Category: 50461-59-1

Yang, Hao; Murigi, Francis N.; Wang, Zhijian; Li, Junfeng; Jin, Hongjun; Tu, Zhude published an article on February 15 ,2015. The article was titled 《Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Name: 4-(Pyridin-3-yl)piperidin-4-ol The information in the text is summarized as follows:

Fifteen cinnoline analogs and six benzimidazole phosphodiesterase 10A (PDE10A) inhibitors were synthesized as potential PET radiopharmaceuticals and their in vitro activity as PDE10A inhibitors was determined Nine out of twenty-one compounds were potent inhibitors of PDE10A with IC50 values ranging from 1.5 to 18.6 nM. Notably, the IC50 values of compounds I [R = H, F] and II were 1.52 ± 0.18, 2.86 ± 0.10, and 3.73 ± 0.60 nM, resp.; these three compounds also showed high in vitro selectivity (>1000-fold) for PDE10A over PDE 3A/3B, PDE4A/4B. The high potency and selectivity of these three compounds suggests that they could be radiolabeled with PET radionuclides for further evaluation of their in vivo pharmacol. behavior and ability to quantify PDE10A in the brain. After reading the article, we found that the author used 4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1Name: 4-(Pyridin-3-yl)piperidin-4-ol)

4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Name: 4-(Pyridin-3-yl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer》 was written by Bradbury, Robert H.; Acton, David G.; Broadbent, Nicola L.; Brooks, A. Nigel; Carr, Gregory R.; Hatter, Glenn; Hayter, Barry R.; Hill, Kathryn J.; Howe, Nicholas J.; Jones, Rhys D. O.; Jude, David; Lamont, Scott G.; Loddick, Sarah A.; McFarland, Heather L.; Parveen, Zaieda; Rabow, Alfred A.; Sharma-Singh, Gorkhn; Stratton, Natalie C.; Thomason, Andrew G.; Trueman, Dawn; Walker, Graeme E.; Wells, Stuart L.; Wilson, Joanne; Wood, J. Matthew. Synthetic Route of C10H14N2O And the article was included in Bioorganic & Medicinal Chemistry Letters on April 1 ,2013. The article conveys some information:

Removal of the basic piperazine nitrogen atom, introduction of a solubilising end group and partial reduction of the triazolopyridazine moiety in the previously-described lead androgen receptor downregulator 6-[4-(4-cyanobenzyl)piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine (1) addressed hERG and phys. property issues, and led to clin. candidate 6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine (12), designated AZD3514, that is being evaluated in a Phase I clin. trial in patients with castrate-resistant prostate cancer. In the experimental materials used by the author, we found 4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1Synthetic Route of C10H14N2O)

4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Synthetic Route of C10H14N2O

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The author of 《Light-Mediated Formal Radical Deoxyfluorination of Tertiary Alcohols through Selective Single-Electron Oxidation with TEDA2+.》 were Aguilar Troyano, Francisco Jose; Ballaschk, Frederic; Jaschinski, Marcel; Oezkaya, Yasemin; Gomez-Suarez, Adrian. And the article was published in Chemistry – A European Journal in 2019. Recommanded Product: 50461-59-1 The author mentioned the following in the article:

The synthesis of tertiary alkyl fluorides through a formal radical deoxyfluorination process was described. This light-mediated, catalyst-free methodol. was fast and broadly applicable allowing for the preparation of C-F bonds from (hetero)benzylic, propargylic and non-activated tertiary alc. derivatives Preliminary mechanistic studies supported that the key step of the reaction is the single-electron oxidation of cesium oxalates-which are readily available from the corresponding tertiary alcs.-with in situ generated TEDA2+ (TEDA: N-(chloromethyl)triethylenediamine), a radical cation derived from Selectfluor. The experimental process involved the reaction of 4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1Recommanded Product: 50461-59-1)

4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Recommanded Product: 50461-59-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer》 was written by Bradbury, Robert H.; Acton, David G.; Broadbent, Nicola L.; Brooks, A. Nigel; Carr, Gregory R.; Hatter, Glenn; Hayter, Barry R.; Hill, Kathryn J.; Howe, Nicholas J.; Jones, Rhys D. O.; Jude, David; Lamont, Scott G.; Loddick, Sarah A.; McFarland, Heather L.; Parveen, Zaieda; Rabow, Alfred A.; Sharma-Singh, Gorkhn; Stratton, Natalie C.; Thomason, Andrew G.; Trueman, Dawn; Walker, Graeme E.; Wells, Stuart L.; Wilson, Joanne; Wood, J. Matthew. Recommanded Product: 50461-59-1 And the article was included in Bioorganic & Medicinal Chemistry Letters on April 1 ,2013. The article conveys some information:

Removal of the basic piperazine nitrogen atom, introduction of a solubilising end group and partial reduction of the triazolopyridazine moiety in the previously-described lead androgen receptor downregulator 6-[4-(4-cyanobenzyl)piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine (1) addressed hERG and phys. property issues, and led to clin. candidate 6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine (12), designated AZD3514, that is being evaluated in a Phase I clin. trial in patients with castrate-resistant prostate cancer. In the experimental materials used by the author, we found 4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1Recommanded Product: 50461-59-1)

4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Recommanded Product: 50461-59-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The author of 《Light-Mediated Formal Radical Deoxyfluorination of Tertiary Alcohols through Selective Single-Electron Oxidation with TEDA2+.》 were Aguilar Troyano, Francisco Jose; Ballaschk, Frederic; Jaschinski, Marcel; Oezkaya, Yasemin; Gomez-Suarez, Adrian. And the article was published in Chemistry – A European Journal in 2019. Quality Control of 4-(Pyridin-3-yl)piperidin-4-ol The author mentioned the following in the article:

The synthesis of tertiary alkyl fluorides through a formal radical deoxyfluorination process was described. This light-mediated, catalyst-free methodol. was fast and broadly applicable allowing for the preparation of C-F bonds from (hetero)benzylic, propargylic and non-activated tertiary alc. derivatives Preliminary mechanistic studies supported that the key step of the reaction is the single-electron oxidation of cesium oxalates-which are readily available from the corresponding tertiary alcs.-with in situ generated TEDA2+ (TEDA: N-(chloromethyl)triethylenediamine), a radical cation derived from Selectfluor. The experimental process involved the reaction of 4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1Quality Control of 4-(Pyridin-3-yl)piperidin-4-ol)

4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Quality Control of 4-(Pyridin-3-yl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem