Category: 503614-92-4

Related Products of 503614-92-4, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 503614-92-4, Name is 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid, molecular formula is C25H24N4O5. In a Patent，once mentioned of 503614-92-4

This invention provides a process for preparing apixaban, comprising reacting a carboxylic acid derivative with an activating agent and a source of ammonia.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Related Products of 503614-92-4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 503614-92-4, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H24010N – PubChem

Related Products of 503614-92-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.503614-92-4, Name is 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid, molecular formula is C25H24N4O5. In a article，once mentioned of 503614-92-4

The present invention provides a process for the preparation and purification of apixaban.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 503614-92-4, and how the biochemistry of the body works.Related Products of 503614-92-4

Reference：
Piperidine – Wikipedia,
Piperidine | C5H24011N – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 503614-92-4, name is 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid, introducing its new discovery. Quality Control of: 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid

Apixaban is a novel anticoagulant drug acting as a direct, selective and reversible inhibitor of the coagulation factor Xa. Forced degradation under stress conditions were carried out in order to establish its stability profile. The drug was shown to be stable under photolytic, thermolytic and oxidative conditions, while under hydrolytic conditions, up to seven degradation products were generated for about 15% of drug degradation. The degradation products have been detected by linear gradient reversed phase high-performance liquid chromatography coupled with a photo diode array and with electrospray ionization tandem mass spectrometry. A combination of multistage mass spectrometry and high-resolution mass spectrometry (HR-MS) allowed the structural elucidation. The product ions of the degradation products were compared to those of the apixaban protonated ion so as to assign the most structures possible. This required a study in depth of the drug’s fragmentation pattern, which has not been reported so far. In view of the products formed, it appears that hydrolysis of the oxopiperidine moiety of apixaban occurred in acidic medium, whereas that of the tetrahydro-oxo-pyridine moiety would further happen under alkaline conditions. Asides from characterization, the LC method was shown to indicate stability and validated as per the criteria described by the ICH guidelines.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 503614-92-4 is helpful to your research. Quality Control of: 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid

Reference：
Piperidine – Wikipedia,
Piperidine | C5H24023N – PubChem

Application of 503614-92-4, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 503614-92-4, name is 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid. In an article，Which mentioned a new discovery about 503614-92-4

A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. 1These compounds are useful as factor Xa inhibitors.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.503614-92-4. In my other articles, you can also check out more blogs about 503614-92-4

Reference：
Piperidine – Wikipedia,
Piperidine | C5H24026N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.503614-92-4,1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid,as a common compound, the synthetic route is as follows.,503614-92-4

General procedure: A solution of 5,6-dihydro-3- (4-morpholinyl) -1- [4- (2-oxo-1-piperidinyl) phenyl]2 (1H) -pyridone and ethyl [(4-methoxyphenyl) hydrazino] chloroacetate,In the triethylamine for the acid binding agent under the conditions of condensation, and then by hydrochloric acid deprotection,The resulting intermediates,In the ethylene glycol under high temperature conditions with ammonia reaction in the preparation of an average of apixaban, the purity of 95.4%.In the 50L reactor,Add 2 kg of apixaban crude (purity 95. 4%) and 16L with 10% ammonia in ethylene glycol solution, heated to 90 C dissolved, then add 16L water cooling, stirring at 40 ~ 50 C for 2 hours , Cooling to 0 ~ 10 C. And then filtered to dryness to give 8 kg of a white solid, 90% yield, and an HPLC purity of 99. 97%.

503614-92-4 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid 22240440, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Zhongmei HuashitongBiotechnology Pharmaceutical Technology (Wuhan) Co.,Ltd; HU, MINGLONG; WU, HAOHAO; CUI, JIAN; QIAN, LINA; (13 pag.)CN106188036; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

503614-92-4, 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

503614-92-4, 12.5 g (27.1 mmol) of substance of formula 11c obtained in example 10 is suspended in DMA, then under argon atmosphere 8.0 g (49.3 mmol) of carbonyldiimidazole (CDI) is added, and the mixture is heated to 60 C, and it is maintained at this temperature for 1 hour. Then 18.8 mL (13.7 g, 136 mmol) of triethylamine and 6.25 g (81 mmol) of ammonium acetate are added to the mixture. The stirring is continued for 1 hour. Water is added to the mixture and the suspension is slowly cooled to 20 C. The precipitated substance is filtered off and washed. After drying 11.36 g (24.7 mmol, 91%) of off-white substance is obtained. Mp.: 236-238 C.

The synthetic route of 503614-92-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; EGIS GYOGYSZERGYAR ZRT.; MRAVIK, Andras; NAGY, Tamas; FARAGO, Janos; VOLK, Balazs; LUKACS, Gyula; NEMETH, Gabor; CZOBORNE HATVARI, Ilona; SLEGEL, Peter; CSONKA-KIS, Gy?z?; KORMANY, Robert; (39 pag.)WO2016/20711; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem