 1 H)., 5274-99-7

5274-99-7 1-Benzoylpiperidine-4-carboxylic acid 78935, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2004/46107; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem