Category: 4897-50-1

4897-50-1, 4-Piperidinopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1.; Preparation of 1-chlorocarbonyl-4-piperidinopiperidine base (IRT-4):; Dissolving 4-piperdinoperidine (100g) in benzene (1580ml) under stirring for 15 to 30 minutes at room temperature, adding a solution of triphosgene (150g) in benzene (660 ml) over a period of 1 to 3 hours at a temperature of 20¡ã- 25¡ãC. Filtering the solid, washing it with benzene and drying, then dissolve the dried solid in chloroform (5900 ml) by stirring at room temperature for about 30 minutes. Charging aqueous sodium bicarbonate solution (400 ml), stirring and separating chloroform layer, washing the chloroform layer with water (1800 ml), separating chloroform layer anddistilling off chloroform under vacuum at a temperature up to below 45¡ãC to obtain 1-chlorocorbonyl-4-piperidopiperidine base (60 g).

4897-50-1, The synthetic route of 4897-50-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SHILPA MEDICARE LIMITED; WO2006/16203; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4897-50-1,4-Piperidinopiperidine,as a common compound, the synthetic route is as follows.

General procedure: 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HATU; 1.2 equivalents) was added to a solution of the corresponding alpha-methyl carboxylic acid (2) (1 equiv), the appropriate amine (1.5 equiv) and DIEA (2 equiv) in dry acetonitrile (10 mL) at room temperature under argon atmosphere. The reaction mixture was stirred at room temperature overnight. Solvent was evaporated under reduced pressure, and the crude product was purified using a Teledyne Isco Combiflash? Rf purification machine using 0-10percent CHCl3/methanol as eluent to provide the desired amides 3-59 in 68-95percent yields., 4897-50-1

As the paragraph descriping shows that 4897-50-1 is playing an increasingly important role.

Reference£º
Article; Mathew, Bini; Snowden, Timothy S.; Connelly, Michele C.; Guy, R. Kiplin; Reynolds, Robert C.; Bioorganic and Medicinal Chemistry Letters; vol. 28; 12; (2018); p. 2136 – 2142;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4897-50-1,4897-50-1, 4-Piperidinopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 101: 2-{[(5E)-2-(l,2-diazinan-l-yl)-4-oxo-4,5-dihydro-l,3-thiazol-5- ylidene]methyl}-5-fluorophenyl 4-(piperidin-l-yl)piperidine-l-carboxylate dihydrochloride; To a solution of 4-piperidinepiperidine (2.O g, 11.9 mmol) in anhydrous CH2Cl2 (50 mL) at 0 0C was added a triphosgene solution (1.3 g, 4.3 mmol) in anhydrous CH2Cl2 (10 mL)by syringe pump addition (1 hour). The mixture was stirred at room temperature overnight. The solid material was removed by filtration. The mixture was extracted with 10% NaHCO3 (2 x 50 mL) and brine (1 x 50 mL). The organic phase was dried over MgSO4, filtered, evaporated, and dried in vacuo, affording the 4-piperidinopiperidinecarbonyl chloride (1.6 g, 59%). The product was used without further purification.To a mixture of (5Z)-2-(l,2-diazinan-l-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]- 4,5-dihydro-l,3-thiazol-4-one (1.0 g, 3.3 mmol) in anhydrous acetonitrile (15 mL) was added potassium carbonate (900 mg, 6.6 mmol), followed by a solution of 4- piperidinopiperidinecarbonyl chloride (1.07 g, 4.6 mmol) in anhydrous acetonitrile (5 mL). The reaction mixture was stirred at reflux for 60 hours. After cooling the mixture to room temperature, the solid material was removed by filtration. The filtrate was recovered and evaporated under reduced pressure. The crude product was purified by flash chromatography (Combiflash Rf, 0-20% MeOH/CH2Cl2). The residue was triturated with diethyl ether (50 mL x 2). The solid material was recovered by filtration and dried in vacuo, affording 2-{[(5E)-2-(l,2- diazinan-l-yl)-4-oxo-4,5-dihydro-l,3-thiazol-5-ylidene]methyl}-5-fluorophenyl 4-(piperidin-l- yl)piperidine-l-carboxylate (954 mg, 57%).To a mixture of 2-{[(5E)-2-(l,2-diazinan-l-yl)-4-oxo-4,5-dihydro-l,3-thiazol-5- ylidene]methyl}-5-fluorophenyl 4-(piperidin-l-yl)piperidine-l-carboxylate (954 mg, 1.9 mmol) in methanol (5 mL) was added a solution of 4M HCl/ dioxane (3 mL, 12.0 mmol). The resultant solution was filtered, and the filtrate was recovered and evaporated. The solid was triturated with diethyl ether (50 mL). The solid material was recovered by filtration and dried in vacuo, affording the final compound (931mg, 91%). 1H NMR (400 MHz, DMSO-J6) 1-45 (m, IH), 1.81 (m, HH), 2.16 (m, 2H), 2.96 (m, 5H), 3.15 (m, IH), 3.44 (m, 3H), 3.88 (m, 2H), 4.11 (m, IH), 4.35 (m,lH) 6.17 (t, IH, J= 6.7 Hz), 7.32 (m, 2H), 7.47 (s, IH), 7.67 (t, IH, J= 6.3 Hz); M+ 502. HPLC purity: 99.1%.

The synthetic route of 4897-50-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHLORION PHARMA, INC.; WO2009/97695; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4897-50-1, 4-Piperidinopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyi 4-(6-ami -3-pyridyl)piperazine-l-carboxylate (0500) The compound was prepared as described in WO 2010/020675 Al . (0501) (0502) To 5-bromo-2-nitropyridine (1.2 g, 5.9 mmole) in DMSO (4 mL) was added l -(4- piperidyl)piperidine (1.0 g, 5.9 mmole) and triethylamine (0.99 mL, 7.1 mmole). The contents were heated to 120 C in a CEM Discovery microwave system for 3 hours. The crude reaction was then loaded over a silica gel column and eluted with DCM/methanol (0-20%) to afford 2- nitro-5-[4-(l-piperidyl)-l -piperidyl]pyridine as an oil (457 mg). NMR (600 MHz, DMSO-c e) delta ppm 1.26 – 1.36 (m, 2 H) 1.43 (m, 6 H) 1.76 (m, 2 H) 2.37 (m, 5 H) 2.94 (t, J=12.74 Hz, 2 H) 4.06 (d, J=13.47 Hz, 2 H) 7.41 (dd, J=9.37, 2.64 Hz, 1 H) 8.08 (d, J=9.37 Hz, 1 H) 8.20 (d, J=2.64 Hz, 1 H)

4897-50-1, The synthetic route of 4897-50-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; G1 THERAPEUTICS, INC.; STRUM, Jay, Copelnad; (156 pag.)WO2018/5863; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4897-50-1, 4-Piperidinopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-tert-butoxycarbonylamino-4-oxo-4- [4- (2-oxo-1, 4- dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butyric acid (1.14 g, 2.55 mmol) and 4- [PIPERIDINYL-PIPERIDINE] (525 mg, 2.81 mmol) in methylene chloride (20 [ML)] was added [3- (DIETHOXYPHOSPHORYLOXY)-1,] 2,3-benzotriain-4 [(3H)-ONE] (DEPBT, 840 mg, 2.81 mmol) in one portion followed by dropwise addition of triethylamine (0.427 [ML,] 3.06 mmol). The resulted mixture was stirred at room temperature overnight (15 h). The mixture was diluted with methylene chloride and washed with sodium hydroxide (0.5 N) solution and water. The layers were separated and the organic layer was dried with sodium sulfate and concentrated [IN VACUO] to give a light yellow foam. The crude product was purified by flash column chromatography (10percent [(1M] ammonia in methanol) in methylene chloride) to give a colorless foam (1.08 g, [71percent).] [APOS;H-NMR] (400 MHz, [CDC13)] [8] 8.86-8. 55 [(1H,] br), 7.05 [(1H,] br), 6.93 [(1H,] br), 6.82 [(1H,] br), 6.72 [(1H,] d, J = 7.6 Hz), 6.10-5. 68 [(1H,] br), 5.20 [(1H,] m), 54.70-4. 40 (2H, br), 4.20 (2H, br), 4. [01-3. 82] (2H, br. ), 3.10-2. 88 (3H, br), 2.99 (3H, br), 2.53 (6H, br), 1.90-1. 10 (23H, m). Mass spec.: 597 [(MH) +.]

4897-50-1, 4897-50-1 4-Piperidinopiperidine 78607, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/104236; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4897-50-1, 4-Piperidinopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-tert-butoxycarbonylamino-4-oxo-4- [4- (2-oxo-1, 4- dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butyric acid (1.14 g, 2.55 mmol) and 4- [PIPERIDINYL-PIPERIDINE] (525 mg, 2.81 mmol) in methylene chloride (20 [ML)] was added [3- (DIETHOXYPHOSPHORYLOXY)-1,] 2,3-benzotriain-4 [(3H)-ONE] (DEPBT, 840 mg, 2.81 mmol) in one portion followed by dropwise addition of triethylamine (0.427 [ML,] 3.06 mmol). The resulted mixture was stirred at room temperature overnight (15 h). The mixture was diluted with methylene chloride and washed with sodium hydroxide (0.5 N) solution and water. The layers were separated and the organic layer was dried with sodium sulfate and concentrated [IN VACUO] to give a light yellow foam. The crude product was purified by flash column chromatography (10percent [(1M] ammonia in methanol) in methylene chloride) to give a colorless foam (1.08 g, [71percent).] [APOS;H-NMR] (400 MHz, [CDC13)] [8] 8.86-8. 55 [(1H,] br), 7.05 [(1H,] br), 6.93 [(1H,] br), 6.82 [(1H,] br), 6.72 [(1H,] d, J = 7.6 Hz), 6.10-5. 68 [(1H,] br), 5.20 [(1H,] m), 54.70-4. 40 (2H, br), 4.20 (2H, br), 4. [01-3. 82] (2H, br. ), 3.10-2. 88 (3H, br), 2.99 (3H, br), 2.53 (6H, br), 1.90-1. 10 (23H, m). Mass spec.: 597 [(MH) +.]

4897-50-1, 4897-50-1 4-Piperidinopiperidine 78607, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/104236; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4897-50-1, 4-Piperidinopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 3 PREPARATION OF 4-PIPERIDINOPIPERIDINE CARBAMOYL CHLORIDE 150 g of 4-piperidinopiperidine was dissolved in 10.5 L of dichloromethane and the solution was cooled to about 0¡ã C. A solution of triphosgene (94.8 g of triphosgene in 1.2 L of dichloromethane) was added slowly to the solution at about 5¡ã C. over a period of 45 minutes under a nitrogen atmosphere with simultaneous stirring. The resultant reaction mixture was stirred at 27¡ã C. for 12 hours. The reaction mixture was filtered and then the filtrate was washed with 1.2 L of 7percent sodium bicarbonate solution. The organic layer was separated and concentrated completely at about 40¡ã C. under a vacuum of 580 mm Hg to afford title compound. Purity: 97.2percent by GC.

4897-50-1, 4897-50-1 4-Piperidinopiperidine 78607, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Palle, Venkata Raghavendra Acharyulu; Nariyam, Sekhar Munaswamy; Matti, Lankeshwararao; Vinjamuri, Raghupati Rama Subrahmanyam; US2007/208050; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4897-50-1,4-Piperidinopiperidine,as a common compound, the synthetic route is as follows.

Example 61; 7-(l,4′-bipiperidin-r-ylV5-chloro-l-(2,6-difluorophenylV3,4-dihvdropyrimido[4.5- ^pyrimidin-2(‘l.H)-one )To a solution of 5-chloro- 1 -(2,6-difluorophenyl)-7-(methylsulfinyl)-3 ,A- dihydropyrimido[4,5-d]pvrimidin-2(lH)-one (200 mg, 0.56 mmol) in DCM (10 mL) were added 1 ,4’-bipiperidine (270 mg, 1.61 mmol) and AzetaN-diisopropylethylamine (0.3 mL, 1.7 mmol). The resultant solution was stirred at room temperature over night. The result mixture was concentrated. CombiFlash chromatography (mobile phase DCM/DCM[90]+MeOH[7]+NuH4OH[3]) provided the title compound as a white solid (298 mg, 83 percent). LC-MS m/z 463 (M + H)+.

4897-50-1, As the paragraph descriping shows that 4897-50-1 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/104917; (2006); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4897-50-1,4897-50-1, 4-Piperidinopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of triphosgene (8 g, 26.9 mmol) in dry dichloromethane (40 mL) at -7 C were added dry triethylamine (1 mL, 7.1 mmol) and dropwise a solution of 1,4′-dipiperidine (5 g, 29.7 mmol) in dry dichloromethane (35 mL) over a period of 50 min. Then the solution was stirred at room temperature for 8 h, at which time the reaction was completed, the solution was filtered, the filtrate was concentrated, the residue was reacted with 23-hydroxybetulinic acid directly without further purification.

As the paragraph descriping shows that 4897-50-1 is playing an increasingly important role.

Reference£º
Article; Lan, Ping; Wang, Jiao; Zhang, Dong-Mei; Shu, Chang; Cao, Hui-Hui; Sun, Ping-Hua; Wu, Xiao-Ming; Ye, Wen-Cai; Chen, Wei-Min; European Journal of Medicinal Chemistry; vol. 46; 6; (2011); p. 2490 – 2502;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem