Category: 52157-82-1

Synthetic Route of 52157-82-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.52157-82-1, Name is 5-Methoxy-3-piperidin-4-yl-1H-indole, molecular formula is C14H18N2O. In a Patent，once mentioned of 52157-82-1

1Indolylpiperidine compounds of formula (I) wherein: A1 represents an alkylene, alkyleneoxy, alkylenethio, alkanoyl or hydroxyalkylene group; A2 represents a single bond, an alkylene or alkenylene group; W represents a single bond or a phenylene or furanylene group which is unsubstituted or substituted by one or more halogen atoms, alkoxy groups and/or alkyl groups; R1 represents a hydrogen atom or an alkyl, alkenyl, alkynyl, alkoxyalkyl, alkenyloxyalkyl, alkynyloxyalkyl alkoxy-alkoxyalkyl, phenylalkyl group wherein the phenyl ring is unsubstituted or substituted by one or more halogen atoms or alkyl, alkoxy or arylalkoxy groups, or a cycloalkylalkyl group wherein the cycloalkyl group is unsubstituted or substituted by one or more halogen atoms, alkyl groups or alkoxy groups; R2 represents a hydrogen or halogen atom or an alkyl or alkoxy group; and R3 represents a carboxyl group or a tetrazolyl group; and pharmaceutically acceptable salts thereof, process for their preparation and medicinal use.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 52157-82-1

Reference：
Piperidine – Wikipedia,
Piperidine | C5H18679N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Application In Synthesis of 5-Methoxy-3-piperidin-4-yl-1H-indole, Which mentioned a new discovery about 52157-82-1

The invention relates to novel sulfonamide compounds having 5-HT 7 receptor antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders. STR1wherein:Q is phenyl or thienyl;R 1 is halogen, hydroxy, C 1-6 alkyl, CF 3, OCF 3 or C 1-6 alkoxy;m is 0, 1, 2 or 3;R 2 is C 1-4 alkyl;X is carbon or CH,{character pullout} is a single bond when X is nitrogen or CH or{character pullout} is a double bond when X is carbon,D is a single bond, C O, O or CH 2 subject to the proviso that when X is nitrogen then D is not oxygen;P is a 5 or 6 membered heteroaryl ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or a benzofused heteroaryl ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur;R 3 is C 1-6 alkyl optionally substituted by NR 4 R 5, aryl, arylC 1-6 alkyl, C 1 6 alkoxy, C 1-6 alkylthio, cyano, hydroxy, nitro, halogen, CF 3, C 2 F 5, NR 4 R 5, CONR 4 R 5, NR 4 COR 5, S(O) p NR 4 R 5, CHO, OCF 3, SCF 3, CH 2 OR 6, CO 2 R 6 or COR 6 where p is 0, 1 or 2 and R 4, R 5 and R 6 are independently hydrogen, C 1-6 alkyl, aryl or arylC 1-6 alkyl;n is 0, 1, 2 or 3.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 52157-82-1, help many people in the next few years.Application In Synthesis of 5-Methoxy-3-piperidin-4-yl-1H-indole

Reference：
Piperidine – Wikipedia,
Piperidine | C5H18660N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Safety of 5-Methoxy-3-piperidin-4-yl-1H-indole, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 52157-82-1, Name is 5-Methoxy-3-piperidin-4-yl-1H-indole, molecular formula is C14H18N2O. In a Article, authors is Wei, Jianmei，once mentioned of 52157-82-1

High potency pyrazole-based noncovalent inhibitors of human cathepsin S (CatS) were developed by modification of the benzo-fused 5-membered ring heterocycles found in earlier series of CatS inhibitors. Although substitutions on this heterocyclic framework had a moderate impact on enzymatic potency, dramatic effects on cellular activity were observed. Optimization afforded indole- and benzothiophene-derived analogues that were high affinity CatS inhibitors (IC50 = 20-40 nM) with good cellular potency (IC50 = 30-340 nM).

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 52157-82-1, help many people in the next few years.Safety of 5-Methoxy-3-piperidin-4-yl-1H-indole

Reference：
Piperidine – Wikipedia,
Piperidine | C5H18669N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 52157-82-1, molcular formula is C14H18N2O, introducing its new discovery. , 52157-82-1

5-HT1F agonists for the treatment of migraine

This invention provides novel 5-HT1F agonists which are useful for the treatment of migraine and associated disorders.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 52157-82-1, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 52157-82-1

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H18655N – PubChem