Category: 50607-30-2

50607-30-2, Piperidine-2,4-dione is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 13 2-PYRIMIDIN-4-YT-1, 5, 6, 7-TETRAHYDRO-4H-PYRROLO JL 3, 2-CIPVRIDIN-4-O. NE HYD ROCHLORIDE 2-BROMO-1-PYRIMIDIN-4-YLETHANONE hydrobromide (67 mg, 0.239 MMOLS), piperidine-2,4-dione (50 mg, 0.358 MMOLS) and ammonium acetate (74 mg, 0.957 MMOLS) were dissolved in anhydrous ethanol (1 mL) and stirred at r. t. overnight. The reaction mixture was concentrated to dryness under reduced pressure and the residue was taken up with water (1 mL) and filtered; the solid was washed with cold water and dried. To the obtained brown solid (30 mg) dissolved in MEOH (15 mL), 4N HCI in dioxane (0.5 mL) was added and the mixture was stirred for 30 minutes and then concentrated under reduced pressure to half of the volume. The obtained precipitate was filtered, washed with ethyl acetate and dried to give the title compound as a yellow solid (31 mg, Y=52percent).

50607-30-2, As the paragraph descriping shows that 50607-30-2 is playing an increasingly important role.

Reference：
Patent; PHARMACIA & ITALIA S.p.A.; WO2005/14572; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

50607-30-2, Piperidine-2,4-dione is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50607-30-2, Step 1) 4-hydroxypiperidin-2-one [0258] To a solution of piperidine-2,4-dione (1 g, 8.8 mmol) in MeOH (25 mL) was added NaBH4 (1 g, 26.55 mmol) at 0°C. The reaction was stirred at rt overnight, then concentrated in vacuo. The residue was purified by a silica gel column chromatography (DCM/MeOH (v/v) = 5/1) to give the title compound as ayellow solid (960 mg, 87percent). LC-MS (ESI, pos. ion) m/z: 138[M + Na]+.

As the paragraph descriping shows that 50607-30-2 is playing an increasingly important role.

Reference：
Patent; XI, Ning; WANG, Tingjin; YI, Lei; WO2013/138210; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

50607-30-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50607-30-2,Piperidine-2,4-dione,as a common compound, the synthetic route is as follows.

To a round bottom flask charged with 3A (6.06 g, 19.21 mmol), piperidine-2,4-dione (2.391 g, 21.14 mmol), ammonium acetate (5.92 g, 77 mmol) and ethanol (64.0 ml) were added. The reaction mixture was stirred at rt for 2 h. Water (20 ml) was added and stirring was continued for 3 h. The product was collected via filtration. The collected solid was washed with water and dried under vacuum ON, yielding 3B (2.26 g, 9.12mmol, 47.5percent yield) as a white solid. MS(ES+) m/z 248.0 (M+H).

50607-30-2 Piperidine-2,4-dione 10887863, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; BRISTOL-MYERS SQUIBB COMPANY; HART, Amy C.; PITTS, William J.; MASTALERZ, Harold; GUO, Junqing; BROWN, Gregory D.; (148 pag.)WO2016/100166; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50607-30-2,Piperidine-2,4-dione,as a common compound, the synthetic route is as follows.,50607-30-2

[0239] 2,4-piperidinedione (1.0g, 8.84mmol) was dissolved in MeOH. NaBH4 (0.5g, 13.26mmol) was added at 0°C,stirred at 0°C for 30min, and the reaction mixture was then placed at room temperature and stirred for 1h. TLC (DCM/Me-OH) was employed to monitor the reaction. After the reaction completed, it was quenched by adding water and dried byspinning. Column chromatography afforded white solid powder 0.8g, yield 80.0percent.[0240] 1H NMR (400 MHz, DMSO-d6) delta 7.52-7.28 (s, 1H), 5.06-4.78 (d, J = 3.5 Hz, 1H), 4.03-3.78 (dp, J = 7.2,3.9,3.3Hz, 1H),3.28-3.14 (m, 1H),3.09-2.91 (dtt, J = 7.4, 5.2, 2.2 Hz, 1H), 2.42-2.25 (dd, J = 17.1,4.7 Hz, 1H), 2.13-1.93 (dd, J= 17.1, 6.1 Hz, 1H), 1.83-1.66 (ddt, J = 12.7, 7.9,3.6 Hz, 1H), 1.69-1.47 (dt, J = 13.2, 6.4 Hz, 1H).MS(ESI)m/z :[(M+1)+,117.1],

The synthetic route of 50607-30-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Zhe Jiang Jutai Pharmaceutical Co., Ltd; YANG, Yushe; XUE, Tao; DING, Shi; GUO, Bin; EP2947085; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem