Category: 51784-03-3

Chemistry is an experimental science, Safety of 2-(Piperidin-4-yl)benzo[d]oxazole, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 51784-03-3, Name is 2-(Piperidin-4-yl)benzo[d]oxazole

A series of benzoxazoles with a nitrogen-containing heterocyclic substituent at the 2-position was prepared and evaluated for 5-HT3 partial agonist activity on isolated guinea pig ileum. The nature of the substituent at the 5-position of the benzoxazole ring affected the potency for the 5-HTs receptor, and the 5-chloro derivatives showed increased potency and lowered intrinsic activity. 5-Chloro-7-methyl-2-(4-methyl-1- homopiperazinyl)benzoxazole (6v) exhibited a high binding affinity in the same range as that of the 5-HT3 antagonist granisetron, and its intrinsic activity was 12% of that of 5-HT. Compound 6v inhibited 5-HT-evoked diarrhea but did not prolong the transition time of glass beads in the normal distal colon even at a dose of 100 times the ED50 for diarrhea inhibition in mice. Compounds of this type are expected to be effective for the treatment of irritable bowel syndrome without the side effect of constipation.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of 2-(Piperidin-4-yl)benzo[d]oxazole, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 51784-03-3, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H15073N – PubChem

Application of 51784-03-3, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 51784-03-3, name is 2-(Piperidin-4-yl)benzo[d]oxazole. In an article，Which mentioned a new discovery about 51784-03-3

The discovery and synthesis of potential and novel antipsychotic coumarin derivatives, associated with potent dopamine D2, D3, and serotonin 5-HT1A and 5-HT2A receptor properties, are the focus of the present article. The most-promising derivative was 7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl)butoxy) -4-methyl-8-chloro-2H-chromen-2-one (17m). This derivative possesses unique pharmacological features, including high affinity for dopamine D2 and D3 and serotonin 5-HT1A and 5-HT2A receptors. Moreover, it possesses low affinity for 5-HT2C and H1 receptors (to reduce the risk of obesity associated with chronic treatment) and hERG channels (to reduce the incidence of torsade des pointes). In animal models, compound 17m inhibited apomorphine-induced climbing behavior, MK-801-induced hyperactivity, and the conditioned avoidance response without observable catalepsy at the highest dose tested. Further, fewer preclinical adverse events were noted with 17m compared with risperidone in assays that measured prolactin secretion and weight gain. Acceptable pharmacokinetic properties were also noted with 17m. Taken together, 17m may constitute a novel class of drugs for the treatment of schizophrenia.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.51784-03-3. In my other articles, you can also check out more blogs about 51784-03-3

Reference：
Piperidine – Wikipedia,
Piperidine | C5H15063N – PubChem

Synthetic Route of 51784-03-3, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 51784-03-3, Name is 2-(Piperidin-4-yl)benzo[d]oxazole,introducing its new discovery.

Provided is a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2. The present invention relates to a compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION. The compound has a selective MMP-9 production suppressive action, and is useful as a drug for the prophylaxis and/or treatment of autoimmune diseases such as rheumatoid arthritis and the like, inflammatory bowel diseases (ulcerative colitis, Crohn’s disease) or osteoarthritis.

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Piperidine – Wikipedia,
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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Quality Control of: 2-(Piperidin-4-yl)benzo[d]oxazole, Which mentioned a new discovery about 51784-03-3

The invention relates to novel sulfonamide compounds having 5-HT 7 receptor antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders. STR1wherein:Q is phenyl or thienyl;R 1 is halogen, hydroxy, C 1-6 alkyl, CF 3, OCF 3 or C 1-6 alkoxy;m is 0, 1, 2 or 3;R 2 is C 1-4 alkyl;X is carbon or CH,{character pullout} is a single bond when X is nitrogen or CH or{character pullout} is a double bond when X is carbon,D is a single bond, C O, O or CH 2 subject to the proviso that when X is nitrogen then D is not oxygen;P is a 5 or 6 membered heteroaryl ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or a benzofused heteroaryl ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur;R 3 is C 1-6 alkyl optionally substituted by NR 4 R 5, aryl, arylC 1-6 alkyl, C 1 6 alkoxy, C 1-6 alkylthio, cyano, hydroxy, nitro, halogen, CF 3, C 2 F 5, NR 4 R 5, CONR 4 R 5, NR 4 COR 5, S(O) p NR 4 R 5, CHO, OCF 3, SCF 3, CH 2 OR 6, CO 2 R 6 or COR 6 where p is 0, 1 or 2 and R 4, R 5 and R 6 are independently hydrogen, C 1-6 alkyl, aryl or arylC 1-6 alkyl;n is 0, 1, 2 or 3.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Quality Control of: 2-(Piperidin-4-yl)benzo[d]oxazole, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 51784-03-3

Reference：
Piperidine – Wikipedia,
Piperidine | C5H15061N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， SDS of cas: 51784-03-3, Which mentioned a new discovery about 51784-03-3

An approach to the parallel synthesis of hydantoin libraries by reaction of in situ generated 2,2,2-trifluoroethylcarbamates and alpha-amino esters was developed. To demonstrate utility of the method, a library of 1158 hydantoins designed according to the lead-likeness criteria (MW 200-350, cLogP 1-3) was prepared. The success rate of the method was analyzed as a function of physicochemical parameters of the products, and it was found that the method can be considered as a tool for lead-oriented synthesis. A hydantoin-bearing submicromolar primary hit acting as an Aurora kinase A inhibitor was discovered with a combination of rational design, parallel synthesis using the procedures developed, in silico and in vitro screenings.

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Piperidine – Wikipedia,
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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Product Details of 51784-03-3, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 51784-03-3, Name is 2-(Piperidin-4-yl)benzo[d]oxazole, molecular formula is C12H14N2O. In a Patent, authors is ，once mentioned of 51784-03-3

This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect.Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT3 receptor antagonism and serotonin 5-HT3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT3 receptor partial activators. In the above formula, R1 to R4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R1 and R2 may be linked together to form a ring structure, namely benzene ring; R5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Product Details of 51784-03-3

Reference：
Piperidine – Wikipedia,
Piperidine | C5H15053N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Formula: C12H14N2O, Which mentioned a new discovery about 51784-03-3

Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, chi ldhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (alsoknown as premenstrual syndrome), attention deficit disorder (wit h and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H15068N – PubChem

Chemistry is an experimental science, Computed Properties of C12H14N2O, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 51784-03-3, Name is 2-(Piperidin-4-yl)benzo[d]oxazole

A series of benzoxazole/benzothiazole-2,3-dihydrobenzo[b][1,4]dioxine derivatives (5a-5d and 8a-8j) was synthesized. Compounds were evaluated for binding affinities at the 5-HT1A and 5-HT2A receptors. Antidepressant activities of the compounds were screened using the forced swimming test (FST) and the tail suspension test (TST). The results indicated that the compounds exhibited high affinities for the 5-HT1A and 5-HT2A receptors and showed a marked antidepressant-like activity. Compound 8g exhibited high affinities for the 5-HT1A (Ki = 17 nM) and 5-HT2A (Ki = 0.71 nM) receptors; it also produced a decrease of the immobility time and exhibited potent antidepressant-like effects in the FST and TST in mice.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Computed Properties of C12H14N2O, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 51784-03-3, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H15074N – PubChem