Category: 50541-93-0

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 50541-93-0, molcular formula is C12H18N2, introducing its new discovery. Application In Synthesis of 4-Amino-1-benzylpiperidine

The current research aimed to investigate the importance of the heterocyclic ring system in the structure of the cardiovascular drug diltiazem for its calcium channel blocking activity. The manuscript describes the design, synthesis, and biological testing of a total of 10 S-(p-methoxybenzyl), N-substituted thiosalicylamides as a series of non-cyclic compounds derived from diltiazem’s structure. The new compounds maintained all diltiazem pharmacophores except the thiazepine ring system. In vitro evaluation of the new series for calcium channel blocking effects revealed moderate activities with IC50 values in the range of 4.8-56.0 muM. The data suggest that the ring system is not essential for activity; however, its absence leads to a considerable drop of activity relative to that of diltiazem (IC50 = 0.3 muM). Compounds of the current series showed optimum activity when the aliphatic alkyl chain on the salicylamide nitrogen is part of a piperidine or piperazine ring system substituted at the terminal nitrogen with a benzyl group.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H12404N – PubChem

Chemistry is an experimental science, name: 4-Amino-1-benzylpiperidine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 50541-93-0, Name is 4-Amino-1-benzylpiperidine

Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R4, E, T, n and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H11864N – PubChem

Related Products of 50541-93-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50541-93-0, Name is 4-Amino-1-benzylpiperidine, molecular formula is C12H18N2. In a Article，once mentioned of 50541-93-0

The CC chemokines may play an important role in the pathogenesis of chronic inflammatory diseases including rheumatoid arthritis, and their effects are thought to be mediated through CCR1 receptors. Several nonpeptide CCR1 receptor antagonists that showed high affinity for human CCR1 receptors have been identified; however, their effectiveness in animal models of inflammatory diseases has been scarcely demonstrated, probably due to species selectivity of the antagonists. To elucidate the pathophysiological role of CCR1 receptors in murine models of disease, we looked for a potent antagonist for both murine and human CCR1 receptors. Screening of our chemical collection for inhibition of 125I-MIP-1alpha binding to human CCR1 receptors transfected in CHO cells led to the identification of xanthene-9-carboxamide 1a as the lead compound. Derivatization of 1a by quaternarizing the piperidine nitrogen with various alkyl groups and by installing substituents into the xanthene moiety dramatically improved the inhibitory activity against both human and murine CCR1 receptors. As a result, 2q-1 showing IC50 values of 0.9 and 5.8 nM for human and murine CCR1 receptors, respectively, was discovered. This compound is the first murine CCR1 receptor antagonist and may be a useful tool for clarifying the role of CCR1 receptors in murine models of disease.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H12406N – PubChem

Related Products of 50541-93-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.50541-93-0, Name is 4-Amino-1-benzylpiperidine, molecular formula is C12H18N2. In a Patent，once mentioned of 50541-93-0

The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.

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Piperidine – Wikipedia,
Piperidine | C5H12331N – PubChem

Electric Literature of 50541-93-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 50541-93-0, Name is 4-Amino-1-benzylpiperidine, molecular formula is C12H18N2. In a Article，once mentioned of 50541-93-0

Starting from the molecular simplification of (R) 4-(3,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide 9a, a compound endowed with selectivity for human Carbonic Anhydrase (hCA) IV, a series of piperazines and 4-aminopiperidines carrying a 4-sulfamoylbenzamide moiety as Zn-binding group have been designed and tested on human isoforms hCA I, II, IV and IX, using a stopped flow CO2 hydrase assay. The aim of the work was to derive structure-activity relationships useful for designing isoform selective compounds. These structural modifications changed the selectivity profile of the analogues from hCA IV to hCA I and II, and improved potency. Several of the new compounds showed subnanomolar activity on hCA II. X-ray crystallography of ligand-hCAII complexes was used to compare the binding modes of the new piperazines and the previously synthesized 2-benzyl-piperazine analogues, explaining the inhibition profiles.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H12418N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C12H18N2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50541-93-0, Name is 4-Amino-1-benzylpiperidine, molecular formula is C12H18N2. In a Patent, authors is ，once mentioned of 50541-93-0

Disclosed are compounds of the Formula I wherein:Z is C or nothing, provided that when Z is nothing, R 3and R 4are nothing;A is S, S=O or O=S=O;R 1 and R 2are independently hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy, (un)substituted aryl, (un)substituted arylalkyl, (un) substituted heteroaryl or(un)substituted heteroarylakyl;R 3and R 4independently represent hydrogen, lower alkyl, cycloalkyl, aminoalkyl, mono-or dialkylaminoalkyl, (un)substituted aryl or (un) substituted heteroaryl;R 5represents a (un)substituted carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms; orR 5is (CR 6R 7)–(CH 2) n–XR 8R 9;X is S or N;R 6, R 7, R 8, R 9, and n are as defined in the specification.The compounds are useful in the treatment and prevention of the AIDS virus. Intermediates useful in the preparation of the final products, pharmaceutical compositions containing the final products are also taught.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. COA of Formula: C12H18N2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H12536N – PubChem

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 50541-93-0, molcular formula is C12H18N2, introducing its new discovery. Safety of 4-Amino-1-benzylpiperidine

The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and nonneoplastic diseases.

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Piperidine – Wikipedia,
Piperidine | C5H12371N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， category: piperidines, Which mentioned a new discovery about 50541-93-0

Previously reported pyrrolones, such as TDR32570, exhibited potential as antimalarial agents; however, while these compounds have potent antimalarial activity, they suffer from poor aqueous solubility and metabolic instability. Here, further structure-activity relationship studies are described that aimed to solve the developability issues associated with this series of compounds. In particular, further modifications to the lead pyrrolone, involving replacement of a phenyl ring with a piperidine and removal of a potentially metabolically labile ester by a scaffold hop, gave rise to derivatives with improved in vitro antimalarial activities against Plasmodium falciparum K1, a chloroquine- and pyrimethamine-resistant parasite strain, with some derivatives exhibiting good selectivity for parasite over mammalian (L6) cells. Three representative compounds were selected for evaluation in a rodent model of malaria infection, and the best compound showed improved ability to decrease parasitaemia and a slight increase in survival.

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Piperidine – Wikipedia,
Piperidine | C5H11815N – PubChem

Electric Literature of 50541-93-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.50541-93-0, Name is 4-Amino-1-benzylpiperidine, molecular formula is C12H18N2. In a article，once mentioned of 50541-93-0

A number of new carboxamide derivatives were synthesized. The affinity of these compounds for the serotoninergic 5-HT4 receptor was evaluated by use of radioligand-binding techniques. The agonistic activity was evaluated as the contractile effect of the ascending colon isolated from guinea-pigs. Among these compounds, 4-amino-5-chloro-2-methoxy-N-[l-[2- [(methylsulfonyl)amino]ethly]-4piperidinylmethyl]benzamide (24) showed a high affinity for the 5-HT4 receptor (Ki = 9.6 nM). Compound 24 displayed a higher affinity for 5-HT4 receptors than the other receptors, including, 5- HT3 and dopamine D2 receptors. In addition, compound 24 was confirmed to be a potent 5-HT4 receptor agonist (ED50 = 7.0 nM). An interaction model between compound 24 and 5-HT4 receptor was proposed.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H12020N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of: 4-Amino-1-benzylpiperidine. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 50541-93-0

Upregulation of pyruvate dehydrogenase kinase (PDHK) has been observed in a variety of cancers. Inhibition of PDHK offers an attractive opportunity for the development of novel cancer therapies. To obtain novel PDHK inhibitors, we took advantage of the homology of the ATP-binding pocket between Heat Shock Protein 90 (HSP90) and PDHK, and utilized 4,5-diarylisoxazole based HSP90 inhibitor for structural design. Our efforts led to the identification of 5k that inhibited PDHK1 with an IC50 value of 17 nM, which, however, showed marginal cellular activity. Further structural optimization resulted in compound 11a with improved cellular activity which could effectively modulate the metabolic profile of cancer cells and lead to the inhibition of cancer cell proliferation, evidenced by the increased oxidative phosphorylation and decreased glycolysis and associated oxidative stress. Our results suggested 11a as an excellent lead compound and a favorable biological tool to further evaluate the therapeutic potential of PDHK and HSP90 dual inhibitors in the treatment of cancer.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H12128N – PubChem