Category: 50606-58-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50606-58-1,1-Benzylpiperidin-3-one hydrochloride,as a common compound, the synthetic route is as follows.

50606-58-1, Step 1: 1- benzyl-3-piperidone (44)Commercially available l-benzyl-3-piperidone monohydrochloride monohydrated salt (43) was neutralized with saturated sodium carbonate solution, extracted with EtOAc, dried over sodium sulphate, concentrated in vacuum and stripped with dry THF. The liquid mass was used as such for the next step.

As the paragraph descriping shows that 50606-58-1 is playing an increasingly important role.

Reference£º
Patent; ADVINUS THERAPEUTICS LIMITED; BARAWKAR, Dinesh; BENDE, Tanushree; ZAHLER, Robert; BANDYOPADHYAY, Anish; SARANGTHEM, Robindro Singh; DOSHI, Jignesh; WAMAN, Yogesh; JADHAV, Rushikesh; SINGH, Umesh Prasad; WO2012/127506; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

50606-58-1,50606-58-1, 1-Benzylpiperidin-3-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Benzyl-3-piperidine hydrochloride hydrate (1.02 g, 5.40 mmol) was suspended in methylene chloride, washed with 1 M NaOH, dried through cotton, and concentrated to give 1.02 g of free base material. The free base was dissolved in THF (40 mL) and cooled to 0 C. Phenyl magnesium bromide (3.0 M in ether, 8.10 mmol, 2.70 mL) was added dropwise over 30 min, at which point the solution was warmed to rt and stirred for 3 h. The mixture was then concentrated and the residue dissolved in methylene chloride. The resultant solution was washed with 10% saturated NH4Cl, dried through cotton and concentrated. Silica gel chromatography eluding with hexanes/ethyl acetate (3:1) gave 0.975 g of the title compound as a pale yellow oil.

50606-58-1 1-Benzylpiperidin-3-one hydrochloride 3084924, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; Pfizer Inc; US2006/19975; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem