Category: 50585-89-2

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， HPLC of Formula: C7H13NO2, Which mentioned a new discovery about 50585-89-2

The present invention relates to a compound of general formula (I) and/or its solvates, hydrates and pharmaceutically acceptable salts, which are modulators of glycine metabolism. The present invention also relates to the methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with glycine metabolism or a pathway where glycine decarboxylase (GLDC, or glycine cleavage system) plays a role. In a preferred embodiment the disorders/conditions/disease is cancer, inflammatory conditions, Alzheimer’s disease, metabolic disorders and CNS disorders.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 50585-89-2, help many people in the next few years.HPLC of Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7845N – PubChem

 

Electric Literature of 50585-89-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.50585-89-2, Name is Methyl piperidine-3-carboxylate, molecular formula is C7H13NO2. In a Patent，once mentioned of 50585-89-2

The present invention relates to compounds that are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 50585-89-2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7843N – PubChem

 

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 50585-89-2, molcular formula is C7H13NO2, introducing its new discovery. name: Methyl piperidine-3-carboxylate

Chemical modifications of RNA provide an additional, epitranscriptomic, level of control over cellular functions. N-6-methylated adenosines (m6As) are found in several types of RNA, and their amounts are regulated by methyltransferases and demethylases. One of the most important enzymes catalyzing generation of m6A on mRNA is the trimer N-6-methyltransferase METTL3-14-WTAP complex. Its activity has been linked to such critical biological processes as cell differentiation, proliferation, and death. We used in silico-based discovery to identify small-molecule ligands that bind to METTL3-14-WTAP and determined experimentally their binding affinity and kinetics, as well as their effect on enzymatic function. We show that these ligands serve as activators of the METTL3-14-WTAP complex. The methyltransferase complex METTL3-14-WTAP catalyzes generation of m6A on mRNA. Selberg et al. report the in silico discovery and experimental characterization of small-molecule compounds with exceptionally high binding efficiencies to METTL3-14-WTAP. Remarkably, these compounds act as enzyme activators and lead to increased m6A levels in RNA.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: Methyl piperidine-3-carboxylate, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 50585-89-2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7865N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Application In Synthesis of Methyl piperidine-3-carboxylate, Which mentioned a new discovery about 50585-89-2

Compound that is an inhibitor of at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Application In Synthesis of Methyl piperidine-3-carboxylate, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 50585-89-2

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Piperidine – Wikipedia,
Piperidine | C5H7864N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: 50585-89-2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50585-89-2, Name is Methyl piperidine-3-carboxylate, molecular formula is C7H13NO2. In a Patent, authors is £¬once mentioned of 50585-89-2

IMIDAZOPYRIDAZ1NE COMPOUNDS

The present invention relates to the use of novel compounds of formula (I): wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 50585-89-2, help many people in the next few years.Recommanded Product: 50585-89-2

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H7842N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C7H13NO2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50585-89-2, Name is Methyl piperidine-3-carboxylate, molecular formula is C7H13NO2. In a Patent, authors is £¬once mentioned of 50585-89-2

Aza spiro compound and its preparation method and application (by machine translation)

The invention discloses a nitrogen hetero-ring compound and its preparation method and application, which belongs to the field of pharmaceutical chemistry. The invention of the formula I structure characteristic of the aza volute apperception compound or its pharmaceutically acceptable salt or stereoisomer or solvate or prodrug, can be combined with the Autotaxin and as Autotaxin inhibitor, then can be applied to the prevention and treatment with Autotaxin expression is increased is characterized by pathology of the disease, such as cancer, fibrotic diseases, in particular pulmonary fibrosis and liver fibrosis, metabolic disease, myelodysplastic syndrome, cardiovascular diseases, autoimmune diseases, inflammation, nervous system disease or pain or the like. The series of compounds compared with the single inhibitor, various key signal path upstream of the block and interference, reducing or delaying the growth of tumor cells and transfer, can avoid drug premature drug resistance, while at the same time to tumor cells provide the possibility of new treatment. (by machine translation)

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Formula: C7H13NO2

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H7849N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50585-89-2,Methyl piperidine-3-carboxylate,as a common compound, the synthetic route is as follows.

Compound 4 (200 mg, 0.56 mmol), methyl 3-piperidinecarboxylate (80.2 mg, 0.56 mmol), triethylamine (0.25 mL, 1.68 mmol) and potassium iodide (11 mg, 0.067 mmol) were suspended in acetonitrile (10 mL) in a 15 mL tube. The mixture was stirred at room temperature for 4 h. The reaction was followed by TLC (DCM:MeOH = 100:1, Rf = 0.4). The solvent was steamed out from the mixture upon the completion of the reaction. The crude product was purified by flash chromatography (DCM:MeOH = 90:1) to yield compound 5e in the form of a yellow solid (167 mg, 71%). 1H NMR (600 MHz, Chloroform-d) delta = 8.60 (ddd, J = 1.9, 4.3, 8.9, 1H), 8.30 (s, 1H), 7.93 (dd, J = 1.8, 8.3, 1H), 7.83 (d, J = 8.2, 1H), 7.54 (dd, J = 3.0, 6.2, 1H), 7.45 (td, J = 4.3, 6.1, 7.4, 1H), 3.68 – 3.61 (m, 5H), 2.90 (d, J = 11.4, 1H), 2.60 (d, J = 11.3, 1H), 2.28 (d, J = 10.6, 1H), 2.13 (t, J = 11.1, 2H), 1.91 (d, J = 12.9, 1H), 1.76 – 1.70 (m, 1H), 1.59 (d, J = 12.1, 1H), 1.48 (d, J = 13.7, 1H). 13C NMR (151 MHz, Chloroform-d) delta = 181.70 (d, J = 2.7), 178.08, 174.49, 161.92, 160.26, 157.93, 145.59, 144.06, 142.42 (d, J = 2.4), 135.97, 130.74, 127.36, 124.79 (d, J = 23.9), 123.38, 119.68 (d, J = 7.5), 112.02 (d, J = 24.4), 62.44, 55.28, 53.73, 51.68, 29.60, 26.69, 24.41. HPLC tR = 1.989 min, purity 96.76%. HR-MS (ESI): calcd. for C23H20FN3NaO4 [M+Na]+: 444.1336, found: 444.1336.

50585-89-2, As the paragraph descriping shows that 50585-89-2 is playing an increasingly important role.

Reference£º
Article; Cui, Menghan; Kuang, Chunxiang; Li, Yuanyuan; Liu, Wei; Wang, Rong; Yang, Qing; Zhang, Shengnan; Bioorganic and medicinal chemistry letters; (2020);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

50585-89-2, Methyl piperidine-3-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50585-89-2, Potassium 3-methoxycarbonyl-piperidine-1-carbodithioate (13 Kmpc) was prepared by the dropwise addition of 14 CS2 (1.2mL, 20mmol) into a solution of methyl nipecotate (2.8mL, 20mmol) in 15 methanol (30mL) in the presence of 16 KOH (1.2g, 20mmol), stirring the reaction mixture for 1h. The yellow solid which separated was filtered off, washed with ethanol and thereafter with ether and dried (Scheme 2 ). Yield: 80%; m.p. 202C. Anal. Found: C, 37.15; H, 4.88; N, 5.70; S, 24.58%. Calc. for C8H12NO2S2K (257.40): C, 37.32; H, 4.70; N, 5.44; S, 24.91%. IR (KBr, cm-1): nu(C-H) 2944, 2857; nu(C=O) 1658; nu(CN) 1565; nu(C=S) 1012. 1H NMR (CDCl3: delta, ppm): 1.68-2.43 (m, H-3, H-4, H-5), 2.64 (t, 2H, H-6axial), 2.91 (d, 2H, H6-equatorial), 2.82 (t, 2H, H-2axial), 3.13 (d, 2H, H-2equatorial), 4.09 (s, 3H, -OCH3). 13C NMR (CDCl3: delta, ppm): 23.88-49.99 (piperidine ring), 51.01 (-OCH3), 173.50 (C=O), 212.46 (C=S).

The synthetic route of 50585-89-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nath, Paras; Bharty; Kushawaha; Maiti; Polyhedron; vol. 151; (2018); p. 503 – 509;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem