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Among various wastewater treatment techniques, adsorption is supposed as one of the best methods due to its inexpensiveness, universal nature and ease of operation. Then, the use of agricultural waste for organic pollutants adsorption from aqueous solution has been reviewed. This article focuses on the preparation of activated carbon through various agricultural wastes and their modified. Moreover, the adsorption capacity for organic pollutants (such as dyes, petroleum hydrocarbons, pharmaceuticals, pesticides, and other organics) and desorption approaches have been investigated. In addition, optimization of activated carbon preparation conditions and adsorption process variables using response surface methodology (RSM) was also summarized. Adsorption mechanisms of organic pollutants are briefly discussed. The review implied the potential of agricultural wastes for organic pollutants removal from wastewater.

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Disclosed are compounds comprising a linker for increasing trans-cyclooctene stability. The linker of the invention is a three-arm linker. In some embodiments, one arm of the linker is attached to a trans-cyclooctene moiety, another arm is attached to a compound selected from the group consisting of antibodies, proteins, peptides, and peptoids, and the third arm extends into the solution.

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The synthesis of highly active, acridine derived antivirals is reported. A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA derived conjugate was synthesized in an easy sequence starting from 1,omega-alkyldiamines. As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by >8 logarithmic decades.

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The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, an antioxidant, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In some embodiments, the additive is a liquid. In other embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide or ester groups.

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 52722-86-8, molcular formula is C11H23NO2, introducing its new discovery. COA of Formula: C11H23NO2

Ditopic corroles with lanthanide-binding motifs were prepared and shown to be dual-range emitters, in the visible and near-IR, in ambient conditions.

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The aim of the study was to develop a self-emulsifying drug delivery systems (SEDDS) comprising chlorhexidine (CX) and monododecylamide-EDTA (alkyl-EDTA) exhibiting enhanced microbicidal properties. SEDDS containing 20% Captex 300, 45% Cremophor EL, 17% Tween 80 and 18% DMSO were loaded with 3% (m/v) alkyl-EDTA (FA) and formulations of 1% CX and 1.5% (m/v) alkyl-EDTA (FA-CX1% and FA-ED1.5%) were prepared separately as well as in combination (FA-CX1%ED1.5%). Resazurin assay was performed to assess the biocompatibility of SEDDS in concentrations of 0.5% and 1%. Alkyl-EDTA SEDDS were also evaluated for their binding affinity towards Ca2+ and Mg2+ as well as for augmented antimicrobial properties using E. coli as model germ. Biocompatibility assay of SEDDS revealed that >85% of cells remained viable after 4 h. SEDDS FA efficiently bound 770 ± 19 mumol/g of calcium and 784 ± 16 mumol/g of magnesium, respectively. SEDDS FA-CX1%ED1.5% showed a 34.3- and 12.9-fold enhanced antimicrobial effect compared to FA-ED1.5% and FA-CX1%, respectively. The combination of CX with alkyl-EDTA in SEDDS seems therefore to be a promising strategy to enhance the antimicrobial activity of this antiseptic drug.

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This study examined the interrelated effect of environmental pH, gelatin backbone modification and crosslinking modality on hydrogel morphology, surface hydrophilicity, in vitro swelling/degradation kinetics, in vitro drug release kinetics and in vivo degradation, inflammatory response and drug release activity. The percent glutaraldehyde fixation had a greater impact on the morphology of the dehydrated hydrogels than gelatin modification. Any decrease in percent glutaraldehyde fixation and/or modification of gelatin with polyethylene glycol dialdehyde (PEG-dial) and/or ethylenediaminetetraacetic dianhydride (EDTAD) increased hydrogel surface hydrophilicity. Swelling/degradation studies showed that modification of gelatin with PEG-dial generally increased the time to reach the maximum swelling weight ratio (Tmax) and the time to failure by hydrolysis (Tfail), but had little effect on the maximum swelling weight ratio (Rmax) and the weight ratio at failure (Rfail). Modification of gelatin with EDTAD generally had no effect on Tmax and Tfail, but increased Rmax and Rfail. Modification of gelatin with PEG-dial and EDTAD increased Rmax, but had no effect on Tmax, Rfail, or Tfail. Decreasing percent glutaraldehyde fixation generally increased Rmax and Rfail but decreased Tmax and Tfail. Decreasing environmental pH from 7.4 to 4.5 had no effect on any swelling/degradation properties. In vitro drug release studies showed that modification of gelatin with PEG-dial and/or EDTAD generally decreased the maximum mass ratio of drug released (Dmax) and the time to reach Dmax (Tdmax). Percent glutaraldehyde fixation did not significantly affect Dmax or Tdmax (except for EDTAD-modified gelatin hydrogels). In vivo studies showed that gelatin-based hydrogels elicited comparable levels of acute and chronic inflammatory response as that of the empty cage control by 21d.

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This paper reports on the preparation, characterization, and photoluminescence properties of novel hybrid materials, in which the EDTA?Ln?L complexes (where L: H2O, acac, bzac, dbm, and tta ligands, and Ln: Eu, Gd, and Tb) were covalently linked to the precursor medium molecular weight chitosan surface (CS) matrices or on the chitosan surfaces previously crosslinked with epichlorohydrin (CSech). The emission spectra of these materials were characterized by intraconfigurational-4fN transitions centred on the Eu3+ and Tb3+ ions. Some broad bands from the polymeric matrix were also observed in the emission spectra, however the relative intensities of the intraconfigurational bands increased significantly for systems containing diketonate ligands when the antenna effect became more efficient. The values of the radiative rates (Arad) were higher for crosslinked hybrid systems with epichlorohydrin, while nonradiative rates (Anrad) presented the opposite behaviour. These data contributed to an increase in the values of emission quantum efficiency (eta) for crosslinked materials. The effect of the modification process and antenna ligand on the values of intensities, intensity parameters Omega2 e Omega4 of the Eu3+ complexes were also investigated. The results showed that the crosslinked biopolymer surfaces have great potential for applications in molecular devices light converters.

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In order to enhance the adsorption capacity of oxalate decarboxylase (Oxdc) on calcium oxalate monohydrate crystals and improve the application performance of Oxdc, chemical modification of Oxdc with ethylenediaminetetraacetic dianhydride (EDTAD) was investigated in this work. The sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and liquid chromatography tandem mass spectrometry (LC/MS) analysis results demonstrated that Oxdc and EDTAD have been covalently bound, and suggested that the chemical modification occurred at the free amino of the side chain and the alpha-amine of the N-terminus of Oxdc. Fluorescene and circular dichroic measurement showed that the structure and conformation of Oxdc were tinily altered after modification by EDTAD. The optimum pH of EDTAD-modified Oxdc was shifted to the alkaline side about 1.5 unit and it has a higher thermostability. The analysis of kinetic parameters indicated that the EDTAD-modified Oxdc showed a higher affinity towards the substrate. Through modification the adsorption capacity of Oxdc onto CaOx monohydrate crystals was increased by 42.42%.

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(Figure Presented) Assembly of a mixture of guest-functionalized antenna and Eu3+-complexed ligand molecules in a patterned fashion onto a receptor surface provides efficient localized sensitized emission. Coordination of a carboxylate group of the antenna to the Eu3+ center and noncovalent anchoring of both components to the receptor surface appeared to be prerequisites for efficient energy transfer. A Job plot at the surface confirmed that coordination of the antenna to the Eu3+ center occurs in a 1:1 fashion. The efficiency of this intramolecular binding process is promoted by the high effective concentration of both complementary moieties at the surface. The system constitutes therefore an example of supramolecular expression of a complex consisting of several different building blocks which signals its own correct formation.

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